ID   ADRC_PENRW              Reviewed;        1442 AA.
AC   B6HV31;
DT   10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=ABC-type transporter adrC {ECO:0000303|Ref.2};
DE   AltName: Full=Andrastin A biosynthesis cluster protein C {ECO:0000303|Ref.2};
GN   Name=adrC {ECO:0000303|Ref.2}; ORFNames=Pc22g22840;
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS   54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255;
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA   van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA   Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
RN   [2]
RP   IDENTIFICATION, AND FUNCTION.
RX   DOI=10.1016/j.tet.2013.07.029;
RA   Matsuda Y., Awakawa T., Abe I.;
RT   "Reconstituted biosynthesis of fungal meroterpenoid andrastin A.";
RL   Tetrahedron 69:8199-8204(2013).
CC   -!- FUNCTION: ABC-type transporter; part of the gene cluster that mediates
CC       the biosynthesis of the meroterpenoid compound andrastin A, a promising
CC       antitumoral compound (Ref.2). Is required for the production of
CC       andrastin A but does not have a significant role in its secretion (By
CC       similarity). {ECO:0000250|UniProtKB:A0A1Y0BRF0, ECO:0000269|Ref.2}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC       PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
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DR   EMBL; AM920437; CAP99572.1; -; Genomic_DNA.
DR   RefSeq; XP_002566178.1; XM_002566132.1.
DR   AlphaFoldDB; B6HV31; -.
DR   SMR; B6HV31; -.
DR   EnsemblFungi; CAP99572; CAP99572; PCH_Pc22g22840.
DR   GeneID; 8309010; -.
DR   KEGG; pcs:Pc22g22840; -.
DR   VEuPathDB; FungiDB:PCH_Pc22g22840; -.
DR   eggNOG; KOG0065; Eukaryota.
DR   HOGENOM; CLU_000604_35_0_1; -.
DR   OMA; MIKHHRG; -.
DR   OrthoDB; 1022017at2759; -.
DR   BioCyc; PCHR:PC22G22840-MON; -.
DR   Proteomes; UP000000724; Contig Pc00c22.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   CDD; cd03232; ABCG_PDR_domain2; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR013525; ABC_2_trans.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR043926; ABCG_dom.
DR   InterPro; IPR034003; ABCG_PDR_2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010929; PDR_CDR_ABC.
DR   Pfam; PF01061; ABC2_membrane; 2.
DR   Pfam; PF19055; ABC2_membrane_7; 1.
DR   Pfam; PF00005; ABC_tran; 2.
DR   Pfam; PF06422; PDR_CDR; 1.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..1442
FT                   /note="ABC-type transporter adrC"
FT                   /id="PRO_0000446490"
FT   TRANSMEM        476..496
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        513..533
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        558..578
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        587..607
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        620..640
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        727..747
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1139..1159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1171..1191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1212..1232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1254..1274
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1280..1300
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1405..1425
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          120..367
FT                   /note="ABC transporter 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   DOMAIN          803..1045
FT                   /note="ABC transporter 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          768..797
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         839..846
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   1442 AA;  161327 MW;  D03988BF60A9C5AD CRC64;
     MAPDEGDQAM SLQEEKPAYP SLSTTSSAEL LHGAPLNDNE RLDILQTAEH AMHRGSPKVD
     PHIWTNVTSH FSDSSTIDGR QRDILFERLT VRGKGSPFQI QQTILSALLY PLAYPIKRLV
     KLVGKKESHD GPGTILRGLN GIVCSGELLL VLGRPGSGCS TFLKSLCGYL EGLDVDTASE
     IQYKGVPFTT MMEKYRGDVV YNQEANHHFP NLTVGQTLEF AAHARAPHNR AGNQRGDQCQ
     WRGKKESQVS LALFSLGGER TEGKAMRTDT VGMNSIAETV LSRASIVAWD NSTRGLDAAT
     AVDFVRALRT SAKLSGSCHA LAVYQASETL YNTFDQLILL YEGREIYFGS RERAVPYFES
     MGWKRPPQQV SADFLTAITN PGERQPQVGM EHAVPRTSLE FEAYWKSSPE HAELQRSMQQ
     YKQKTPLDIS EEIKLDEVKR LEQSTHARPS SPYLLSVPMQ IRLCIVRAWQ RTRNDIPGLV
     SSAVAQIVVS LIIGSLFYNI PQTTAGLGQR GSVLFLAVLT NALISLLEIN TLYSQRLIVE
     KQAAYAFVRP FTEAIAGVIV DFPVKLFRCA LSAIIIYFLA NLRREASHFF IYILFQLTAV
     MTMATMFRTL ATVTRTIGQA MSLAGVIIIC VAVYTGFTVP QFDMPPWFAW IRWVNPIFYA
     FEAIVANEFH GRHFECVEYI PSLSFQEGLS FTCSYVGSVP GERYVSGDAY IAGSYDYSYD
     HVWRNYGILV AFLVFFYVLY FWLTELIPGT TPTHEVLIFR RGDAHPKLSR SDLESGEQPR
     PLQELKSLAP PAHPSMAEQK DTLSWNGVCY DIPVKGGEKR LLDDVSGWVK PGSLTALMGV
     SGAGKTTLMN VLARRMTIGV VTGDMLVNGH EPDASFSRKT GYVQQQDLHV ETCTIREALR
     FSAALRQPQS VSTEEKYKFV EEVIQLLGME DFAEAVIGNP GDGLNTEQRK LLSIGVELAA
     NPQLLIFLDE PTSGLDSRSS WAICKFMRKL ADNGQPVLAT IHQPSAVLFE QFDRLLFLAK
     GGKTVYFGDV GHQARTVLEY LEKNGARQCG PTENPAEYML EVIGGGTQGQ STPIDWVHAW
     KNSSENTQVL EELDSLVSSP SNAIPADPCK LSEFAMPLAV QFHHVMKRDL QQYYRQPEYI
     LAKFGAGIFC GLFIGFSFWS SDNSSQGFQN VLFSLFLLCT IFSTLVNQIM PKFLSRRALY
     ELRERPAKTY SWTVFILCQI LVELPWQTLL GICTWASFYF SVYGDDQSPQ RQVLILLFTV
     QFFLFASTFA QFVIAAVPNL VLGSMMATFT FLLCLLFNGI MQPPSALPRF WIFMNRVSPL
     TYYVGGISAT ALHGRPIHCS NRELRVFDPP QGQTCGQYLA EYLKTAQGTL HNPLSSDRCQ
     YCPLRVADQY LAARDISWHD RWRNFGVFSV YIIFNIIGAI GLYYLVRVLP YAMKNRTQKS
     PT