ID   EDN1_RABIT              Reviewed;         202 AA.
AC   P29560;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Endothelin-1;
DE            Short=ET-1;
DE   AltName: Full=Preproendothelin-1;
DE            Short=PPET1;
DE   Contains:
DE     RecName: Full=Big endothelin-1;
DE   Flags: Precursor;
GN   Name=EDN1;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1339290; DOI=10.1016/0167-4781(92)90499-p;
RA   Marsden P.A., Sultan P., Cybulsky M., Gimbrone M.A. Jr., Brenner B.M.,
RA   Collins T.;
RT   "Nucleotide sequence of endothelin-1 cDNA from rabbit endothelial cells.";
RL   Biochim. Biophys. Acta 1129:249-250(1992).
CC   -!- FUNCTION: Endothelins are endothelium-derived vasoconstrictor peptides
CC       (By similarity). Probable ligand for G-protein coupled receptors EDNRA
CC       and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and
CC       RHOA cascade in glomerular mesangial cells (By similarity). Also binds
CC       the DEAR/FBXW7-AS1 receptor (By similarity).
CC       {ECO:0000250|UniProtKB:P05305, ECO:0000250|UniProtKB:P09558}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the endothelin/sarafotoxin family.
CC       {ECO:0000305}.
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DR   EMBL; X59931; CAA42555.1; -; mRNA.
DR   PIR; S20609; S20609.
DR   RefSeq; NP_001095166.1; NM_001101696.1.
DR   AlphaFoldDB; P29560; -.
DR   STRING; 9986.ENSOCUP00000011526; -.
DR   Ensembl; ENSOCUT00000013396; ENSOCUP00000011526; ENSOCUG00000013396.
DR   GeneID; 100009270; -.
DR   KEGG; ocu:100009270; -.
DR   CTD; 1906; -.
DR   eggNOG; ENOG502S1NV; Eukaryota.
DR   GeneTree; ENSGT00950000183053; -.
DR   HOGENOM; CLU_090013_1_0_1; -.
DR   InParanoid; P29560; -.
DR   OMA; RCQCANQ; -.
DR   OrthoDB; 1264335at2759; -.
DR   TreeFam; TF333184; -.
DR   Proteomes; UP000001811; Chromosome 12.
DR   Bgee; ENSOCUG00000013396; Expressed in upper lobe of left lung and 17 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0005125; F:cytokine activity; IEA:Ensembl.
DR   GO; GO:0031707; F:endothelin A receptor binding; IEA:Ensembl.
DR   GO; GO:0031708; F:endothelin B receptor binding; IEA:Ensembl.
DR   GO; GO:0005179; F:hormone activity; IEA:Ensembl.
DR   GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0014824; P:artery smooth muscle contraction; IEA:Ensembl.
DR   GO; GO:0048675; P:axon extension; IEA:Ensembl.
DR   GO; GO:0060385; P:axonogenesis involved in innervation; IEA:Ensembl.
DR   GO; GO:0007589; P:body fluid secretion; IEA:Ensembl.
DR   GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IEA:Ensembl.
DR   GO; GO:0070588; P:calcium ion transmembrane transport; IEA:Ensembl.
DR   GO; GO:0019722; P:calcium-mediated signaling; IEA:Ensembl.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0003253; P:cardiac neural crest cell migration involved in outflow tract morphogenesis; IEA:Ensembl.
DR   GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR   GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
DR   GO; GO:0071372; P:cellular response to follicle-stimulating hormone stimulus; IEA:Ensembl.
DR   GO; GO:0044751; P:cellular response to human chorionic gonadotropin stimulus; IEA:Ensembl.
DR   GO; GO:0070301; P:cellular response to hydrogen peroxide; IEA:Ensembl.
DR   GO; GO:0071373; P:cellular response to luteinizing hormone stimulus; IEA:Ensembl.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Ensembl.
DR   GO; GO:0035050; P:embryonic heart tube development; IEA:Ensembl.
DR   GO; GO:0086101; P:endothelin receptor signaling pathway involved in heart process; IEA:Ensembl.
DR   GO; GO:0070371; P:ERK1 and ERK2 cascade; IEA:Ensembl.
DR   GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
DR   GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR   GO; GO:0048016; P:inositol phosphate-mediated signaling; IEA:Ensembl.
DR   GO; GO:1903537; P:meiotic cell cycle process involved in oocyte maturation; IEA:Ensembl.
DR   GO; GO:0042474; P:middle ear morphogenesis; IEA:Ensembl.
DR   GO; GO:0007005; P:mitochondrion organization; IEA:Ensembl.
DR   GO; GO:0010259; P:multicellular organism aging; IEA:Ensembl.
DR   GO; GO:0051771; P:negative regulation of nitric-oxide synthase biosynthetic process; IEA:Ensembl.
DR   GO; GO:0051248; P:negative regulation of protein metabolic process; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0014034; P:neural crest cell fate commitment; IEA:Ensembl.
DR   GO; GO:0030185; P:nitric oxide transport; IEA:Ensembl.
DR   GO; GO:0003357; P:noradrenergic neuron differentiation; IEA:Ensembl.
DR   GO; GO:0030072; P:peptide hormone secretion; IEA:Ensembl.
DR   GO; GO:0061626; P:pharyngeal arch artery morphogenesis; IEA:Ensembl.
DR   GO; GO:0014065; P:phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
DR   GO; GO:0031583; P:phospholipase D-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:2001259; P:positive regulation of cation channel activity; IEA:Ensembl.
DR   GO; GO:0061051; P:positive regulation of cell growth involved in cardiac muscle cell development; IEA:Ensembl.
DR   GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR   GO; GO:0045793; P:positive regulation of cell size; IEA:Ensembl.
DR   GO; GO:0070101; P:positive regulation of chemokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; IEA:Ensembl.
DR   GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IEA:Ensembl.
DR   GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0046887; P:positive regulation of hormone secretion; IEA:Ensembl.
DR   GO; GO:0043507; P:positive regulation of JUN kinase activity; IEA:Ensembl.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR   GO; GO:0060585; P:positive regulation of prostaglandin-endoperoxide synthase activity; IEA:Ensembl.
DR   GO; GO:0035815; P:positive regulation of renal sodium excretion; IEA:Ensembl.
DR   GO; GO:0060298; P:positive regulation of sarcomere organization; IEA:Ensembl.
DR   GO; GO:2000273; P:positive regulation of signaling receptor activity; IEA:Ensembl.
DR   GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl.
DR   GO; GO:0045987; P:positive regulation of smooth muscle contraction; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0035810; P:positive regulation of urine volume; IEA:Ensembl.
DR   GO; GO:0001516; P:prostaglandin biosynthetic process; IEA:Ensembl.
DR   GO; GO:0010737; P:protein kinase A signaling; IEA:Ensembl.
DR   GO; GO:0042313; P:protein kinase C deactivation; IEA:Ensembl.
DR   GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:Ensembl.
DR   GO; GO:0010827; P:regulation of glucose transmembrane transport; IEA:Ensembl.
DR   GO; GO:0006885; P:regulation of pH; IEA:Ensembl.
DR   GO; GO:0003100; P:regulation of systemic arterial blood pressure by endothelin; IEA:Ensembl.
DR   GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
DR   GO; GO:0070294; P:renal sodium ion absorption; IEA:Ensembl.
DR   GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IEA:Ensembl.
DR   GO; GO:0001975; P:response to amphetamine; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0043179; P:rhythmic excitation; IEA:Ensembl.
DR   GO; GO:1902287; P:semaphorin-plexin signaling pathway involved in axon guidance; IEA:Ensembl.
DR   GO; GO:0097492; P:sympathetic neuron axon guidance; IEA:Ensembl.
DR   GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0014826; P:vein smooth muscle contraction; IEA:Ensembl.
DR   InterPro; IPR020475; Endothelin.
DR   InterPro; IPR019764; Endothelin_toxin_CS.
DR   InterPro; IPR001928; Endothln-like_toxin.
DR   PANTHER; PTHR13874; PTHR13874; 1.
DR   Pfam; PF00322; Endothelin; 1.
DR   PRINTS; PR00365; ENDOTHELIN.
DR   SMART; SM00272; END; 2.
DR   PROSITE; PS00270; ENDOTHELIN; 2.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Reference proteome;
KW   Secreted; Signal; Vasoactive; Vasoconstrictor.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PROPEP          24..50
FT                   /evidence="ECO:0000250|UniProtKB:P22388"
FT                   /id="PRO_0000008069"
FT   PEPTIDE         53..91
FT                   /note="Big endothelin-1"
FT                   /evidence="ECO:0000250|UniProtKB:P22388"
FT                   /id="PRO_0000436398"
FT   PEPTIDE         53..73
FT                   /note="Endothelin-1"
FT                   /id="PRO_0000008070"
FT   PROPEP          74..202
FT                   /id="PRO_0000008071"
FT   REGION          24..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          110..124
FT                   /note="Endothelin-like"
FT   SITE            73..74
FT                   /note="Cleavage; by KEL"
FT                   /evidence="ECO:0000250|UniProtKB:P05305"
FT   DISULFID        53..67
FT                   /evidence="ECO:0000250|UniProtKB:P05305"
FT   DISULFID        55..63
FT                   /evidence="ECO:0000250|UniProtKB:P05305"
SQ   SEQUENCE   202 AA;  22828 MW;  22B41EA286D51286 CRC64;
     MDYFSMMVSL LLVAFHGAPE TAASGTELST GAENPGEKPP ASAPWRPRRS KRCSCSSLMD
     KECVYFCHLD IIWVNTPGHI VPYGLGSPSR SKRSLKDLFP TRAAYHKNRC QCTSPHDKKC
     WNFCQAGTEL RAQETMEKGR NNLKKGKDCS KLGKKCILQK LMQGRKIRRL EAISNSIKTS
     FHAAQLRAQL HREQKVTHNR TH