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EDL12_ARATH
ID   EDL12_ARATH             Reviewed;         462 AA.
AC   Q8VZT3; Q9MA53; Q9SCW6;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Sugar transporter ERD6-like 12;
DE   AltName: Full=Sugar transporter-like protein 5;
GN   Name=SUGTL5; OrderedLocusNames=At3g05400; ORFNames=F22F7.16;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 124-462.
RA   Gy I., Kreis M., Lecharny A.;
RT   "A novel multigene family in Arabidopsis thaliana coding for putative sugar
RT   transporters.";
RL   Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   GENE FAMILY.
RX   PubMed=16923188; DOI=10.1186/1471-2148-6-64;
RA   Johnson D.A., Hill J.P., Thomas M.A.;
RT   "The monosaccharide transporter gene family in land plants is ancient and
RT   shows differential subfamily expression and expansion across lineages.";
RL   BMC Evol. Biol. 6:64-64(2006).
CC   -!- FUNCTION: Sugar transporter. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences.;
CC       Name=1;
CC         IsoId=Q8VZT3-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC       transporter (TC 2.A.1.1) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF64542.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC009606; AAF64542.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002686; AEE74233.1; -; Genomic_DNA.
DR   EMBL; AY063856; AAL36212.1; -; mRNA.
DR   EMBL; AY091216; AAM14155.1; -; mRNA.
DR   EMBL; AJ249971; CAB64736.1; -; mRNA.
DR   RefSeq; NP_187191.2; NM_111413.5. [Q8VZT3-1]
DR   AlphaFoldDB; Q8VZT3; -.
DR   SMR; Q8VZT3; -.
DR   BioGRID; 5039; 3.
DR   IntAct; Q8VZT3; 1.
DR   STRING; 3702.AT3G05400.1; -.
DR   PaxDb; Q8VZT3; -.
DR   ProteomicsDB; 222060; -. [Q8VZT3-1]
DR   EnsemblPlants; AT3G05400.1; AT3G05400.1; AT3G05400. [Q8VZT3-1]
DR   GeneID; 819704; -.
DR   Gramene; AT3G05400.1; AT3G05400.1; AT3G05400. [Q8VZT3-1]
DR   KEGG; ath:AT3G05400; -.
DR   Araport; AT3G05400; -.
DR   TAIR; locus:2079802; AT3G05400.
DR   eggNOG; KOG0254; Eukaryota.
DR   InParanoid; Q8VZT3; -.
DR   OMA; MYSAEMT; -.
DR   OrthoDB; 430696at2759; -.
DR   PhylomeDB; Q8VZT3; -.
DR   PRO; PR:Q8VZT3; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q8VZT3; baseline and differential.
DR   Genevisible; Q8VZT3; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0051119; F:sugar transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   CDD; cd17358; MFS_GLUT6_8_Class3_like; 1.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR044775; MFS_ERD6/Tret1-like.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR003663; Sugar/inositol_transpt.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   Pfam; PF00083; Sugar_tr; 1.
DR   PRINTS; PR00171; SUGRTRNSPORT.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00879; SP; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR   PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..462
FT                   /note="Sugar transporter ERD6-like 12"
FT                   /id="PRO_0000259862"
FT   TRANSMEM        25..45
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..282
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..317
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        326..346
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..378
FT                   /note="Helical; Name=10"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        399..419
FT                   /note="Helical; Name=11"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        424..444
FT                   /note="Helical; Name=12"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   462 AA;  50602 MW;  9CB5B910AEA29D35 CRC64;
     MEGENNMEKG LLLAKKEDSA NTTPLLIFST FIIVSASFTF GAAIGYTADT MSSIMSDLDL
     SLAQFSLFGS LSTFGGMIGA IFSAKAASAF GHKMTLWVAD LFCITGWLAI SLAKDIIWLD
     MGRFLVGIGV GLISYVVPVY IAEITPKHVR GAFTFSNQLL QNCGVAVVYY FGNFLSWRTL
     AIIGSIPCWI QVIGLFFIPE SPRWLAKKGR DKECEEVLQK LRGRKYDIVP EACEIKISVE
     ASKKNSNINI RSLFEKRYAH QLTIGIGLML LQQLCGTAGI SSYGSTLFKL AGFPARIGMM
     VLSLIVVPKS LMGLILVDRW GRRPLLMTSA LGLCLSCITL AVAFGVKDVP GIGKITPIFC
     FIGILSFTMM FAIGMGALPW IIMSEIFPMD IKVLAGSLVT IANWFTGWIA NYAFNFMLVW
     SPSGTFIISA IICGATIVFT WCLVPETRRL TLEEIQLSFV NV
 
 
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