EDN2_RAT
ID EDN2_RAT Reviewed; 176 AA.
AC P23943;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Endothelin-2;
DE Short=ET-2;
DE AltName: Full=Preproendothelin-2;
DE Short=PPET2;
DE AltName: Full=Vasoactive intestinal contractor;
DE Short=VIC;
DE Flags: Precursor;
GN Name=Edn2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9060420; DOI=10.1007/s003359900624;
RA Deng A.Y.;
RT "Structure and organization of the rat endothelin-2 gene.";
RL Mamm. Genome 8:157-157(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 21-71.
RX PubMed=1840558; DOI=10.1016/0888-7543(91)90505-9;
RA Bloch K.D., Hong C.C., Eddy R.L. Jr., Shows T.B., Quertermous T.;
RT "cDNA cloning and chromosomal assignment of the endothelin 2 gene:
RT vasoactive intestinal contractor peptide is rat endothelin 2.";
RL Genomics 10:236-242(1991).
CC -!- FUNCTION: Vasoconstrictor.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the endothelin/sarafotoxin family.
CC {ECO:0000305}.
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DR EMBL; U64949; AAB39213.1; -; Genomic_DNA.
DR EMBL; U59510; AAB39213.1; JOINED; Genomic_DNA.
DR EMBL; U64946; AAB39213.1; JOINED; Genomic_DNA.
DR EMBL; U64947; AAB39213.1; JOINED; Genomic_DNA.
DR EMBL; U64948; AAB39213.1; JOINED; Genomic_DNA.
DR EMBL; M65200; AAA42338.1; -; Genomic_DNA.
DR PIR; B39070; B39070.
DR AlphaFoldDB; P23943; -.
DR STRING; 10116.ENSRNOP00000012569; -.
DR PaxDb; P23943; -.
DR PRIDE; P23943; -.
DR UCSC; RGD:2533; rat.
DR RGD; 2533; Edn2.
DR eggNOG; ENOG502S5KM; Eukaryota.
DR InParanoid; P23943; -.
DR PhylomeDB; P23943; -.
DR Reactome; R-RNO-375276; Peptide ligand-binding receptors.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR PRO; PR:P23943; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0031708; F:endothelin B receptor binding; ISO:RGD.
DR GO; GO:0005179; F:hormone activity; ISO:RGD.
DR GO; GO:0001525; P:angiogenesis; ISO:RGD.
DR GO; GO:0014824; P:artery smooth muscle contraction; ISO:RGD.
DR GO; GO:0048675; P:axon extension; ISO:RGD.
DR GO; GO:0019722; P:calcium-mediated signaling; ISO:RGD.
DR GO; GO:0009932; P:cell tip growth; ISO:RGD.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; ISO:RGD.
DR GO; GO:0043542; P:endothelial cell migration; ISO:RGD.
DR GO; GO:0097009; P:energy homeostasis; ISO:RGD.
DR GO; GO:0048016; P:inositol phosphate-mediated signaling; ISO:RGD.
DR GO; GO:0048286; P:lung alveolus development; ISO:RGD.
DR GO; GO:0042116; P:macrophage activation; ISO:RGD.
DR GO; GO:0048246; P:macrophage chemotaxis; ISO:RGD.
DR GO; GO:0046888; P:negative regulation of hormone secretion; IDA:RGD.
DR GO; GO:0031175; P:neuron projection development; ISO:RGD.
DR GO; GO:0030593; P:neutrophil chemotaxis; ISO:RGD.
DR GO; GO:0001543; P:ovarian follicle rupture; IDA:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:RGD.
DR GO; GO:0010460; P:positive regulation of heart rate; ISO:RGD.
DR GO; GO:0046887; P:positive regulation of hormone secretion; IDA:RGD.
DR GO; GO:0002690; P:positive regulation of leukocyte chemotaxis; ISO:RGD.
DR GO; GO:0060585; P:positive regulation of prostaglandin-endoperoxide synthase activity; ISO:RGD.
DR GO; GO:0045987; P:positive regulation of smooth muscle contraction; IDA:RGD.
DR GO; GO:0001516; P:prostaglandin biosynthetic process; ISO:RGD.
DR GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; IMP:RGD.
DR GO; GO:0003100; P:regulation of systemic arterial blood pressure by endothelin; ISO:RGD.
DR GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
DR GO; GO:0001659; P:temperature homeostasis; ISO:RGD.
DR GO; GO:0001944; P:vasculature development; ISO:RGD.
DR GO; GO:0042310; P:vasoconstriction; ISO:RGD.
DR GO; GO:0014826; P:vein smooth muscle contraction; ISO:RGD.
DR InterPro; IPR020475; Endothelin.
DR InterPro; IPR019764; Endothelin_toxin_CS.
DR InterPro; IPR001928; Endothln-like_toxin.
DR InterPro; IPR015658; ET-2.
DR PANTHER; PTHR13874; PTHR13874; 1.
DR PANTHER; PTHR13874:SF9; PTHR13874:SF9; 1.
DR Pfam; PF00322; Endothelin; 1.
DR PRINTS; PR00365; ENDOTHELIN.
DR SMART; SM00272; END; 2.
DR PROSITE; PS00270; ENDOTHELIN; 2.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Reference proteome;
KW Secreted; Signal; Vasoactive; Vasoconstrictor.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..44
FT /id="PRO_0000008105"
FT PEPTIDE 47..67
FT /note="Endothelin-2"
FT /id="PRO_0000008106"
FT PROPEP 68..176
FT /id="PRO_0000008107"
FT REGION 94..109
FT /note="Endothelin-like"
FT SITE 67..68
FT /note="Cleavage; by KEL"
FT /evidence="ECO:0000250"
FT DISULFID 47..61
FT /evidence="ECO:0000250"
FT DISULFID 49..57
FT /evidence="ECO:0000250"
SQ SEQUENCE 176 AA; 19478 MW; 9CAE30134EB1E73F CRC64;
MVSPAWCSIA LALLLALHEG KGQAAATMEQ PASAPKGRGP HLRFRRCSCN SWLDKECVYF
CHLDIIWVNT AGQTAPYGLG NPPQRRRRSL PKRCECSSAG DSACATFCHR RPWPEAEVTS
SSQGPAAVLE TSKTWTAAGD LLQKLRDISA AKLQFVRLRP ELTREAIPAH SRRRKR
