EDL18_ARATH
ID EDL18_ARATH Reviewed; 478 AA.
AC Q94CI6;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Sugar transporter ERD6-like 18;
DE AltName: Full=Sugar-porter family protein 2;
GN Name=SFP2; OrderedLocusNames=At5g27360; ORFNames=F21A20.70;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=11485201; DOI=10.1023/a:1010639015959;
RA Quirino B.F., Reiter W.-D., Amasino R.M.;
RT "One of two tandem Arabidopsis genes homologous to monosaccharide
RT transporters is senescence-associated.";
RL Plant Mol. Biol. 46:447-457(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY.
RX PubMed=16923188; DOI=10.1186/1471-2148-6-64;
RA Johnson D.A., Hill J.P., Thomas M.A.;
RT "The monosaccharide transporter gene family in land plants is ancient and
RT shows differential subfamily expression and expansion across lineages.";
RL BMC Evol. Biol. 6:64-64(2006).
CC -!- FUNCTION: Sugar transporter. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in leaf vasculature, stem and flowers.
CC {ECO:0000269|PubMed:11485201}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; AY026255; AAK11721.1; -; mRNA.
DR EMBL; AC007123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED93676.1; -; Genomic_DNA.
DR RefSeq; NP_568494.1; NM_122618.3.
DR AlphaFoldDB; Q94CI6; -.
DR SMR; Q94CI6; -.
DR STRING; 3702.AT5G27360.1; -.
DR PaxDb; Q94CI6; -.
DR PRIDE; Q94CI6; -.
DR ProteomicsDB; 222063; -.
DR EnsemblPlants; AT5G27360.1; AT5G27360.1; AT5G27360.
DR GeneID; 832795; -.
DR Gramene; AT5G27360.1; AT5G27360.1; AT5G27360.
DR KEGG; ath:AT5G27360; -.
DR Araport; AT5G27360; -.
DR TAIR; locus:2146365; AT5G27360.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_001265_30_5_1; -.
DR InParanoid; Q94CI6; -.
DR OMA; ECKGRSM; -.
DR PhylomeDB; Q94CI6; -.
DR PRO; PR:Q94CI6; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q94CI6; baseline and differential.
DR Genevisible; Q94CI6; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0051119; F:sugar transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR CDD; cd17358; MFS_GLUT6_8_Class3_like; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR044775; MFS_ERD6/Tret1-like.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..478
FT /note="Sugar transporter ERD6-like 18"
FT /id="PRO_0000259868"
FT TRANSMEM 31..51
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..180
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 333..353
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 367..387
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 407..427
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 433..453
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
SQ SEQUENCE 478 AA; 52461 MW; A7F83C5FE3AED6D9 CRC64;
MHKMMVVEKE RSIEERLLQL KNQNDDSECR ITACVILSTF IAVCGSFSFG VSLGYTSGAE
IGIMKDLDLS IAQFSAFASL STLGAAIGAL FSGKMAIILG RRKTMWVSDL LCIIGWFSIA
FAKDVMWLNF GRISSGIGLG LISYVVPVYI AEISPKHVRG TFTFTNQLLQ NSGLAMVYFS
GNFLNWRILA LLGALPCFIQ VIGLFFVPES PRWLAKVGSD KELENSLLRL RGGNADISRE
ASDIEVMTKM VENDSKSSFC DLFQRKYRYT LVVGIGLMLI QQFSGSSAVL SYASTILRKA
GFSVTIGSTL LGLFMIPKAM IGVILVDKWG RRPLLLTSVS GMCITSMLIG VAFTLQKMQL
LPELTPVFTF ICVTLYIGTY AIGLGGLPWV IMSEIFPMNI KVTAGSIVTL VSWSSSSIVT
YAFNFLLEWS TQGTFYVFGA VGGLALLFIW LLVPETKGLS LEEIQASLIR EPDRINQS
