ID   EDN2_FELCA              Reviewed;         178 AA.
AC   Q5NRQ0;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Endothelin-2;
DE            Short=ET-2;
DE   AltName: Full=Preproendothelin-2;
DE            Short=PPET2;
DE   Flags: Precursor;
GN   Name=EDN2;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Uchide T.;
RT   "Cloning of cat preproendothelin-2 cDNA.";
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Endothelins are endothelium-derived vasoconstrictor peptides.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the endothelin/sarafotoxin family.
CC       {ECO:0000305}.
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DR   EMBL; AB197699; BAD83371.1; -; mRNA.
DR   RefSeq; NP_001009387.1; NM_001009387.1.
DR   AlphaFoldDB; Q5NRQ0; -.
DR   STRING; 9685.ENSFCAP00000013015; -.
DR   GeneID; 494215; -.
DR   KEGG; fca:494215; -.
DR   CTD; 1907; -.
DR   eggNOG; ENOG502S5KM; Eukaryota.
DR   HOGENOM; CLU_090013_2_1_1; -.
DR   InParanoid; Q5NRQ0; -.
DR   OMA; PTAWCSV; -.
DR   OrthoDB; 1264335at2759; -.
DR   TreeFam; TF333184; -.
DR   Proteomes; UP000011712; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031708; F:endothelin B receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central.
DR   GO; GO:0060585; P:positive regulation of prostaglandin-endoperoxide synthase activity; IBA:GO_Central.
DR   GO; GO:0003100; P:regulation of systemic arterial blood pressure by endothelin; IBA:GO_Central.
DR   GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
DR   GO; GO:0014826; P:vein smooth muscle contraction; IBA:GO_Central.
DR   InterPro; IPR020475; Endothelin.
DR   InterPro; IPR019764; Endothelin_toxin_CS.
DR   InterPro; IPR001928; Endothln-like_toxin.
DR   InterPro; IPR015658; ET-2.
DR   PANTHER; PTHR13874; PTHR13874; 1.
DR   PANTHER; PTHR13874:SF9; PTHR13874:SF9; 1.
DR   Pfam; PF00322; Endothelin; 1.
DR   PRINTS; PR00365; ENDOTHELIN.
DR   SMART; SM00272; END; 2.
DR   PROSITE; PS00270; ENDOTHELIN; 2.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Reference proteome;
KW   Secreted; Signal; Vasoactive; Vasoconstrictor.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   PROPEP          27..46
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000008090"
FT   PEPTIDE         49..69
FT                   /note="Endothelin-2"
FT                   /id="PRO_0000008091"
FT   PROPEP          70..178
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000008092"
FT   REGION          96..111
FT                   /note="Endothelin-like"
FT   SITE            69..70
FT                   /note="Cleavage; by KEL"
FT                   /evidence="ECO:0000250"
FT   DISULFID        49..63
FT                   /evidence="ECO:0000250"
FT   DISULFID        51..59
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   178 AA;  19797 MW;  821CB24EFEF3558F CRC64;
     MVAMPTAWCS IALALLLALH EGKGQVAAAP DQPAPSHRAR ASHLRPRRCS CSSWLDKECV
     YFCHLDIIWV NTPGQTAPYG LGNPPRRRRR SLPKRCECSS GRDPACATFC HRRPKPEAVV
     VPGSGPPPDV FQAGRARPSA GELLQQLRDI SAAKSHFARR QQVAVRELRP THSRRWKR