ID   EDF1_DANRE              Reviewed;         146 AA.
AC   Q6PBY3;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Endothelial differentiation-related factor 1 homolog;
DE            Short=EDF-1;
GN   Name=edf1; ORFNames=zgc:73192, zgc:86829;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo, and Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable transcriptional coactivator. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; BC059541; AAH59541.1; -; mRNA.
DR   EMBL; BC071480; AAH71480.1; -; mRNA.
DR   RefSeq; NP_957039.1; NM_200745.1.
DR   AlphaFoldDB; Q6PBY3; -.
DR   SMR; Q6PBY3; -.
DR   STRING; 7955.ENSDARP00000026769; -.
DR   PaxDb; Q6PBY3; -.
DR   Ensembl; ENSDART00000015940; ENSDARP00000026769; ENSDARG00000009950.
DR   GeneID; 793036; -.
DR   KEGG; dre:793036; -.
DR   CTD; 8721; -.
DR   ZFIN; ZDB-GENE-040426-1710; edf1.
DR   eggNOG; KOG3398; Eukaryota.
DR   GeneTree; ENSGT00390000008519; -.
DR   HOGENOM; CLU_112609_0_1_1; -.
DR   InParanoid; Q6PBY3; -.
DR   OMA; NKAHQGT; -.
DR   OrthoDB; 1571466at2759; -.
DR   PhylomeDB; Q6PBY3; -.
DR   TreeFam; TF300064; -.
DR   PRO; PR:Q6PBY3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 5.
DR   Bgee; ENSDARG00000009950; Expressed in early embryo and 26 other tissues.
DR   ExpressionAtlas; Q6PBY3; baseline.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd00093; HTH_XRE; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR013729; MBF1_N.
DR   Pfam; PF01381; HTH_3; 1.
DR   Pfam; PF08523; MBF1; 1.
DR   SMART; SM00530; HTH_XRE; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS50943; HTH_CROC1; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..146
FT                   /note="Endothelial differentiation-related factor 1
FT                   homolog"
FT                   /id="PRO_0000149799"
FT   DOMAIN          80..134
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT   DNA_BIND        91..110
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT   REGION          13..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   146 AA;  16075 MW;  47289767375177E1 CRC64;
     MAECDWDTVT VLRKKGSAAQ SKSKQAVTAA QRKGEAVETS KKWAAGQNKQ HVVTKNTAKL
     DRETEELSHQ RVPLEVGKVI QQGRQNKGLT QKDLATKINE KPQIIAEYEC GKAIPNNQVM
     GKIERAIGLK LRGKDIGLPL EACSKK