ECTA_NOCFA
ID ECTA_NOCFA Reviewed; 193 AA.
AC Q5YW78;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=L-2,4-diaminobutyric acid acetyltransferase;
DE Short=DABA acetyltransferase;
DE EC=2.3.1.178;
GN Name=ectA; OrderedLocusNames=NFA_27160;
OS Nocardia farcinica (strain IFM 10152).
OC Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Nocardia.
OX NCBI_TaxID=247156;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IFM 10152;
RX PubMed=15466710; DOI=10.1073/pnas.0406410101;
RA Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K.,
RA Shiba T., Hattori M.;
RT "The complete genomic sequence of Nocardia farcinica IFM 10152.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004).
CC -!- FUNCTION: Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to
CC gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl
CC coenzyme A. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + L-2,4-diaminobutanoate = (2S)-4-acetamido-2-
CC aminobutanoate + CoA + H(+); Xref=Rhea:RHEA:16901, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:58761,
CC ChEBI:CHEBI:58929; EC=2.3.1.178;
CC -!- PATHWAY: Amine and polyamine biosynthesis; ectoine biosynthesis; L-
CC ectoine from L-aspartate 4-semialdehyde: step 2/3.
CC -!- SIMILARITY: Belongs to the acetyltransferase family. EctA subfamily.
CC {ECO:0000305}.
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DR EMBL; AP006618; BAD57563.1; -; Genomic_DNA.
DR AlphaFoldDB; Q5YW78; -.
DR SMR; Q5YW78; -.
DR STRING; 247156.NFA_27160; -.
DR EnsemblBacteria; BAD57563; BAD57563; NFA_27160.
DR KEGG; nfa:NFA_27160; -.
DR eggNOG; COG0456; Bacteria.
DR HOGENOM; CLU_111896_0_0_11; -.
DR OMA; DGAAIWR; -.
DR UniPathway; UPA00067; UER00122.
DR Proteomes; UP000006820; Chromosome.
DR GO; GO:0033816; F:diaminobutyrate acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008080; F:N-acetyltransferase activity; IEA:InterPro.
DR GO; GO:0019491; P:ectoine biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR012772; Ectoine_EctA.
DR InterPro; IPR000182; GNAT_dom.
DR Pfam; PF00583; Acetyltransf_1; 1.
DR SUPFAM; SSF55729; SSF55729; 1.
DR TIGRFAMs; TIGR02406; ectoine_EctA; 1.
DR PROSITE; PS51186; GNAT; 1.
PE 3: Inferred from homology;
KW Acyltransferase; Reference proteome; Transferase.
FT CHAIN 1..193
FT /note="L-2,4-diaminobutyric acid acetyltransferase"
FT /id="PRO_0000220088"
FT DOMAIN 33..185
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00532"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 193 AA; 21062 MW; C162015FF0A0DBC1 CRC64;
MSLQTLSTPT AEPVEEPRPV EAPWQVSDRI GTALLRAPQL GDAAEIWRIA KDSRVLDTNS
SYAYLLWCRD FPGTTVVAEV DGRAVGFVIG YLRPESPDTV FVWQVAVSPT ERGRGTGTAL
IQKLLDRVAP HGVTALETTI SPDNPASIAM FAAVARRRGA QLTKQPLFDA GVFPDEHAPE
DLYRIAPIAQ EIR