ID   ADRB3_MERUN             Reviewed;         167 AA.
AC   O70432;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Beta-3 adrenergic receptor;
DE   AltName: Full=Beta-3 adrenoreceptor;
DE            Short=Beta-3 adrenoceptor;
DE   Flags: Fragment;
GN   Name=ADRB3;
OS   Meriones unguiculatus (Mongolian jird) (Gerbillus unguiculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Gerbillinae; Meriones.
OX   NCBI_TaxID=10047;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Adipose tissue, Brain, and Stria vascularis;
RX   PubMed=10398761; DOI=10.1007/s002329900538;
RA   Wangemann P., Liu J., Shimozono M., Scofield M.A.;
RT   "Beta1-adrenergic receptors but not beta2-adrenergic or vasopressin
RT   receptors regulate K+ secretion in vestibular dark cells of the inner
RT   ear.";
RL   J. Membr. Biol. 170:67-77(1999).
CC   -!- FUNCTION: Beta-adrenergic receptors mediate the catecholamine-induced
CC       activation of adenylate cyclase through the action of G proteins. Beta-
CC       3 is involved in the regulation of lipolysis and thermogenesis.
CC   -!- SUBUNIT: Interacts with ARRDC3. {ECO:0000250|UniProtKB:P13945}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Adrenergic receptor subfamily. ADRB3 sub-subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF055351; AAC12769.1; -; mRNA.
DR   AlphaFoldDB; O70432; -.
DR   SMR; O70432; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004939; F:beta-adrenergic receptor activity; IEA:InterPro.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   InterPro; IPR000681; ADRB3_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00563; ADRENRGCB3AR.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW   Receptor; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           <1..>167
FT                   /note="Beta-3 adrenergic receptor"
FT                   /id="PRO_0000069145"
FT   TOPO_DOM        <1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        26..47
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        48..114
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        115..136
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        137..148
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        149..>167
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000250"
FT   REGION          66..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        11..17
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   NON_TER         1
FT   NON_TER         167
SQ   SEQUENCE   167 AA;  18324 MW;  CEA78CF68DEEE1C1 CRC64;
     RVGADAEAQE CHSNPRCCSF ASNMPYALLS SSVSFYLPLL VMLFVYARVF VVAKRQRRLL
     RRELGRFPPE ESPRSPSRSP SPVAGGTGEA PDGVPSCGRR PARLLPLREH RALRTLGLIM
     GIFSLCWLPF FLANVLRALA GPSIVPNGVF IALNWLGYAN SAFNPLI