ID   EDN3_PIG                Reviewed;         204 AA.
AC   A5A752;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Endothelin-3;
DE            Short=ET-3;
DE   AltName: Full=Preproendothelin-3;
DE            Short=PPET3;
DE   Flags: Precursor;
GN   Name=EDN3;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Okumura N., Matsumoto T., Hamasima N., Uenishi H., Ogawa T., Komatsuda A.,
RA   Fukudome N., Ide H., Suzuki A., Kojima C., Awata T.;
RT   "Sequences and genetic variations of forty-four porcine coat color related
RT   genes.";
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Porcine genome sequencing project;
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Endothelins are endothelium-derived vasoconstrictor peptides.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the endothelin/sarafotoxin family.
CC       {ECO:0000305}.
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DR   EMBL; AB271922; BAF62297.1; -; mRNA.
DR   EMBL; CR956624; CAN13224.1; -; Genomic_DNA.
DR   RefSeq; NP_001092052.1; NM_001098582.2.
DR   AlphaFoldDB; A5A752; -.
DR   BMRB; A5A752; -.
DR   STRING; 9823.ENSSSCP00000008036; -.
DR   PaxDb; A5A752; -.
DR   PRIDE; A5A752; -.
DR   Ensembl; ENSSSCT00000008255; ENSSSCP00000008036; ENSSSCG00000007527.
DR   Ensembl; ENSSSCT00015002548; ENSSSCP00015000818; ENSSSCG00015002079.
DR   Ensembl; ENSSSCT00045042513; ENSSSCP00045029524; ENSSSCG00045024871.
DR   Ensembl; ENSSSCT00055027748; ENSSSCP00055022095; ENSSSCG00055014030.
DR   GeneID; 100049663; -.
DR   KEGG; ssc:100049663; -.
DR   CTD; 1908; -.
DR   VGNC; VGNC:96260; EDN3.
DR   eggNOG; ENOG502S4W0; Eukaryota.
DR   GeneTree; ENSGT00950000183053; -.
DR   HOGENOM; CLU_090013_0_0_1; -.
DR   InParanoid; A5A752; -.
DR   OMA; QPSKWTL; -.
DR   OrthoDB; 1264335at2759; -.
DR   TreeFam; TF333184; -.
DR   Reactome; R-SSC-375276; Peptide ligand-binding receptors.
DR   Reactome; R-SSC-416476; G alpha (q) signalling events.
DR   Proteomes; UP000008227; Chromosome 17.
DR   Proteomes; UP000314985; Unplaced.
DR   Bgee; ENSSSCG00000007527; Expressed in hindlimb bud and 23 other tissues.
DR   ExpressionAtlas; A5A752; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031708; F:endothelin B receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central.
DR   GO; GO:0060585; P:positive regulation of prostaglandin-endoperoxide synthase activity; IBA:GO_Central.
DR   GO; GO:0003100; P:regulation of systemic arterial blood pressure by endothelin; IBA:GO_Central.
DR   GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
DR   GO; GO:0014826; P:vein smooth muscle contraction; IBA:GO_Central.
DR   InterPro; IPR020475; Endothelin.
DR   InterPro; IPR019764; Endothelin_toxin_CS.
DR   InterPro; IPR001928; Endothln-like_toxin.
DR   PANTHER; PTHR13874; PTHR13874; 1.
DR   Pfam; PF00322; Endothelin; 1.
DR   PRINTS; PR00365; ENDOTHELIN.
DR   SMART; SM00272; END; 2.
DR   PROSITE; PS00270; ENDOTHELIN; 2.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Reference proteome;
KW   Secreted; Signal; Vasoactive; Vasoconstrictor.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   PROPEP          18..80
FT                   /id="PRO_0000296393"
FT   PEPTIDE         83..103
FT                   /note="Endothelin-3"
FT                   /id="PRO_0000296394"
FT   PROPEP          104..204
FT                   /id="PRO_0000296395"
FT   REGION          18..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          115..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          144..158
FT                   /note="Endothelin-like"
FT   REGION          166..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            103..104
FT                   /note="Cleavage; by KEL"
FT                   /evidence="ECO:0000250"
FT   DISULFID        83..97
FT                   /evidence="ECO:0000250"
FT   DISULFID        85..93
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   204 AA;  22190 MW;  B66A33C4E19C7662 CRC64;
     MELRLWFLFG LTVTSAAGPV PRPQPGDAGR SGVPRAPSAT KETMAMVATR GPSPRSSGQE
     QEPGPFGELA AKGGPVRYRA RRCTCFTYKD KECVYYCHLD IIWINTPERT VPYGLSNHRG
     SVRGRRSAGP SPQSSQPSRG TLRCACAESQ DRACVYFCTR TLAARGASRT PETPDKEAGK
     PAGRATGGLH PRRLKSRTDK ARRL