ID   EDN1_MACFA              Reviewed;          76 AA.
AC   Q28469;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Endothelin-1;
DE            Short=ET-1;
DE   Flags: Fragment;
GN   Name=EDN1;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8964809; DOI=10.1097/00004647-199607000-00020;
RA   Hino A., Tokuyama Y., Kobayashi M., Yano M., Weir B., Takeda J., Wang X.,
RA   Bell G.I., Macdonald R.L.;
RT   "Increased expression of endothelin B receptor mRNA following subarachnoid
RT   hemorrhage in monkeys.";
RL   J. Cereb. Blood Flow Metab. 16:688-697(1996).
CC   -!- FUNCTION: Endothelins are endothelium-derived vasoconstrictor peptides
CC       (By similarity). Probable ligand for G-protein coupled receptors EDNRA
CC       and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and
CC       RHOA cascade in glomerular mesangial cells (By similarity). Also binds
CC       the DEAR/FBXW7-AS1 receptor (By similarity).
CC       {ECO:0000250|UniProtKB:P05305, ECO:0000250|UniProtKB:P09558}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the endothelin/sarafotoxin family.
CC       {ECO:0000305}.
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DR   EMBL; U20579; AAA62438.1; -; Genomic_DNA.
DR   PIR; G02934; G02934.
DR   AlphaFoldDB; Q28469; -.
DR   STRING; 9541.XP_005554084.1; -.
DR   eggNOG; ENOG502S1NV; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0086100; P:endothelin receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
DR   GO; GO:0042310; P:vasoconstriction; IEA:UniProtKB-KW.
DR   InterPro; IPR020475; Endothelin.
DR   InterPro; IPR019764; Endothelin_toxin_CS.
DR   InterPro; IPR001928; Endothln-like_toxin.
DR   PANTHER; PTHR13874; PTHR13874; 1.
DR   SMART; SM00272; END; 1.
DR   PROSITE; PS00270; ENDOTHELIN; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Reference proteome; Secreted;
KW   Vasoactive; Vasoconstrictor.
FT   CHAIN           <1..>76
FT                   /note="Endothelin-1"
FT                   /id="PRO_0000146840"
FT   REGION          30..44
FT                   /note="Endothelin-like"
FT   NON_TER         1
FT   NON_TER         76
SQ   SEQUENCE   76 AA;  8625 MW;  BA403AB9DBA654C2 CRC64;
     VVPYGLGSPR SKRALENLLP TKATDRENRC QCASQKDKKC WNFCQAGKEL RAKDLMEKGW
     NNHKKGKDCS KLGKKC