ID   EDC4_XENLA              Reviewed;        1391 AA.
AC   Q7ZXT3;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Enhancer of mRNA-decapping protein 4;
GN   Name=edc4;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In the process of mRNA degradation, seems to play a role in
CC       mRNA decapping. {ECO:0000250|UniProtKB:Q6P2E9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000250|UniProtKB:Q6P2E9}.
CC       Nucleus {ECO:0000250|UniProtKB:Q6P2E9}.
CC   -!- SIMILARITY: Belongs to the WD repeat EDC4 family. {ECO:0000305}.
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DR   EMBL; BC044263; AAH44263.1; -; mRNA.
DR   RefSeq; NP_001079552.1; NM_001086083.1.
DR   AlphaFoldDB; Q7ZXT3; -.
DR   PRIDE; Q7ZXT3; -.
DR   DNASU; 379239; -.
DR   GeneID; 379239; -.
DR   KEGG; xla:379239; -.
DR   CTD; 379239; -.
DR   Xenbase; XB-GENE-5839889; edc4.L.
DR   OMA; QQVNLMT; -.
DR   OrthoDB; 1424637at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 379239; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR   GO; GO:0031087; P:deadenylation-independent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR   Gene3D; 1.10.220.100; -; 1.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR045152; EDC4-like.
DR   InterPro; IPR044938; EDC4_C.
DR   InterPro; IPR032401; EDC4_WD40.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR15598; PTHR15598; 1.
DR   Pfam; PF16529; Ge1_WD40; 1.
DR   SMART; SM00320; WD40; 3.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..1391
FT                   /note="Enhancer of mRNA-decapping protein 4"
FT                   /id="PRO_0000278966"
FT   REPEAT          170..210
FT                   /note="WD 1"
FT   REPEAT          226..274
FT                   /note="WD 2"
FT   REPEAT          292..331
FT                   /note="WD 3"
FT   REPEAT          340..390
FT                   /note="WD 4"
FT   REGION          703..724
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          897..925
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          935..968
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        709..724
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        911..925
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1391 AA;  153919 MW;  5B96EDAA1F2B1E26 CRC64;
     MASVTSIDVD ATQHLRDILK LDRTEDSING NQRKSNSSFS SDLNGLLVTD QVAAVGTSLS
     DTNLCSAAVL NSERQVICLS GDDSSSCIKI TGKDVEIVAS HDSNICSKAR GSNKVKIQPV
     AKYDWEQKYY CGNLIAVSND YIAYATRGAN GSAMVRVLSL TTAERILLKG ITGSVTDLAF
     AHLKSNHLAC LDEAGSLFVW QLTMTNGKIQ DDIVVHIRRP ENTVLSIFRR IIWCPYIPEE
     NEENVVDDTS QTIALLHEDK AEVWDLEIIQ TNHNTWPVDV SEIKEGFIIV KGHSGRLSEG
     ALSPDGTVLA TASHDGYVKF WQIYIEGQDQ PRCLHEWKPH NGRPLSCLLF CDNHKKQDPE
     VPFWRFLITG ADQNRELKVW CTVSWTSLQT IQFSPDPFSS GVLPGLKASL DLSAEFLILT
     DVQRKVLYVM ELNQNQDEGK ATFTSISEFL LTHPVLSFGI QDVNHCRLRN TEVLPAEEDN
     NSINQEEILE CESVEAAAGV LIKLFCVHTK ALQDVQIWFQ PHQNAEPAIL GTAQPQQENF
     ALPDIQGINM ERMPSMQGSM HGSQSDLCRI STDFLLLPTD SVPKLMTPDA FMSPSASLQQ
     GITSPGSIIS TLTTVTPISS TSNSDTVLAR PSEEMTLSTM LQLDTSATLS NPSRDGNPLS
     NSRNPAVVIP GMSETIVSIP AAQMPSSNHP LELQDLDPLV VPQASPTRER SPDVISSAST
     AMPQDIPEIA SETLQRSYIS SVPSGLSVEG CESSHHSDSM SSAASALHLL SPHNLSSLDH
     GHRPIIIGSS VVENERISAP SLLESTIQED NVDIGLPQPW PAAPDITKET RNNLVDSSRN
     GQDRGDSSFH RHNYHLLQQH DSQDASAEQS DHDDEVASLA SISGSFGGKG QHLLIKDWKS
     KLSPRSSPKL RRKSKKDEME LAKSPRVSDH LVNLELQEEL LCMLRSQQKE LSDLRQNQLE
     LMKKLTDHMD AVQSSIMGHV ERVIDTQQEQ EQRRVERILS DGHERNGQLQ EYLSQQLSHS
     LSGSLSNRVD KIIREEMKKT VSQCISKTLD PVAAQLTSSV AAKVTAVEGV LKENVTKMVK
     SKNVTDAIGR VAADSLQTVI HSAYREAFQS IVLPAFERSC QSMFQQVNNS FKQGTQDYMQ
     QLEAHLRSIK MNEQETRDPV VTQLQQMVDS LQTVTDQLAS NITSNVRSEV QHQLHIAVGN
     MQDSILSQVQ RIIKEEVSHA MKEQQAAVTS SIMQAMRSAA GTPIPSSHMD FHSQQTHILQ
     LMQQGQINQA FQQALTASDL NLILYVCETV DPQQVFGQHP CPLTQPVLLS LIQQLSFDFG
     SRTEIKLNYL EEAVMNLDHS DPVTRDHMGT VLNQVRQKLY QFLQAEPQNA LQKPARRLLI
     MLQGLVPPTL S