ID   EDC1_PICST              Reviewed;         339 AA.
AC   A3LTE2;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Enhancer of mRNA-decapping protein 1;
GN   Name=EDC1; ORFNames=PICST_67536;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: mRNA-binding protein which stimulates mRNA decapping.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EDC family. {ECO:0000305}.
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DR   EMBL; CP000498; ABN66387.1; -; Genomic_DNA.
DR   RefSeq; XP_001384416.1; XM_001384379.1.
DR   AlphaFoldDB; A3LTE2; -.
DR   EnsemblFungi; ABN66387; ABN66387; PICST_67536.
DR   GeneID; 4838990; -.
DR   KEGG; pic:PICST_67536; -.
DR   eggNOG; ENOG502RIVV; Eukaryota.
DR   HOGENOM; CLU_860511_0_0_1; -.
DR   InParanoid; A3LTE2; -.
DR   OMA; GYINYQY; -.
DR   OrthoDB; 1632916at2759; -.
DR   Proteomes; UP000002258; Chromosome 4.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cytoplasm; mRNA processing; Nonsense-mediated mRNA decay;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..339
FT                   /note="Enhancer of mRNA-decapping protein 1"
FT                   /id="PRO_0000285360"
FT   REGION          1..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          309..339
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..40
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..73
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        109..131
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..172
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        178..227
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   339 AA;  36686 MW;  C197D442190128EC CRC64;
     MMMHELPVPI HQSPGSENHS NPASREQSKP KKETERRLPS GAKVDFGNGS GSKKQQSNQK
     PKKGSDSEKK KANRANSPAL PNGEKPNFYN DNKEKNKKLL DPSLPNGAKP NFSFYSESNS
     NSNSNVSSNS NKTKKKVHEQ SLPSGEKPVF HDKPNKKTSS SNRPDKNGKK GPVEETYAGS
     SFHSSPAALN LPKPSFQRTS PKQQANTIND ENSSPSSSAS SVSMSSPRPV AGAVAAPPRY
     PVTAYPPGSI PGAVPNVPAG YYPPQYAQPQ YIQPGFTYNV NPQGYIQYQY PPFHHPLAPA
     QIPYQQHPFP VNAQPPAHVG SAPQGQKISF DDLLGSAKK