ID   EDG1_CAEEL              Reviewed;         727 AA.
AC   Q17436;
DT   10-FEB-2021, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 2.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Protein edg-1 {ECO:0000305};
DE   AltName: Full=Enlarged deps-1 granule 1 {ECO:0000312|WormBase:B0035.6};
GN   Name=edg-1 {ECO:0000312|WormBase:B0035.6};
GN   ORFNames=B0035.6 {ECO:0000312|WormBase:B0035.6};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION, INTERACTION WITH DEPS-1 AND PRG-1, SUBCELLULAR LOCATION, AND
RP   DISRUPTION PHENOTYPE.
RX   PubMed=32843637; DOI=10.1038/s41467-020-18089-1;
RA   Suen K.M., Braukmann F., Butler R., Bensaddek D., Akay A., Lin C.C.,
RA   Milonaityte D., Doshi N., Sapetschnig A., Lamond A., Ladbury J.E.,
RA   Miska E.A.;
RT   "DEPS-1 is required for piRNA-dependent silencing and PIWI condensate
RT   organisation in Caenorhabditis elegans.";
RL   Nat. Commun. 11:4242-4242(2020).
CC   -!- FUNCTION: Plays a role in regulating deps-1 cluster formation in the
CC       germline. {ECO:0000269|PubMed:32843637}.
CC   -!- SUBUNIT: May interact with deps-1 and prg-1.
CC       {ECO:0000269|PubMed:32843637}.
CC   -!- INTERACTION:
CC       Q17436; Q9XXL3: ssp-31; NbExp=4; IntAct=EBI-323809, EBI-327302;
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic granule
CC       {ECO:0000305|PubMed:32843637}.
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in enlarged deps-
CC       1-containing clusters. {ECO:0000269|PubMed:32843637}.
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DR   EMBL; BX284604; CAA97420.1; -; Genomic_DNA.
DR   PIR; T18665; T18665.
DR   RefSeq; NP_502130.1; NM_069729.6.
DR   AlphaFoldDB; Q17436; -.
DR   DIP; DIP-25751N; -.
DR   IntAct; Q17436; 2.
DR   STRING; 6239.B0035.6; -.
DR   EPD; Q17436; -.
DR   PaxDb; Q17436; -.
DR   PeptideAtlas; Q17436; -.
DR   EnsemblMetazoa; B0035.6.1; B0035.6.1; WBGene00007109.
DR   GeneID; 178047; -.
DR   KEGG; cel:CELE_B0035.6; -.
DR   UCSC; B0035.6; c. elegans.
DR   CTD; 178047; -.
DR   WormBase; B0035.6; CE20443; WBGene00007109; edg-1.
DR   eggNOG; ENOG502RT6K; Eukaryota.
DR   GeneTree; ENSGT00970000196217; -.
DR   HOGENOM; CLU_380938_0_0_1; -.
DR   InParanoid; Q17436; -.
DR   OMA; VKEWQYY; -.
DR   OrthoDB; 1233670at2759; -.
DR   PhylomeDB; Q17436; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00007109; Expressed in germ line (C elegans) and 4 other tissues.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..727
FT                   /note="Protein edg-1"
FT                   /id="PRO_0000451761"
FT   REGION          703..727
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   727 AA;  84192 MW;  FEED29C594A42F59 CRC64;
     MVENKSSYEL PDQKTLDMNK EWVQELEDIF YSYKKYDVNK VRVQQFLDRR SDFLVYDFYT
     SNLSMDAMQY FQAGVTQKDV GLSKDYILLM RKLYSMLTEP SKQFFQEQFV KEWQYHEIDY
     TPYFETLVPR FREKIARLLD EIVKNPEEVD DDVQEELRWH LLFSPVTTLL DIFTRCLKNF
     EITGFCLNVC LKVPQLFFDR PLKIYHTEYE TDRVESLMAL VFRRLIFNKR WVDTSDEEWS
     NLEQLARVIC SGQEPSLMSA WPLLEVVLCE LYTQNRTPMI SVEVLSEIAV KIVENFDNLK
     YATSARTKPA ENVLLTPSII CFLLNIIVDE NVSNTVIENC KMILKAIGQN MEQPFDAEAK
     SYLTSKVLKE FPWTLEFAIS TWFKALEVEK RRIPSAVYKA INAEMKETFD ERTFDIEESE
     TVDQSINEED EERCSTLSSE SSVKTAISID HKSDTAVDNL EMNQLHLSPK PKASVEAVKS
     CKPAFVAVIF EEIPPETDQN ISVFEDPTIE VLTEYLDCII TMGVFDISCA DELMRHSSVT
     FESSEQLEKV MKTAFEENFE IANAGPQRIK EISGKILEVF GSTSSESDHD RIASSIIELI
     PTEEYEKTGP RWSHDIKKSE IIQPLVIPVE ATLESWPPAE YRYVAPGIKE SRDSARHERL
     LRQQLATTKS LEMAQLHRDL WAENEKNMEH WTRPASPCNS SFFAESSVKP TTSSAYGNSS
     NFSRYAD