ECTC_VIBCH
ID ECTC_VIBCH Reviewed; 138 AA.
AC Q9KLC3;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=L-ectoine synthase {ECO:0000255|HAMAP-Rule:MF_01255};
DE EC=4.2.1.108 {ECO:0000255|HAMAP-Rule:MF_01255};
DE AltName: Full=N-acetyldiaminobutyrate dehydratase {ECO:0000255|HAMAP-Rule:MF_01255};
GN Name=ectC {ECO:0000255|HAMAP-Rule:MF_01255}; OrderedLocusNames=VC_A0823;
OS Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=243277;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX PubMed=10952301; DOI=10.1038/35020000;
RA Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT cholerae.";
RL Nature 406:477-483(2000).
CC -!- FUNCTION: Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-
CC diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-
CC pyrimidine carboxylic acid), which is an excellent osmoprotectant.
CC {ECO:0000255|HAMAP-Rule:MF_01255}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2S)-4-acetamido-2-aminobutanoate = H2O + L-ectoine;
CC Xref=Rhea:RHEA:17281, ChEBI:CHEBI:15377, ChEBI:CHEBI:58515,
CC ChEBI:CHEBI:58929; EC=4.2.1.108; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01255};
CC -!- PATHWAY: Amine and polyamine biosynthesis; ectoine biosynthesis; L-
CC ectoine from L-aspartate 4-semialdehyde: step 3/3. {ECO:0000255|HAMAP-
CC Rule:MF_01255}.
CC -!- SIMILARITY: Belongs to the ectoine synthase family. {ECO:0000255|HAMAP-
CC Rule:MF_01255}.
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DR EMBL; AE003853; AAF96721.1; -; Genomic_DNA.
DR PIR; G82412; G82412.
DR RefSeq; NP_233209.1; NC_002506.1.
DR RefSeq; WP_000637098.1; NZ_LT906615.1.
DR AlphaFoldDB; Q9KLC3; -.
DR SMR; Q9KLC3; -.
DR STRING; 243277.VC_A0823; -.
DR DNASU; 2612354; -.
DR EnsemblBacteria; AAF96721; AAF96721; VC_A0823.
DR GeneID; 57742201; -.
DR KEGG; vch:VC_A0823; -.
DR PATRIC; fig|243277.26.peg.3443; -.
DR eggNOG; COG0662; Bacteria.
DR HOGENOM; CLU_154525_0_0_6; -.
DR OMA; CVFNPPI; -.
DR BioCyc; VCHO:VCA0823-MON; -.
DR UniPathway; UPA00067; UER00123.
DR Proteomes; UP000000584; Chromosome 2.
DR GO; GO:0033990; F:ectoine synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0019491; P:ectoine biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd06978; cupin_EctC; 1.
DR Gene3D; 2.60.120.10; -; 1.
DR HAMAP; MF_01255; Ectoine_synth; 1.
DR InterPro; IPR010462; Ectoine_synth.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR PANTHER; PTHR39289; PTHR39289; 1.
DR Pfam; PF06339; Ectoine_synth; 1.
DR SUPFAM; SSF51182; SSF51182; 1.
PE 3: Inferred from homology;
KW Lyase; Reference proteome.
FT CHAIN 1..138
FT /note="L-ectoine synthase"
FT /id="PRO_0000220159"
SQ SEQUENCE 138 AA; 15996 MW; 500962E3FEBF8F05 CRC64;
MIVRTLEECR QSERRVVAEN WESVRMLLKD DHMGFSFHIT TIYANTQTHI HYRNHLESVY
CMSGEGEIEV VGGKTYPIQP GTLYILDQHD EHYLRAFSSE MVMACVFNPP LTGHEIHDAE
GVYPLDKSEL ISQCHKEK