EDN2_BOVIN
ID EDN2_BOVIN Reviewed; 177 AA.
AC Q867A9;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Endothelin-2;
DE Short=ET-2;
DE AltName: Full=Preproendothelin-2;
DE Short=PPET2;
DE Flags: Precursor;
GN Name=EDN2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=14756425; DOI=10.1080/10425170310001607787;
RA Uchide T., Fujimori Y., Temma K., Sasaki T., Saida K.;
RT "Cloning of bovine preproendothelin-2 cDNA and organ distribution of
RT transcripts.";
RL DNA Seq. 14:385-392(2003).
CC -!- FUNCTION: Endothelins are endothelium-derived vasoconstrictor peptides.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in various organs including heart, lung,
CC liver, kidney, gastrointestinal tract, uterus and ovary, but not in
CC spleen. Within the gastrointestinal tract, gene expression was detected
CC in rumen, a ruminant-specific digestive organ, as well as stomach,
CC duodenum and colon. {ECO:0000269|PubMed:14756425}.
CC -!- SIMILARITY: Belongs to the endothelin/sarafotoxin family.
CC {ECO:0000305}.
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DR EMBL; AB100737; BAC55924.1; -; mRNA.
DR RefSeq; NP_783645.1; NM_175714.2.
DR AlphaFoldDB; Q867A9; -.
DR STRING; 9913.ENSBTAP00000028571; -.
DR PaxDb; Q867A9; -.
DR PRIDE; Q867A9; -.
DR Ensembl; ENSBTAT00000028571; ENSBTAP00000028571; ENSBTAG00000021434.
DR GeneID; 319094; -.
DR KEGG; bta:319094; -.
DR CTD; 1907; -.
DR VEuPathDB; HostDB:ENSBTAG00000021434; -.
DR VGNC; VGNC:28328; EDN2.
DR eggNOG; ENOG502S5KM; Eukaryota.
DR GeneTree; ENSGT00950000183053; -.
DR HOGENOM; CLU_090013_2_1_1; -.
DR InParanoid; Q867A9; -.
DR OMA; PTAWCSV; -.
DR OrthoDB; 1264335at2759; -.
DR TreeFam; TF333184; -.
DR Reactome; R-BTA-375276; Peptide ligand-binding receptors.
DR Reactome; R-BTA-416476; G alpha (q) signalling events.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000021434; Expressed in anterior segment of eyeball and 46 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031708; F:endothelin B receptor binding; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0014824; P:artery smooth muscle contraction; IEA:Ensembl.
DR GO; GO:0048675; P:axon extension; IEA:Ensembl.
DR GO; GO:0019722; P:calcium-mediated signaling; IEA:Ensembl.
DR GO; GO:0009932; P:cell tip growth; IEA:Ensembl.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0043542; P:endothelial cell migration; IEA:Ensembl.
DR GO; GO:0097009; P:energy homeostasis; IEA:Ensembl.
DR GO; GO:0048016; P:inositol phosphate-mediated signaling; IEA:Ensembl.
DR GO; GO:0048286; P:lung alveolus development; IEA:Ensembl.
DR GO; GO:0042116; P:macrophage activation; IEA:Ensembl.
DR GO; GO:0048246; P:macrophage chemotaxis; IEA:Ensembl.
DR GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR GO; GO:0002690; P:positive regulation of leukocyte chemotaxis; IEA:Ensembl.
DR GO; GO:0060585; P:positive regulation of prostaglandin-endoperoxide synthase activity; IBA:GO_Central.
DR GO; GO:0045987; P:positive regulation of smooth muscle contraction; IEA:Ensembl.
DR GO; GO:0001516; P:prostaglandin biosynthetic process; IEA:Ensembl.
DR GO; GO:0003100; P:regulation of systemic arterial blood pressure by endothelin; IBA:GO_Central.
DR GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
DR GO; GO:0001659; P:temperature homeostasis; IEA:Ensembl.
DR GO; GO:0014826; P:vein smooth muscle contraction; IBA:GO_Central.
DR InterPro; IPR020475; Endothelin.
DR InterPro; IPR019764; Endothelin_toxin_CS.
DR InterPro; IPR001928; Endothln-like_toxin.
DR InterPro; IPR015658; ET-2.
DR PANTHER; PTHR13874; PTHR13874; 1.
DR PANTHER; PTHR13874:SF9; PTHR13874:SF9; 1.
DR Pfam; PF00322; Endothelin; 1.
DR PRINTS; PR00365; ENDOTHELIN.
DR SMART; SM00272; END; 2.
DR PROSITE; PS00270; ENDOTHELIN; 2.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Reference proteome;
KW Secreted; Signal; Vasoactive; Vasoconstrictor.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PROPEP 24..45
FT /evidence="ECO:0000250"
FT /id="PRO_0000008081"
FT PEPTIDE 48..68
FT /note="Endothelin-2"
FT /id="PRO_0000008082"
FT PROPEP 69..177
FT /evidence="ECO:0000250"
FT /id="PRO_0000008083"
FT REGION 95..110
FT /note="Endothelin-like"
FT REGION 155..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 68..69
FT /note="Cleavage; by KEL"
FT /evidence="ECO:0000250"
FT DISULFID 48..62
FT /evidence="ECO:0000250"
FT DISULFID 50..58
FT /evidence="ECO:0000250"
SQ SEQUENCE 177 AA; 19706 MW; 830BCAD401A2284F CRC64;
MPTALCSIAL ALLVALHEGK SQAATTPIPE QPAPLPRARG SHLRTRRCSC SSWLDKECVY
FCHLDIIWVN TPGQTAPYGL GNPPRRRRRS LPRRCECYSA RDPACATFCH QRPWTDAVAV
PGSGSPAAAF QDGKTQATAG ELLQRLRVIS ATKIHFARQQ QKPTRETRPT HSRQRKR
