ID   EDC3_XENLA              Reviewed;         505 AA.
AC   Q5XH48;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Enhancer of mRNA-decapping protein 3;
DE   AltName: Full=YjeF domain-containing protein 1;
GN   Name=edc3; Synonyms=yjdc;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds single-stranded RNA. Involved in the process of mRNA
CC       degradation and in the positive regulation of mRNA decapping (By
CC       similarity). {ECO:0000250|UniProtKB:Q96F86}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000250}. Note=Processing
CC       bodies (PB). {ECO:0000250}.
CC   -!- DOMAIN: The DFDF domain is unstructured by itself. It assumes a helical
CC       fold upon interaction with other proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EDC3 family. {ECO:0000305}.
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DR   EMBL; BC084225; AAH84225.1; -; mRNA.
DR   RefSeq; NP_001088234.1; NM_001094765.1.
DR   AlphaFoldDB; Q5XH48; -.
DR   SMR; Q5XH48; -.
DR   BioGRID; 105145; 1.
DR   IntAct; Q5XH48; 1.
DR   DNASU; 495065; -.
DR   GeneID; 495065; -.
DR   KEGG; xla:495065; -.
DR   CTD; 495065; -.
DR   Xenbase; XB-GENE-5890837; edc3.S.
DR   OrthoDB; 870769at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 495065; Expressed in ovary and 19 other tissues.
DR   GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR   GO; GO:0003729; F:mRNA binding; IEA:InterPro.
DR   GO; GO:0031087; P:deadenylation-independent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR   CDD; cd01737; LSm16_N; 1.
DR   Gene3D; 3.40.50.10260; -; 1.
DR   InterPro; IPR025762; DFDF.
DR   InterPro; IPR019050; FDF_dom.
DR   InterPro; IPR025609; Lsm14-like_N.
DR   InterPro; IPR034107; Lsm16_N.
DR   InterPro; IPR004443; YjeF_N_dom.
DR   InterPro; IPR036652; YjeF_N_dom_sf.
DR   Pfam; PF09532; FDF; 1.
DR   Pfam; PF12701; LSM14; 1.
DR   Pfam; PF03853; YjeF_N; 1.
DR   SMART; SM01199; FDF; 1.
DR   SMART; SM01271; LSM14; 1.
DR   SUPFAM; SSF64153; SSF64153; 1.
DR   PROSITE; PS51512; DFDF; 1.
DR   PROSITE; PS51385; YJEF_N; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; RNA-binding.
FT   CHAIN           1..505
FT                   /note="Enhancer of mRNA-decapping protein 3"
FT                   /id="PRO_0000119060"
FT   DOMAIN          187..223
FT                   /note="DFDF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00845"
FT   DOMAIN          280..484
FT                   /note="YjeF N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00719"
FT   REGION          1..79
FT                   /note="Required for P-body targeting and interaction with
FT                   DCP1A"
FT                   /evidence="ECO:0000250"
FT   REGION          84..181
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          186..293
FT                   /note="Required for interaction with DDX6"
FT                   /evidence="ECO:0000250"
FT   REGION          219..243
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..141
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        149..175
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   505 AA;  55576 MW;  C8BE6EF9D0F76E56 CRC64;
     MAADWLGSIV SINCGNTLGV YQGCVSAVDR INQTISLSQP FHNGVKCLVP EVTFRAGDIS
     ELKILEIPSE SLKYTSDQLN DHSTGFGYLP TRQQNGTGKQ KQTVAHNSAQ NIPGQEEGKA
     SEPSSTSPQP CSKSFVDRHN EAVNQPKNFR RRHNSLGSSS SRYPNQVTPK KSGTKNGQLK
     ARDDECFGDE LEEIPDTDFD FEGNLALFDK AAVFEEIDTH ERRGGGGTRS RGTPNERPPT
     YRHDENILES EPIVYRKIVV PQSGGQEYCT DSGLVVPSIS YVLHKKLLCV AEKHGLSVER
     RLEMSGVCAS QMALTLLGGP NRLNPKNVHQ RPTVALLCGP HVKGAQGISC GRHLANYDVD
     IILFLPNFVK MLEPVTNELN LFCQTQGKQV SSVKDLPECP VDLVINCLDC NENAFLCDQP
     WYRAAVDWAN HNRAPVLNID PPVGDHVQGI HAKWSLELGL PLALGEQAGR IYLCDIGIPQ
     KVFREVGISY HSPFGCKFVI PLHSM