EDC4_DANRE
ID EDC4_DANRE Reviewed; 1384 AA.
AC Q1LUT1;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Enhancer of mRNA-decapping protein 4;
GN Name=edc4; ORFNames=si:dkey-16n13.6;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- FUNCTION: In the process of mRNA degradation, seems to play a role in
CC mRNA decapping. {ECO:0000250|UniProtKB:Q6P2E9}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000250|UniProtKB:Q6P2E9}.
CC Nucleus {ECO:0000250|UniProtKB:Q6P2E9}.
CC -!- SIMILARITY: Belongs to the WD repeat EDC4 family. {ECO:0000305}.
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DR EMBL; BX927240; CAK05297.1; -; Genomic_DNA.
DR RefSeq; NP_001038550.1; NM_001045085.1.
DR AlphaFoldDB; Q1LUT1; -.
DR STRING; 7955.ENSDARP00000084220; -.
DR PaxDb; Q1LUT1; -.
DR Ensembl; ENSDART00000185550; ENSDARP00000157062; ENSDARG00000114070.
DR GeneID; 565659; -.
DR KEGG; dre:565659; -.
DR CTD; 23644; -.
DR ZFIN; ZDB-GENE-030131-5032; edc4.
DR eggNOG; KOG1916; Eukaryota.
DR InParanoid; Q1LUT1; -.
DR OrthoDB; 1424637at2759; -.
DR PhylomeDB; Q1LUT1; -.
DR Reactome; R-DRE-430039; mRNA decay by 5' to 3' exoribonuclease.
DR PRO; PR:Q1LUT1; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000932; C:P-body; IBA:GO_Central.
DR GO; GO:0031087; P:deadenylation-independent decapping of nuclear-transcribed mRNA; IBA:GO_Central.
DR Gene3D; 1.10.220.100; -; 1.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR045152; EDC4-like.
DR InterPro; IPR044938; EDC4_C.
DR InterPro; IPR032401; EDC4_WD40.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR15598; PTHR15598; 1.
DR Pfam; PF16529; Ge1_WD40; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Nucleus; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..1384
FT /note="Enhancer of mRNA-decapping protein 4"
FT /id="PRO_0000278965"
FT REPEAT 171..211
FT /note="WD 1"
FT REPEAT 227..274
FT /note="WD 2"
FT REPEAT 292..331
FT /note="WD 3"
FT REPEAT 340..390
FT /note="WD 4"
FT REGION 471..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 796..931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 930..1012
FT /evidence="ECO:0000255"
FT COMPBIAS 554..570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..848
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 891..920
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1384 AA; 151849 MW; 51027F9B46C3508F CRC64;
MASSSSMDIE GATQHLRDIL KLDRPGNSAE ASLVESQRKP SFNGELNGVL GSDLMGAAMV
EPTVHNSDKL NGQDTQTICL SGDDGSICVP IRANIVEIVS SRDSSIDSKA RGSNKVKIQP
VAKYDWEHKY YYGNLIAVSN TYLAYAIRGA NNHSMIRVLH LSSTERSLLK GFTGAVTDLA
FAHLDSTLLG CVDEAGNMFI WQLTSHSSKI QDEVIVHIRR PEDTPLNSNR RLIWCPFIPE
DNDESPEDAC QTLALLHEDR AEVWDLDILR SNNSSWPVDA TELKEGFITI RGHAARISEG
ALSPDGTVLA TASHDGYVKF WQIYIEGQDQ PRCLHEWQPH NGQPLSCLLF CDNHKKQDPD
VPFWRFLITG ADQNQELKMW CTVSWTCLQT IRFSPDPFNC GVLPSLKASL DLSAEFLILS
DVQRKVLYVM ELLQDQEKGR ASFTAVSEFL LTHPVLSFGV QDVSRARLRH TEVLPPEEES
ESMTAEGNQG TSESRSGIQI KLYCVHTKSL QDVQIWFQPN QGDSSSLFMP QSGSQDGFSF
SDPLADLNVE AMSSDKESGD SGSQNDLSKI LPLPSPADFM SPAPSALPKL MTPDAFMTPS
ASMPASPGSS ASSLTIVTAM SSSDSGARGG DDLTQSPKMS VECVNSSFAN AGSPRSNSIL
ISGLGENIQV SPPNPPLSLD LQAIDPMVVP QASPTRARSP DVISSASTAM SQDIPEIASE
TLQRGLSGAN ADSGPILHSD SMASAASILH LLSPRARSSA EHSLLPLELG AASVDGEQRL
SNTPSLLETA LSQENAGAAG GSCSDSSVNH AWPAAPDITR ETRNSLRDNG LGDCSREEIK
DRHISSPYHR RTYHLTQNDS QDASAEQSDH DDEVASLASS SGNCGPRSSH RLPVKDWKTS
PRSSPKLKRK SKKDEGESSQ SRQIESQMST EVQDELLQML RSQQREIAEL RQNQLDLLQR
VTSHMDAVQS SMMAHIEHAM LAQQEQEQRR MERILVEGQS RNQQLQDQLV QQLVQTLNNS
LCNRLEKVLR EEMKKTVPQT ISKSLEPVTG QMNSTIAAKL TAVEGALKEN VTKVVKSKNT
TDAIGRAAAE AMQGPIQAAY KETFQSIVLP VFERGCQSMF QQINDSFKQG TNEYIQQLET
HIKNRKQRDQ DTRDPVIGQL QQMIDSLQSS QDQLASTVTA SVSSDVQHQL HMIVGNLQDS
ILTQVQRIVK GEVSLAMKEQ QAAVTSSIMQ AMRSAAGTPV PSAHLDYQAQ QASILQLLQQ
GQLNEAFQQA LSAADLNLVL YVCETIDSQQ VFGQQPCPLH QAVLLSLIQQ LSTNLSTRTE
LKISYLEDAV MNLDHGDPVT RDHMSAVLTQ VRQKLFLFLQ QDAHSPMSKR ARRLMMMLQG
LVNH
