ID   EDF1_XENLA              Reviewed;         147 AA.
AC   Q6GPQ6;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Endothelial differentiation-related factor 1 homolog;
DE            Short=EDF-1;
GN   Name=edf1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable transcriptional coactivator. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; BC073056; AAH73056.1; -; mRNA.
DR   RefSeq; NP_001085634.1; NM_001092165.1.
DR   AlphaFoldDB; Q6GPQ6; -.
DR   SMR; Q6GPQ6; -.
DR   DNASU; 444060; -.
DR   GeneID; 444060; -.
DR   KEGG; xla:444060; -.
DR   CTD; 444060; -.
DR   Xenbase; XB-GENE-17343925; edf1.L.
DR   OMA; DWDPIVL; -.
DR   OrthoDB; 1571466at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 444060; Expressed in pancreas and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd00093; HTH_XRE; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR013729; MBF1_N.
DR   Pfam; PF01381; HTH_3; 1.
DR   Pfam; PF08523; MBF1; 1.
DR   SMART; SM00530; HTH_XRE; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS50943; HTH_CROC1; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..147
FT                   /note="Endothelial differentiation-related factor 1
FT                   homolog"
FT                   /id="PRO_0000149800"
FT   DOMAIN          81..135
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT   DNA_BIND        92..111
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT   REGION          1..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   147 AA;  16321 MW;  6BF37A015951BC55 CRC64;
     MAESDWDTVT VLRKKGPTAA QAKSKQAITA AQRRGEEVET SKKWSAGQNK QHTITRNTAK
     LDRETEELHH DRVPLEVGKV IQQGRQGKGM TQKDLATKIN EKPQVIADYE CGKAIPNNQV
     MGKIERVIGL KLRGKDIGKP MDPGPKK