ID   EDAD_MOUSE              Reviewed;         208 AA.
AC   Q8VHX2;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Ectodysplasin-A receptor-associated adapter protein;
DE   AltName: Full=EDAR-associated death domain protein;
DE   AltName: Full=Protein crinkled;
GN   Name=Edaradd; Synonyms=Cr;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND MUTAGENESIS OF GLU-145.
RC   STRAIN=FVB/N; TISSUE=Skin;
RX   PubMed=11780064; DOI=10.1038/414913a;
RA   Headon D.J., Emmal S.A., Ferguson B.M., Tucker A.S., Justice M.J.,
RA   Sharpe P.T., Zonana J., Overbeek P.A.;
RT   "Gene defect in ectodermal dysplasia implicates a DEATH domain adapter in
RT   development.";
RL   Nature 414:913-916(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   TISSUE=Skin;
RX   PubMed=11882293; DOI=10.1016/s0960-9822(02)00687-5;
RA   Yan M., Zhang Z., Brady J.R., Schilbach S., Fairbrother W.J., Dixit V.M.;
RT   "Identification of a novel DEATH domain-containing adaptor molecule for
RT   ectodysplasin-A receptor that is mutated in crinkled mice.";
RL   Curr. Biol. 12:409-413(2002).
CC   -!- FUNCTION: Adapter protein that interacts with EDAR DEATH domain and
CC       couples the receptor to EDA signaling pathway during morphogenesis of
CC       ectodermal organs. Mediates the activation of NF-kappa-B (By
CC       similarity). {ECO:0000250, ECO:0000269|PubMed:11882293}.
CC   -!- SUBUNIT: Binds EDAR. Self-associates and binds TRAF1, TRAF2 and TRAF3
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Detected in embryonic skin (12.5 dpc and 14.5 dpc)
CC       during the formation of hair follicles and at 15.5 dpc in the enamel
CC       knot of the developing tooth. Detected in the basal layer of the
CC       epidermis and hair follicles of P2 mice.
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DR   EMBL; AF358671; AAL50376.1; -; mRNA.
DR   CCDS; CCDS36593.1; -.
DR   AlphaFoldDB; Q8VHX2; -.
DR   SMR; Q8VHX2; -.
DR   STRING; 10090.ENSMUSP00000136158; -.
DR   PhosphoSitePlus; Q8VHX2; -.
DR   EPD; Q8VHX2; -.
DR   MaxQB; Q8VHX2; -.
DR   PaxDb; Q8VHX2; -.
DR   PRIDE; Q8VHX2; -.
DR   MGI; MGI:1931001; Edaradd.
DR   eggNOG; KOG4602; Eukaryota.
DR   InParanoid; Q8VHX2; -.
DR   PhylomeDB; Q8VHX2; -.
DR   Reactome; R-MMU-5669034; TNFs bind their physiological receptors.
DR   ChiTaRS; Edaradd; mouse.
DR   PRO; PR:Q8VHX2; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q8VHX2; protein.
DR   GO; GO:0005737; C:cytoplasm; NAS:UniProtKB.
DR   GO; GO:0005123; F:death receptor binding; NAS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0001942; P:hair follicle development; IGI:MGI.
DR   GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; NAS:UniProtKB.
DR   GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IMP:MGI.
DR   GO; GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; ISO:MGI.
DR   GO; GO:0061153; P:trachea gland development; IMP:MGI.
DR   Gene3D; 1.10.533.10; -; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR039200; EDARADD.
DR   PANTHER; PTHR28469; PTHR28469; 1.
DR   Pfam; PF00531; Death; 1.
DR   SUPFAM; SSF47986; SSF47986; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Developmental protein; Differentiation; Reference proteome.
FT   CHAIN           1..208
FT                   /note="Ectodysplasin-A receptor-associated adapter protein"
FT                   /id="PRO_0000086930"
FT   DOMAIN          116..195
FT                   /note="Death"
FT   REGION          1..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..90
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MUTAGEN         145
FT                   /note="E->K: Reduces binding to EDAR."
FT                   /evidence="ECO:0000269|PubMed:11780064"
FT   CONFLICT        89
FT                   /note="R -> G (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   208 AA;  23753 MW;  C5BFA0F91E5D5BC9 CRC64;
     MASPDDPLRS DHMAKEPVED TDPSTLSFAM SDKYPIQDTG LPKAKECDTV NSNCPPNSDD
     QPQGEENDFP DSTKDPLSGV SRNQPCKDRK GSCSCPSCSP RAPTISDLLN DQDLLDTIRI
     KLDPCHPTVK NWRNFASKWG MPYDELCFLE QRPQSPTLEF LFRNSQRTVG QLMELCRLYH
     RADVEKILRR WVDEEWPHRG HSDSSMHF