ID   ECTA_MARHA              Reviewed;         172 AA.
AC   O06059;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=L-2,4-diaminobutyric acid acetyltransferase;
DE            Short=DABA acetyltransferase;
DE            EC=2.3.1.178;
GN   Name=ectA;
OS   Marinococcus halophilus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Marinococcus.
OX   NCBI_TaxID=1371;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=ATCC 27964 / DSM 20408 / CIP 140819 / JCM 2479 / NBRC 102359 / NCIMB
RC   13496 / CCM 2706;
RX   PubMed=9141677; DOI=10.1099/00221287-143-4-1141;
RA   Louis P., Galinski E.A.;
RT   "Characterization of genes for the biosynthesis of the compatible solute
RT   ectoine from Marinococcus halophilus and osmoregulated expression in
RT   Escherichia coli.";
RL   Microbiology 143:1141-1149(1997).
CC   -!- FUNCTION: Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to
CC       gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl
CC       coenzyme A. {ECO:0000269|PubMed:9141677}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + L-2,4-diaminobutanoate = (2S)-4-acetamido-2-
CC         aminobutanoate + CoA + H(+); Xref=Rhea:RHEA:16901, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:58761,
CC         ChEBI:CHEBI:58929; EC=2.3.1.178;
CC   -!- PATHWAY: Amine and polyamine biosynthesis; ectoine biosynthesis; L-
CC       ectoine from L-aspartate 4-semialdehyde: step 2/3.
CC   -!- SIMILARITY: Belongs to the acetyltransferase family. EctA subfamily.
CC       {ECO:0000305}.
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DR   EMBL; U66614; AAB57633.1; -; Genomic_DNA.
DR   AlphaFoldDB; O06059; -.
DR   SMR; O06059; -.
DR   STRING; 1371.GCA_900166605_00961; -.
DR   KEGG; ag:AAB57633; -.
DR   UniPathway; UPA00067; UER00122.
DR   GO; GO:0033816; F:diaminobutyrate acetyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008080; F:N-acetyltransferase activity; IEA:InterPro.
DR   GO; GO:0019491; P:ectoine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR012772; Ectoine_EctA.
DR   InterPro; IPR000182; GNAT_dom.
DR   Pfam; PF00583; Acetyltransf_1; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   TIGRFAMs; TIGR02406; ectoine_EctA; 1.
DR   PROSITE; PS51186; GNAT; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Transferase.
FT   CHAIN           1..172
FT                   /note="L-2,4-diaminobutyric acid acetyltransferase"
FT                   /id="PRO_0000220087"
FT   DOMAIN          15..166
FT                   /note="N-acetyltransferase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00532"
SQ   SEQUENCE   172 AA;  19386 MW;  0E87A586342276C8 CRC64;
     METKMTGTNG SVDSIVFDKP TVEDGADMWE LVKNSTLDLN SSYKYIMMCE FFAETCVVAK
     ENDELVGFVT AFIPPEKQDT VFVWQVGVDT SQRGKGLASR LLNALLERDV CENVLYLEAT
     ITPSNEASQA LFKKLAQKRE TEVTVSECFT EDLFPDDEHE EELTFRIGPF TK