EDL12_ARATH
ID EDL12_ARATH Reviewed; 462 AA.
AC Q8VZT3; Q9MA53; Q9SCW6;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Sugar transporter ERD6-like 12;
DE AltName: Full=Sugar transporter-like protein 5;
GN Name=SUGTL5; OrderedLocusNames=At3g05400; ORFNames=F22F7.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 124-462.
RA Gy I., Kreis M., Lecharny A.;
RT "A novel multigene family in Arabidopsis thaliana coding for putative sugar
RT transporters.";
RL Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=16923188; DOI=10.1186/1471-2148-6-64;
RA Johnson D.A., Hill J.P., Thomas M.A.;
RT "The monosaccharide transporter gene family in land plants is ancient and
RT shows differential subfamily expression and expansion across lineages.";
RL BMC Evol. Biol. 6:64-64(2006).
CC -!- FUNCTION: Sugar transporter. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q8VZT3-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF64542.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC009606; AAF64542.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE74233.1; -; Genomic_DNA.
DR EMBL; AY063856; AAL36212.1; -; mRNA.
DR EMBL; AY091216; AAM14155.1; -; mRNA.
DR EMBL; AJ249971; CAB64736.1; -; mRNA.
DR RefSeq; NP_187191.2; NM_111413.5. [Q8VZT3-1]
DR AlphaFoldDB; Q8VZT3; -.
DR SMR; Q8VZT3; -.
DR BioGRID; 5039; 3.
DR IntAct; Q8VZT3; 1.
DR STRING; 3702.AT3G05400.1; -.
DR PaxDb; Q8VZT3; -.
DR ProteomicsDB; 222060; -. [Q8VZT3-1]
DR EnsemblPlants; AT3G05400.1; AT3G05400.1; AT3G05400. [Q8VZT3-1]
DR GeneID; 819704; -.
DR Gramene; AT3G05400.1; AT3G05400.1; AT3G05400. [Q8VZT3-1]
DR KEGG; ath:AT3G05400; -.
DR Araport; AT3G05400; -.
DR TAIR; locus:2079802; AT3G05400.
DR eggNOG; KOG0254; Eukaryota.
DR InParanoid; Q8VZT3; -.
DR OMA; MYSAEMT; -.
DR OrthoDB; 430696at2759; -.
DR PhylomeDB; Q8VZT3; -.
DR PRO; PR:Q8VZT3; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q8VZT3; baseline and differential.
DR Genevisible; Q8VZT3; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0051119; F:sugar transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR CDD; cd17358; MFS_GLUT6_8_Class3_like; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR044775; MFS_ERD6/Tret1-like.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..462
FT /note="Sugar transporter ERD6-like 12"
FT /id="PRO_0000259862"
FT TRANSMEM 25..45
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 358..378
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..419
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..444
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
SQ SEQUENCE 462 AA; 50602 MW; 9CB5B910AEA29D35 CRC64;
MEGENNMEKG LLLAKKEDSA NTTPLLIFST FIIVSASFTF GAAIGYTADT MSSIMSDLDL
SLAQFSLFGS LSTFGGMIGA IFSAKAASAF GHKMTLWVAD LFCITGWLAI SLAKDIIWLD
MGRFLVGIGV GLISYVVPVY IAEITPKHVR GAFTFSNQLL QNCGVAVVYY FGNFLSWRTL
AIIGSIPCWI QVIGLFFIPE SPRWLAKKGR DKECEEVLQK LRGRKYDIVP EACEIKISVE
ASKKNSNINI RSLFEKRYAH QLTIGIGLML LQQLCGTAGI SSYGSTLFKL AGFPARIGMM
VLSLIVVPKS LMGLILVDRW GRRPLLMTSA LGLCLSCITL AVAFGVKDVP GIGKITPIFC
FIGILSFTMM FAIGMGALPW IIMSEIFPMD IKVLAGSLVT IANWFTGWIA NYAFNFMLVW
SPSGTFIISA IICGATIVFT WCLVPETRRL TLEEIQLSFV NV