ID   EDC3_CHICK              Reviewed;         506 AA.
AC   Q5ZLS2;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Enhancer of mRNA-decapping protein 3;
DE   AltName: Full=YjeF domain-containing protein 1;
GN   Name=EDC3; Synonyms=YJDC; ORFNames=RCJMB04_5b1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Binds single-stranded RNA. Involved in the process of mRNA
CC       degradation and in the positive regulation of mRNA decapping (By
CC       similarity). {ECO:0000250|UniProtKB:Q96F86}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000250}. Note=Processing
CC       bodies (PB). {ECO:0000250}.
CC   -!- DOMAIN: The DFDF domain is unstructured by itself. It assumes a helical
CC       fold upon interaction with other proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EDC3 family. {ECO:0000305}.
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DR   EMBL; AJ719662; CAG31321.1; -; mRNA.
DR   RefSeq; NP_001025556.1; NM_001030385.1.
DR   AlphaFoldDB; Q5ZLS2; -.
DR   SMR; Q5ZLS2; -.
DR   STRING; 9031.ENSGALP00000002041; -.
DR   PaxDb; Q5ZLS2; -.
DR   GeneID; 415294; -.
DR   KEGG; gga:415294; -.
DR   CTD; 80153; -.
DR   VEuPathDB; HostDB:geneid_415294; -.
DR   eggNOG; KOG2585; Eukaryota.
DR   InParanoid; Q5ZLS2; -.
DR   OrthoDB; 870769at2759; -.
DR   PhylomeDB; Q5ZLS2; -.
DR   PRO; PR:Q5ZLS2; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0000932; C:P-body; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0031087; P:deadenylation-independent decapping of nuclear-transcribed mRNA; IBA:GO_Central.
DR   GO; GO:0033962; P:P-body assembly; IBA:GO_Central.
DR   CDD; cd01737; LSm16_N; 1.
DR   Gene3D; 3.40.50.10260; -; 1.
DR   InterPro; IPR025762; DFDF.
DR   InterPro; IPR019050; FDF_dom.
DR   InterPro; IPR025609; Lsm14-like_N.
DR   InterPro; IPR034107; Lsm16_N.
DR   InterPro; IPR004443; YjeF_N_dom.
DR   InterPro; IPR036652; YjeF_N_dom_sf.
DR   Pfam; PF09532; FDF; 1.
DR   Pfam; PF12701; LSM14; 1.
DR   Pfam; PF03853; YjeF_N; 1.
DR   SMART; SM01199; FDF; 1.
DR   SMART; SM01271; LSM14; 1.
DR   SUPFAM; SSF64153; SSF64153; 1.
DR   PROSITE; PS51512; DFDF; 1.
DR   PROSITE; PS51385; YJEF_N; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; RNA-binding.
FT   CHAIN           1..506
FT                   /note="Enhancer of mRNA-decapping protein 3"
FT                   /id="PRO_0000119058"
FT   DOMAIN          190..226
FT                   /note="DFDF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00845"
FT   DOMAIN          281..485
FT                   /note="YjeF N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00719"
FT   REGION          1..79
FT                   /note="Required for P-body targeting and interaction with
FT                   DCP1A"
FT                   /evidence="ECO:0000250"
FT   REGION          99..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          149..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          189..294
FT                   /note="Required for interaction with DDX6"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        153..178
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   506 AA;  56037 MW;  5A4566FACC512158 CRC64;
     MATDWLGSIV SINCGESLGV YQGRVSAVDQ VSQTISLTRP FHNGVKCLVP EVTFRAGDIT
     ELKILEIPGP GDSRQCGDLQ QADTGIPGVG CQVGPSQNGT GKMLKKPFSS SAPQNIPRRT
     DMKNQDIIIS PQQQCSKSYM DRHMETLSQS KGFRRRHNSW SSSSRHPNQV TPKKSGLKNG
     QMKSKDDECF GDDIDEIPDT DFDFEGNLAL FDKAAVFEEI ETYERRSGTR SRGTPNEKPA
     RYRHDENILE SEPIVYRRIV VPQNANKEFC TDSGLVVPSV SYELHKKLLS VAEKHGLTLE
     RRLEMTGVCA SQMALSLLGG PNRLNPKNVH QRPTVALLCG PHVKGAQGIS CGRHLSNHDV
     HVILFLPNFV KMLESITNEL NLFSSTQGQQ VSSVKDLPDT PVDLVINCLD CHENAFLRDQ
     PWYKAVVDWA NQNRAPVLSI DPPISEMEQG IDAKWSLALG LPLPLGERAG RVYLCDIGIP
     QKVFQEVGIN YHSPFGCKFV IPLHST