ID   EDN3_CANLF              Reviewed;         198 AA.
AC   Q765Z4;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Endothelin-3;
DE            Short=ET-3;
DE   AltName: Full=Preproendothelin-3;
DE            Short=PPET3;
DE   Flags: Precursor;
GN   Name=EDN3;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Lung;
RX   PubMed=15528858; DOI=10.1292/jvms.66.1251;
RA   Fujimori Y., Uchide T., Temma K., Sasaki T., Kizaki K., Hara Y., Saida K.;
RT   "Complete cDNA sequence and mRNA expression of dog preproendothelin-3.";
RL   J. Vet. Med. Sci. 66:1251-1254(2004).
CC   -!- FUNCTION: Endothelins are endothelium-derived vasoconstrictor peptides.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in which included heart, lung, liver,
CC       kidney, spleen, stomach, pancreas, duodenum, colon, uterus, ovary and
CC       testis. {ECO:0000269|PubMed:15528858}.
CC   -!- SIMILARITY: Belongs to the endothelin/sarafotoxin family.
CC       {ECO:0000305}.
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DR   EMBL; AB115086; BAD07479.1; -; mRNA.
DR   RefSeq; NP_001002942.1; NM_001002942.1.
DR   AlphaFoldDB; Q765Z4; -.
DR   STRING; 9612.ENSCAFP00000018044; -.
DR   PaxDb; Q765Z4; -.
DR   GeneID; 403406; -.
DR   KEGG; cfa:403406; -.
DR   CTD; 1908; -.
DR   eggNOG; ENOG502S4W0; Eukaryota.
DR   InParanoid; Q765Z4; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031708; F:endothelin B receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central.
DR   GO; GO:0060585; P:positive regulation of prostaglandin-endoperoxide synthase activity; IBA:GO_Central.
DR   GO; GO:0003100; P:regulation of systemic arterial blood pressure by endothelin; IBA:GO_Central.
DR   GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
DR   GO; GO:0014826; P:vein smooth muscle contraction; IBA:GO_Central.
DR   InterPro; IPR020475; Endothelin.
DR   InterPro; IPR019764; Endothelin_toxin_CS.
DR   InterPro; IPR001928; Endothln-like_toxin.
DR   PANTHER; PTHR13874; PTHR13874; 1.
DR   Pfam; PF00322; Endothelin; 1.
DR   PRINTS; PR00365; ENDOTHELIN.
DR   SMART; SM00272; END; 2.
DR   PROSITE; PS00270; ENDOTHELIN; 2.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Reference proteome;
KW   Secreted; Signal; Vasoactive; Vasoconstrictor.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   PROPEP          17..86
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000008108"
FT   PEPTIDE         89..109
FT                   /note="Endothelin-3"
FT                   /id="PRO_0000008109"
FT   PROPEP          110..198
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000008110"
FT   REGION          22..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          150..164
FT                   /note="Endothelin-like"
FT   REGION          174..198
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            109..110
FT                   /note="Cleavage; by KEL"
FT                   /evidence="ECO:0000250"
FT   DISULFID        89..103
FT                   /evidence="ECO:0000250"
FT   DISULFID        91..99
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   198 AA;  21527 MW;  BF60D73286A73B7A CRC64;
     MEPGLWLLFG LTVTSAAGLV PCPQPGDAGK SGVPGTPPTA RSEGDIQEPV AMTAVQGPSP
     RSPEQEQELG RFGEQASKGG PVHGRARRCT CFTYKDKECV YYCHLDIIWI NTPEQTVPYG
     LSNYRGSFRG RRSTGLFPQS PQPSKWTQRC ACVQSQDSAC LHFCTRTLAV SRNSRTATNP
     DKEEEPASRG NGGLRPTR