EDL14_ARATH
ID EDL14_ARATH Reviewed; 482 AA.
AC Q8GXK5; Q9M100; Q9ZS99;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2006, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Sugar transporter ERD6-like 14;
GN OrderedLocusNames=At4g04750; ORFNames=T4B21.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP GENE FAMILY.
RX PubMed=16923188; DOI=10.1186/1471-2148-6-64;
RA Johnson D.A., Hill J.P., Thomas M.A.;
RT "The monosaccharide transporter gene family in land plants is ancient and
RT shows differential subfamily expression and expansion across lineages.";
RL BMC Evol. Biol. 6:64-64(2006).
CC -!- FUNCTION: Sugar transporter. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8GXK5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8GXK5-2; Sequence=VSP_021552;
CC -!- MISCELLANEOUS: [Isoform 2]: Incomplete sequence. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD03450.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB80840.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF118223; AAD03450.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161501; CAB80840.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE82421.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM67187.1; -; Genomic_DNA.
DR EMBL; AK118190; BAC42813.1; -; mRNA.
DR PIR; G85059; G85059.
DR RefSeq; NP_001329031.1; NM_001340507.1. [Q8GXK5-1]
DR RefSeq; NP_192384.2; NM_116713.3. [Q8GXK5-1]
DR AlphaFoldDB; Q8GXK5; -.
DR SMR; Q8GXK5; -.
DR BioGRID; 11122; 26.
DR IntAct; Q8GXK5; 26.
DR STRING; 3702.AT4G04750.1; -.
DR PaxDb; Q8GXK5; -.
DR ProteomicsDB; 224724; -. [Q8GXK5-1]
DR EnsemblPlants; AT4G04750.1; AT4G04750.1; AT4G04750. [Q8GXK5-1]
DR EnsemblPlants; AT4G04750.2; AT4G04750.2; AT4G04750. [Q8GXK5-1]
DR GeneID; 825811; -.
DR Gramene; AT4G04750.1; AT4G04750.1; AT4G04750. [Q8GXK5-1]
DR Gramene; AT4G04750.2; AT4G04750.2; AT4G04750. [Q8GXK5-1]
DR KEGG; ath:AT4G04750; -.
DR Araport; AT4G04750; -.
DR TAIR; locus:2138927; AT4G04750.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_001265_30_5_1; -.
DR InParanoid; Q8GXK5; -.
DR PhylomeDB; Q8GXK5; -.
DR PRO; PR:Q8GXK5; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q8GXK5; baseline and differential.
DR Genevisible; Q8GXK5; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IDA:TAIR.
DR GO; GO:0051119; F:sugar transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR CDD; cd17358; MFS_GLUT6_8_Class3_like; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR044775; MFS_ERD6/Tret1-like.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..482
FT /note="Sugar transporter ERD6-like 14"
FT /id="PRO_0000259864"
FT TRANSMEM 36..56
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 436..456
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 304..482
FT /note="GVSSDIGFILTSIVQMTGGVLGVLLVDISGRRSLLLFSQAGMFLGCLATAIS
FT FFLQKNNCWETGTPIMALISVMVYFGSYGLGMGPIPWIIASEIYPVDVKGAAGTVCNLV
FT TSISSWLVTYSFNFLLQWSSTGTFMMFATVMGLGFVFTAKLVPETKGKSLEEIQSAFTD
FT STSEDSTIF -> DDWRRFRCFACGYIRKTFSPTVFSSWNVLGLSSNSHFILLAEEQLL
FT GNRNTNNGSH (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_021552"
FT CONFLICT 269
FT /note="K -> R (in Ref. 3; BAC42813)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 482 AA; 51677 MW; 4BC40F375F7F8239 CRC64;
MAEESLLPSH TEDVSASPNK SSSLLSEISN ASTRPFVLAF TVGSCGALSF GCIVGYTAPT
QSSIMKDLNL SIADFSFFGS ILTVGLILGA LICGKLADLV GRVYTIWITN ILVLIGWLAI
AFAKDVRLLD LGRLLQGISV GISSYLGPIY ISELAPRNLR GAASSLMQLF VGVGLSAFYA
LGTAVAWRSL AILGSIPSLV VLPLLFFIPE SPRWLAKVGR EKEVEGVLLS LRGAKSDVSD
EAATILEYTK HVEQQDIDSR GFFKLFQRKY ALPLTIGVVL ISMPQLGGLN GYTFYTDTIF
TSTGVSSDIG FILTSIVQMT GGVLGVLLVD ISGRRSLLLF SQAGMFLGCL ATAISFFLQK
NNCWETGTPI MALISVMVYF GSYGLGMGPI PWIIASEIYP VDVKGAAGTV CNLVTSISSW
LVTYSFNFLL QWSSTGTFMM FATVMGLGFV FTAKLVPETK GKSLEEIQSA FTDSTSEDST
IF
