ID   ECTC_STRAQ              Reviewed;         132 AA.
AC   Q6QUY8;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=L-ectoine synthase;
DE            EC=4.2.1.108;
DE   AltName: Full=N-acetyldiaminobutyrate dehydratase;
GN   Name=ectC; Synonyms=thpC;
OS   Streptomyces anulatus (Streptomyces chrysomallus).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1892;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 11523 / DSM 40128 / JCM 4296 / LMG 20459 / NBRC 15393;
RX   PubMed=15128576; DOI=10.1128/aem.70.5.3130-3132.2004;
RA   Prabhu J., Schauwecker F., Grammel N., Keller U., Bernhard M.;
RT   "Functional expression of the ectoine hydroxylase gene (thpD) from
RT   Streptomyces chrysomallus in Halomonas elongata.";
RL   Appl. Environ. Microbiol. 70:3130-3132(2004).
CC   -!- FUNCTION: Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-
CC       diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-
CC       pyrimidine carboxylic acid), which is an excellent osmoprotectant.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2S)-4-acetamido-2-aminobutanoate = H2O + L-ectoine;
CC         Xref=Rhea:RHEA:17281, ChEBI:CHEBI:15377, ChEBI:CHEBI:58515,
CC         ChEBI:CHEBI:58929; EC=4.2.1.108;
CC   -!- PATHWAY: Amine and polyamine biosynthesis; ectoine biosynthesis; L-
CC       ectoine from L-aspartate 4-semialdehyde: step 3/3.
CC   -!- SIMILARITY: Belongs to the ectoine synthase family. {ECO:0000305}.
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DR   EMBL; AY524544; AAS02096.1; -; Genomic_DNA.
DR   RefSeq; WP_007450483.1; NZ_CM003601.1.
DR   AlphaFoldDB; Q6QUY8; -.
DR   SMR; Q6QUY8; -.
DR   GeneID; 63979127; -.
DR   UniPathway; UPA00067; UER00123.
DR   GO; GO:0033990; F:ectoine synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019491; P:ectoine biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd06978; cupin_EctC; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   HAMAP; MF_01255; Ectoine_synth; 1.
DR   InterPro; IPR010462; Ectoine_synth.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   PANTHER; PTHR39289; PTHR39289; 1.
DR   Pfam; PF06339; Ectoine_synth; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
PE   3: Inferred from homology;
KW   Lyase.
FT   CHAIN           1..132
FT                   /note="L-ectoine synthase"
FT                   /id="PRO_0000220157"
SQ   SEQUENCE   132 AA;  14971 MW;  D35250A26C1947CD CRC64;
     MIVRSFSDIE NTDRHVKAAS GTWESKRIVL AKEKVGFSLH ETVLYAGTET SMWYANHIEA
     VLCTEGEAEL TNDETGETHW ITPGTMYLLD GHERHTMRPK TDFRCVCVFN PPVTGREDHD
     ENGVYPLLTE EA