ID   EDAD_MACFA              Reviewed;         206 AA.
AC   Q95LN5;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Ectodysplasin-A receptor-associated adapter protein;
GN   Name=EDARADD; ORFNames=QtsA-18001;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA   Terao K., Sugano S., Hashimoto K.;
RT   "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT   the human genome sequence.";
RL   BMC Genomics 3:36-36(2002).
CC   -!- FUNCTION: Adapter protein that interacts with EDAR DEATH domain and
CC       couples the receptor to EDA signaling pathway during morphogenesis of
CC       ectodermal organs. Mediates the activation of NF-kappa-B (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Self-associates and binds to EDAR, TRAF1, TRAF2 and TRAF3.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
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DR   EMBL; AB072753; BAB69722.1; -; mRNA.
DR   RefSeq; NP_001270064.1; NM_001283135.1.
DR   AlphaFoldDB; Q95LN5; -.
DR   SMR; Q95LN5; -.
DR   STRING; 9541.XP_005539775.1; -.
DR   GeneID; 102139401; -.
DR   CTD; 128178; -.
DR   eggNOG; KOG4602; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.533.10; -; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR039200; EDARADD.
DR   PANTHER; PTHR28469; PTHR28469; 1.
DR   Pfam; PF00531; Death; 1.
DR   SUPFAM; SSF47986; SSF47986; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Differentiation; Reference proteome.
FT   CHAIN           1..206
FT                   /note="Ectodysplasin-A receptor-associated adapter protein"
FT                   /id="PRO_0000086929"
FT   DOMAIN          114..190
FT                   /note="Death"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          52..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..36
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..70
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   206 AA;  23855 MW;  F917255202B6706D CRC64;
     MRPLQSYKAF EDHMAQEPVE DTDPSTLSFN TSDKYPVQDT ELPKAEECNT ITLNCPPNSD
     MKNQGEENGF PDSTGDPLPE ISKDNSCKEN CTCSSCLLRA PTISDLLNDQ DLLDVIRIKL
     DPCHPTVKNW RNFASKWGMS YDELCFLEQR PQSPTLEFLL RNSQRTVGQL MELCRLYHRA
     DVEKVLRRWV DEEWPKRERG DPSRHF