EDN2_MOUSE
ID EDN2_MOUSE Reviewed; 175 AA.
AC P22389; Q9JME3;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 27-APR-2001, sequence version 3.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=Endothelin-2;
DE Short=ET-2;
DE AltName: Full=Preproendothelin-2;
DE Short=PPET2;
DE AltName: Full=Vasoactive intestinal contractor;
DE Short=VIC;
DE Flags: Precursor;
GN Name=Edn2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=ICR;
RX PubMed=1859843; DOI=10.1016/0167-4781(91)90186-p;
RA Saida K., Mitsui Y.;
RT "cDNA cloning, sequence analysis and tissue distribution of a precursor for
RT vasoactive intestinal contractor (VIC).";
RL Biochim. Biophys. Acta 1089:404-406(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10708518; DOI=10.1006/geno.1999.6083;
RA Saida K., Hashimoto M., Mitsui Y., Ishida N., Uchide T.;
RT "The prepro vasoactive intestinal contractor (VIC)/endothelin-2 gene
RT (EDN2): structure, evolution, production, and embryonic expression.";
RL Genomics 64:51-61(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Retina;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-70.
RX PubMed=2768235; DOI=10.1016/s0021-9258(18)63739-1;
RA Saida K., Mitsui Y., Ishida N.;
RT "A novel peptide, vasoactive intestinal contractor, of a new (endothelin)
RT peptide family. Molecular cloning, expression, and biological activity.";
RL J. Biol. Chem. 264:14613-14616(1989).
CC -!- FUNCTION: Vasoconstrictor.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the endothelin/sarafotoxin family.
CC {ECO:0000305}.
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DR EMBL; X59556; CAA42155.1; -; mRNA.
DR EMBL; AB030303; BAA94208.1; -; Genomic_DNA.
DR EMBL; BC037042; AAH37042.1; -; mRNA.
DR EMBL; M26498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS38864.1; -.
DR PIR; S17194; S17194.
DR RefSeq; NP_031928.2; NM_007902.3.
DR AlphaFoldDB; P22389; -.
DR STRING; 10090.ENSMUSP00000030384; -.
DR PhosphoSitePlus; P22389; -.
DR PaxDb; P22389; -.
DR PRIDE; P22389; -.
DR ProteomicsDB; 275438; -.
DR Antibodypedia; 32186; 187 antibodies from 26 providers.
DR DNASU; 13615; -.
DR Ensembl; ENSMUST00000030384; ENSMUSP00000030384; ENSMUSG00000028635.
DR GeneID; 13615; -.
DR KEGG; mmu:13615; -.
DR UCSC; uc008unb.1; mouse.
DR CTD; 1907; -.
DR MGI; MGI:95284; Edn2.
DR VEuPathDB; HostDB:ENSMUSG00000028635; -.
DR eggNOG; ENOG502S5KM; Eukaryota.
DR GeneTree; ENSGT00950000183053; -.
DR HOGENOM; CLU_090013_2_1_1; -.
DR InParanoid; P22389; -.
DR OMA; PTAWCSV; -.
DR OrthoDB; 1264335at2759; -.
DR PhylomeDB; P22389; -.
DR TreeFam; TF333184; -.
DR Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR BioGRID-ORCS; 13615; 2 hits in 72 CRISPR screens.
DR PRO; PR:P22389; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; P22389; protein.
DR Bgee; ENSMUSG00000028635; Expressed in decidua and 41 other tissues.
DR Genevisible; P22389; MM.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0031708; F:endothelin B receptor binding; ISO:MGI.
DR GO; GO:0005179; F:hormone activity; ISO:MGI.
DR GO; GO:0001525; P:angiogenesis; IDA:MGI.
DR GO; GO:0014824; P:artery smooth muscle contraction; ISO:MGI.
DR GO; GO:0048675; P:axon extension; IDA:MGI.
DR GO; GO:0019722; P:calcium-mediated signaling; ISO:MGI.
DR GO; GO:0009932; P:cell tip growth; IDA:MGI.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; ISO:MGI.
DR GO; GO:0043542; P:endothelial cell migration; IDA:MGI.
DR GO; GO:0097009; P:energy homeostasis; IMP:MGI.
DR GO; GO:0048016; P:inositol phosphate-mediated signaling; ISO:MGI.
DR GO; GO:0048286; P:lung alveolus development; IMP:MGI.
DR GO; GO:0042116; P:macrophage activation; ISO:MGI.
DR GO; GO:0048246; P:macrophage chemotaxis; ISO:MGI.
DR GO; GO:0046888; P:negative regulation of hormone secretion; ISO:MGI.
DR GO; GO:0031175; P:neuron projection development; IDA:MGI.
DR GO; GO:0030593; P:neutrophil chemotaxis; ISO:MGI.
DR GO; GO:0001543; P:ovarian follicle rupture; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI.
DR GO; GO:0010460; P:positive regulation of heart rate; ISO:MGI.
DR GO; GO:0046887; P:positive regulation of hormone secretion; ISO:MGI.
DR GO; GO:0002690; P:positive regulation of leukocyte chemotaxis; ISO:MGI.
DR GO; GO:0060585; P:positive regulation of prostaglandin-endoperoxide synthase activity; IMP:BHF-UCL.
DR GO; GO:0045987; P:positive regulation of smooth muscle contraction; IDA:MGI.
DR GO; GO:0001516; P:prostaglandin biosynthetic process; IDA:BHF-UCL.
DR GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; ISO:MGI.
DR GO; GO:0003100; P:regulation of systemic arterial blood pressure by endothelin; ISO:MGI.
DR GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
DR GO; GO:0006939; P:smooth muscle contraction; IDA:MGI.
DR GO; GO:0001659; P:temperature homeostasis; IMP:MGI.
DR GO; GO:0001944; P:vasculature development; IDA:MGI.
DR GO; GO:0042310; P:vasoconstriction; ISO:MGI.
DR GO; GO:0014826; P:vein smooth muscle contraction; ISO:MGI.
DR InterPro; IPR020475; Endothelin.
DR InterPro; IPR019764; Endothelin_toxin_CS.
DR InterPro; IPR001928; Endothln-like_toxin.
DR InterPro; IPR015658; ET-2.
DR PANTHER; PTHR13874; PTHR13874; 1.
DR PANTHER; PTHR13874:SF9; PTHR13874:SF9; 1.
DR Pfam; PF00322; Endothelin; 1.
DR PRINTS; PR00365; ENDOTHELIN.
DR SMART; SM00272; END; 2.
DR PROSITE; PS00270; ENDOTHELIN; 2.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Reference proteome;
KW Secreted; Signal; Vasoactive; Vasoconstrictor.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..43
FT /id="PRO_0000008099"
FT PEPTIDE 46..66
FT /note="Endothelin-2"
FT /id="PRO_0000008100"
FT PROPEP 67..175
FT /id="PRO_0000008101"
FT REGION 93..108
FT /note="Endothelin-like"
FT SITE 66..67
FT /note="Cleavage; by KEL"
FT /evidence="ECO:0000250"
FT DISULFID 46..60
FT /evidence="ECO:0000250"
FT DISULFID 48..56
FT /evidence="ECO:0000250"
FT CONFLICT 151..152
FT /note="KL -> NV (in Ref. 1; CAA42155)"
FT /evidence="ECO:0000305"
FT CONFLICT 156..175
FT /note="RLQPEVTRKAIPAYSRWRKR -> SYSQR (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 175 AA; 19538 MW; 6BCDD79CAAA0244A CRC64;
MVSAWCSIAL ALLLALHEGK GQAAATLEQP ASAPKGRGPH LRFRRCSCNS WLDKECVYFC
HLDIIWVNTA GQTAPYGLGN PPRRRRRSLP KRCECSTAGD SACATFCHRR HWPEAVVAPS
SQAPAAVLKT GKMWTAEGDL LRKLRDISAT KLRFARLQPE VTRKAIPAYS RWRKR
