ID   EDN2_ATEAB              Reviewed;         180 AA.
AC   Q5NRP8;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Endothelin-2;
DE            Short=ET-2;
DE   AltName: Full=Preproendothelin-2;
DE            Short=PPET2;
DE   Flags: Precursor;
GN   Name=EDN2;
OS   Atelerix albiventris (Middle-African hedgehog) (Four-toed hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae; Atelerix.
OX   NCBI_TaxID=9368;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Uchide T.;
RT   "Cloning of hedgehog preproendothelin-2 cDNA.";
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Endothelins are endothelium-derived vasoconstrictor peptides.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the endothelin/sarafotoxin family.
CC       {ECO:0000305}.
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DR   EMBL; AB197701; BAD83373.1; -; mRNA.
DR   AlphaFoldDB; Q5NRP8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
DR   GO; GO:0042310; P:vasoconstriction; IEA:UniProtKB-KW.
DR   InterPro; IPR020475; Endothelin.
DR   InterPro; IPR019764; Endothelin_toxin_CS.
DR   InterPro; IPR001928; Endothln-like_toxin.
DR   InterPro; IPR015658; ET-2.
DR   PANTHER; PTHR13874; PTHR13874; 1.
DR   PANTHER; PTHR13874:SF9; PTHR13874:SF9; 1.
DR   Pfam; PF00322; Endothelin; 1.
DR   PRINTS; PR00365; ENDOTHELIN.
DR   SMART; SM00272; END; 2.
DR   PROSITE; PS00270; ENDOTHELIN; 2.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Secreted; Signal;
KW   Vasoactive; Vasoconstrictor.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   PROPEP          27..47
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000008078"
FT   PEPTIDE         50..70
FT                   /note="Endothelin-2"
FT                   /id="PRO_0000008079"
FT   PROPEP          71..180
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000008080"
FT   REGION          97..112
FT                   /note="Endothelin-like"
FT   REGION          157..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            70..71
FT                   /note="Cleavage; by KEL"
FT                   /evidence="ECO:0000250"
FT   DISULFID        50..64
FT                   /evidence="ECO:0000250"
FT   DISULFID        52..60
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   180 AA;  20382 MW;  08BBC520F8CFC753 CRC64;
     MVALPTAWCS VALALLVALH EGKSQSAATS EEPPAPSARA RGSHLRLRRC SCNSWLDKEC
     VYFCHLDIIW VNTPGQTAPY GLGNPPRRQR RSLPRRCECY STRDSACVTF CHQKPWPKAS
     AVPGEGSPTD LLWTSKTRTT AGELLRRLRD IFAAKRNFTR HQQQKATREP ESSHSRWRKR