EDN1_CANLF
ID EDN1_CANLF Reviewed; 202 AA.
AC P13206; Q765Z3; Q9BDC1;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Endothelin-1;
DE Short=ET-1;
DE AltName: Full=Preproendothelin-1;
DE Short=PPET1;
DE Contains:
DE RecName: Full=Big endothelin-1;
DE Flags: Precursor;
GN Name=EDN1;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Uchide T.;
RT "Cloning of canine preproendothelin-1 cDNA.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-78.
RC TISSUE=Liver;
RX PubMed=2657658; DOI=10.1093/nar/17.8.3290;
RA Kimura C., Itoh Y., Ohkubo S., Ogi K., Onda H., Fujino M.;
RT "Cloning and sequencing of a canine gene segment encoding mature
RT endothelin.";
RL Nucleic Acids Res. 17:3290-3290(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE OF 27-122.
RC TISSUE=Heart;
RA Biondo A.W., Wiedmeyer C.E., Solter P.F., Sisson D.D.;
RT "Canis familiaris endothelin-1 and big endothelin-1 cDNA.";
RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Endothelins are endothelium-derived vasoconstrictor peptides
CC (By similarity). Probable ligand for G-protein coupled receptors EDNRA
CC and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and
CC RHOA cascade in glomerular mesangial cells (By similarity). Also binds
CC the DEAR/FBXW7-AS1 receptor (By similarity).
CC {ECO:0000250|UniProtKB:P05305, ECO:0000250|UniProtKB:P09558}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the endothelin/sarafotoxin family.
CC {ECO:0000305}.
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DR EMBL; AB115087; BAD02920.1; -; mRNA.
DR EMBL; X14610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF333433; AAK01932.1; -; mRNA.
DR PIR; S04074; S04074.
DR RefSeq; NP_001002956.1; NM_001002956.1.
DR AlphaFoldDB; P13206; -.
DR BMRB; P13206; -.
DR STRING; 9615.ENSCAFP00000014389; -.
DR PaxDb; P13206; -.
DR Ensembl; ENSCAFT00030012876; ENSCAFP00030011253; ENSCAFG00030006988.
DR Ensembl; ENSCAFT00040031779; ENSCAFP00040027638; ENSCAFG00040017186.
DR Ensembl; ENSCAFT00845037679; ENSCAFP00845029523; ENSCAFG00845021350.
DR GeneID; 403424; -.
DR KEGG; cfa:403424; -.
DR CTD; 1906; -.
DR VEuPathDB; HostDB:ENSCAFG00845021350; -.
DR eggNOG; ENOG502S1NV; Eukaryota.
DR GeneTree; ENSGT00950000183053; -.
DR HOGENOM; CLU_090013_1_0_1; -.
DR InParanoid; P13206; -.
DR OMA; RCQCANQ; -.
DR OrthoDB; 1264335at2759; -.
DR TreeFam; TF333184; -.
DR Reactome; R-CFA-375276; Peptide ligand-binding receptors.
DR Reactome; R-CFA-416476; G alpha (q) signalling events.
DR Proteomes; UP000002254; Chromosome 35.
DR Bgee; ENSCAFG00000009794; Expressed in placenta and 45 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IEA:Ensembl.
DR GO; GO:0031707; F:endothelin A receptor binding; IBA:GO_Central.
DR GO; GO:0031708; F:endothelin B receptor binding; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0014824; P:artery smooth muscle contraction; IEA:Ensembl.
DR GO; GO:0048675; P:axon extension; IEA:Ensembl.
DR GO; GO:0060385; P:axonogenesis involved in innervation; IEA:Ensembl.
DR GO; GO:0007589; P:body fluid secretion; IEA:Ensembl.
DR GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IEA:Ensembl.
DR GO; GO:0070588; P:calcium ion transmembrane transport; IEA:Ensembl.
DR GO; GO:0019722; P:calcium-mediated signaling; IEA:Ensembl.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0003253; P:cardiac neural crest cell migration involved in outflow tract morphogenesis; IEA:Ensembl.
DR GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central.
DR GO; GO:0071372; P:cellular response to follicle-stimulating hormone stimulus; IEA:Ensembl.
DR GO; GO:0044751; P:cellular response to human chorionic gonadotropin stimulus; IEA:Ensembl.
DR GO; GO:0070301; P:cellular response to hydrogen peroxide; IEA:Ensembl.
DR GO; GO:0071373; P:cellular response to luteinizing hormone stimulus; IEA:Ensembl.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Ensembl.
DR GO; GO:0035050; P:embryonic heart tube development; IEA:Ensembl.
DR GO; GO:0086100; P:endothelin receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0086101; P:endothelin receptor signaling pathway involved in heart process; IEA:Ensembl.
DR GO; GO:0070371; P:ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0048016; P:inositol phosphate-mediated signaling; IEA:Ensembl.
DR GO; GO:1903537; P:meiotic cell cycle process involved in oocyte maturation; IEA:Ensembl.
DR GO; GO:0042474; P:middle ear morphogenesis; IEA:Ensembl.
DR GO; GO:0007005; P:mitochondrion organization; IEA:Ensembl.
DR GO; GO:0010259; P:multicellular organism aging; IEA:Ensembl.
DR GO; GO:0051771; P:negative regulation of nitric-oxide synthase biosynthetic process; IEA:Ensembl.
DR GO; GO:0051248; P:negative regulation of protein metabolic process; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0014034; P:neural crest cell fate commitment; IEA:Ensembl.
DR GO; GO:0030185; P:nitric oxide transport; IEA:Ensembl.
DR GO; GO:0003357; P:noradrenergic neuron differentiation; IEA:Ensembl.
DR GO; GO:0030072; P:peptide hormone secretion; IEA:Ensembl.
DR GO; GO:0061626; P:pharyngeal arch artery morphogenesis; IEA:Ensembl.
DR GO; GO:0014065; P:phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
DR GO; GO:0031583; P:phospholipase D-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:2001259; P:positive regulation of cation channel activity; IEA:Ensembl.
DR GO; GO:0061051; P:positive regulation of cell growth involved in cardiac muscle cell development; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0045793; P:positive regulation of cell size; IEA:Ensembl.
DR GO; GO:0070101; P:positive regulation of chemokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; IEA:Ensembl.
DR GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IEA:Ensembl.
DR GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR GO; GO:0046887; P:positive regulation of hormone secretion; IEA:Ensembl.
DR GO; GO:0043507; P:positive regulation of JUN kinase activity; IEA:Ensembl.
DR GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR GO; GO:0060585; P:positive regulation of prostaglandin-endoperoxide synthase activity; IBA:GO_Central.
DR GO; GO:0035815; P:positive regulation of renal sodium excretion; IEA:Ensembl.
DR GO; GO:0060298; P:positive regulation of sarcomere organization; IEA:Ensembl.
DR GO; GO:2000273; P:positive regulation of signaling receptor activity; IEA:Ensembl.
DR GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0045987; P:positive regulation of smooth muscle contraction; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0035810; P:positive regulation of urine volume; IEA:Ensembl.
DR GO; GO:0001516; P:prostaglandin biosynthetic process; IEA:Ensembl.
DR GO; GO:0010737; P:protein kinase A signaling; IEA:Ensembl.
DR GO; GO:0042313; P:protein kinase C deactivation; IEA:Ensembl.
DR GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0006468; P:protein phosphorylation; IEA:Ensembl.
DR GO; GO:0010827; P:regulation of glucose transmembrane transport; IEA:Ensembl.
DR GO; GO:0006885; P:regulation of pH; IEA:Ensembl.
DR GO; GO:0003100; P:regulation of systemic arterial blood pressure by endothelin; IBA:GO_Central.
DR GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
DR GO; GO:0070294; P:renal sodium ion absorption; IEA:Ensembl.
DR GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IEA:Ensembl.
DR GO; GO:0001975; P:response to amphetamine; IEA:Ensembl.
DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR GO; GO:0043179; P:rhythmic excitation; IEA:Ensembl.
DR GO; GO:1902287; P:semaphorin-plexin signaling pathway involved in axon guidance; IEA:Ensembl.
DR GO; GO:0097492; P:sympathetic neuron axon guidance; IEA:Ensembl.
DR GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0014826; P:vein smooth muscle contraction; IBA:GO_Central.
DR InterPro; IPR020475; Endothelin.
DR InterPro; IPR019764; Endothelin_toxin_CS.
DR InterPro; IPR001928; Endothln-like_toxin.
DR PANTHER; PTHR13874; PTHR13874; 1.
DR Pfam; PF00322; Endothelin; 1.
DR PRINTS; PR00365; ENDOTHELIN.
DR SMART; SM00272; END; 2.
DR PROSITE; PS00270; ENDOTHELIN; 2.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Reference proteome;
KW Secreted; Signal; Vasoactive; Vasoconstrictor.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT PROPEP 26..50
FT /evidence="ECO:0000250|UniProtKB:P22388"
FT /id="PRO_0000008049"
FT PEPTIDE 53..91
FT /note="Big endothelin-1"
FT /evidence="ECO:0000250|UniProtKB:P22388"
FT /id="PRO_0000436394"
FT PEPTIDE 53..73
FT /note="Endothelin-1"
FT /id="PRO_0000008050"
FT PROPEP 74..202
FT /id="PRO_0000008051"
FT REGION 28..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 110..124
FT /note="Endothelin-like"
FT REGION 135..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 73..74
FT /note="Cleavage; by KEL"
FT /evidence="ECO:0000250|UniProtKB:P05305"
FT DISULFID 53..67
FT /evidence="ECO:0000250|UniProtKB:P05305"
FT DISULFID 55..63
FT /evidence="ECO:0000250|UniProtKB:P05305"
FT CONFLICT 122
FT /note="T -> N (in Ref. 3; AAK01932)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 202 AA; 22977 MW; 2EE08049230C2FD0 CRC64;
MDYFPMIFSL LFVAFQGAPE AAVLGAELST GPDSRGEKPA PSAPWRPRRS KRCSCSSLMD
KECVYFCHLD IIWVNTPEHI VPYGLGSPSR SKRSLKDLFI TKATDHRKRC QCASQKDKKC
WTFCQAGKEL REQDSMEKGW NGHKKGKDCS ELGEKSKQQQ LVAGRKIRRL DAISNSIKTA
FRVAKLKAEL YRENKVTHNR TH
