ID   EDN3_RABIT              Reviewed;         114 AA.
AC   P19998;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Endothelin-3;
DE            Short=ET-3;
DE   AltName: Full=Preproendothelin-3;
DE            Short=PPET3;
DE   Flags: Precursor; Fragment;
GN   Name=EDN3;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2183185; DOI=10.1093/nar/18.2.374;
RA   Ohkubo S., Itoh Y., Kimura C., Onda H., Fujino M.;
RT   "Nucleotide sequence of a rabbit genomic DNA encoding mature endothelin-
RT   3.";
RL   Nucleic Acids Res. 18:374-374(1990).
CC   -!- FUNCTION: Endothelins are endothelium-derived vasoconstrictor peptides.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the endothelin/sarafotoxin family.
CC       {ECO:0000305}.
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DR   EMBL; X15724; CAB59224.1; -; Genomic_DNA.
DR   PIR; S07898; S07898.
DR   AlphaFoldDB; P19998; -.
DR   BMRB; P19998; -.
DR   STRING; 9986.ENSOCUP00000019653; -.
DR   eggNOG; ENOG502S4W0; Eukaryota.
DR   InParanoid; P19998; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
DR   GO; GO:0042310; P:vasoconstriction; IEA:UniProtKB-KW.
DR   InterPro; IPR020475; Endothelin.
DR   InterPro; IPR019764; Endothelin_toxin_CS.
DR   InterPro; IPR001928; Endothln-like_toxin.
DR   PANTHER; PTHR13874; PTHR13874; 1.
DR   Pfam; PF00322; Endothelin; 1.
DR   PRINTS; PR00365; ENDOTHELIN.
DR   SMART; SM00272; END; 1.
DR   PROSITE; PS00270; ENDOTHELIN; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Reference proteome;
KW   Secreted; Signal; Vasoactive; Vasoconstrictor.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   PROPEP          18..86
FT                   /id="PRO_0000008117"
FT   PEPTIDE         89..109
FT                   /note="Endothelin-3"
FT                   /id="PRO_0000008118"
FT   PROPEP          110..>114
FT                   /id="PRO_0000008119"
FT   REGION          24..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            109..110
FT                   /note="Cleavage; by KEL"
FT                   /evidence="ECO:0000250"
FT   DISULFID        89..103
FT                   /evidence="ECO:0000250"
FT   DISULFID        91..99
FT                   /evidence="ECO:0000250"
FT   NON_TER         114
SQ   SEQUENCE   114 AA;  12041 MW;  5E515B3478AF67F8 CRC64;
     MEPGLWILLG LTVTAAAGFV PCPQTGGAGR TSVPRAPRVA GSEGDCEDSV ASPRRQTVAP
     TAGKGPSPGS PGRGQAAEGD PGHRRVRRCT CFTYKDKECV YYCHLDIIWI NTPE