EDNRA_MOUSE
ID EDNRA_MOUSE Reviewed; 427 AA.
AC Q61614; O54993; Q91VV2;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2003, sequence version 3.
DT 03-AUG-2022, entry version 178.
DE RecName: Full=Endothelin-1 receptor {ECO:0000305};
DE AltName: Full=Endothelin receptor type A {ECO:0000312|MGI:MGI:105923};
DE Short=ET-A;
DE Short=ET-AR;
DE Flags: Precursor;
GN Name=Ednra {ECO:0000312|MGI:MGI:105923}; Synonyms=Gpcr10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 99-368.
RC STRAIN=C57BL/6J; TISSUE=Lung;
RA Schoenfeld J.R., Lowe D.G.;
RL Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 198-314.
RC TISSUE=Testis;
RX PubMed=8288218; DOI=10.1006/geno.1993.1452;
RA Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I.,
RA Copeland N.G., Jenkins N.A.;
RT "Identification, chromosomal location, and genome organization of mammalian
RT G-protein-coupled receptors.";
RL Genomics 18:175-184(1993).
CC -!- FUNCTION: Receptor for endothelin-1. Mediates its action by association
CC with G proteins that activate a phosphatidylinositol-calcium second
CC messenger system. The rank order of binding affinities for ET-A is: ET1
CC > ET2 >> ET3 (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with HDAC7 and KAT5. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Endothelin receptor subfamily. EDNRA sub-subfamily.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AK043210; BAC31493.1; -; mRNA.
DR EMBL; BC008277; AAH08277.1; -; mRNA.
DR EMBL; AF039892; AAB96671.1; -; mRNA.
DR EMBL; L20340; AAA16845.1; -; mRNA.
DR CCDS; CCDS22427.1; -.
DR PIR; B57508; B57508.
DR RefSeq; NP_034462.1; NM_010332.2.
DR AlphaFoldDB; Q61614; -.
DR SMR; Q61614; -.
DR BioGRID; 199380; 2.
DR STRING; 10090.ENSMUSP00000034029; -.
DR BindingDB; Q61614; -.
DR ChEMBL; CHEMBL2286; -.
DR GlyGen; Q61614; 3 sites.
DR iPTMnet; Q61614; -.
DR PhosphoSitePlus; Q61614; -.
DR MaxQB; Q61614; -.
DR PaxDb; Q61614; -.
DR PRIDE; Q61614; -.
DR ProteomicsDB; 277797; -.
DR Antibodypedia; 2942; 356 antibodies from 34 providers.
DR DNASU; 13617; -.
DR Ensembl; ENSMUST00000034029; ENSMUSP00000034029; ENSMUSG00000031616.
DR GeneID; 13617; -.
DR KEGG; mmu:13617; -.
DR UCSC; uc009mhv.1; mouse.
DR CTD; 1909; -.
DR MGI; MGI:105923; Ednra.
DR VEuPathDB; HostDB:ENSMUSG00000031616; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244862; -.
DR HOGENOM; CLU_009579_28_0_1; -.
DR InParanoid; Q61614; -.
DR OMA; QFLCKFL; -.
DR OrthoDB; 876925at2759; -.
DR PhylomeDB; Q61614; -.
DR TreeFam; TF331292; -.
DR Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR BioGRID-ORCS; 13617; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Ednra; mouse.
DR PRO; PR:Q61614; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q61614; protein.
DR Bgee; ENSMUSG00000031616; Expressed in undifferentiated genital tubercle and 214 other tissues.
DR Genevisible; Q61614; MM.
DR GO; GO:0071944; C:cell periphery; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; ISO:MGI.
DR GO; GO:0045121; C:membrane raft; ISO:MGI.
DR GO; GO:0031965; C:nuclear membrane; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030315; C:T-tubule; ISO:MGI.
DR GO; GO:0004962; F:endothelin receptor activity; IMP:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; TAS:MGI.
DR GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; IGI:MGI.
DR GO; GO:0001525; P:angiogenesis; IGI:MGI.
DR GO; GO:0035904; P:aorta development; IMP:MGI.
DR GO; GO:0014824; P:artery smooth muscle contraction; ISO:MGI.
DR GO; GO:0003228; P:atrial cardiac muscle tissue development; IMP:MGI.
DR GO; GO:0048675; P:axon extension; IMP:MGI.
DR GO; GO:0007411; P:axon guidance; IMP:MGI.
DR GO; GO:0060385; P:axonogenesis involved in innervation; IMP:MGI.
DR GO; GO:0001974; P:blood vessel remodeling; IMP:MGI.
DR GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IMP:MGI.
DR GO; GO:0070588; P:calcium ion transmembrane transport; IDA:MGI.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IGI:MGI.
DR GO; GO:0003207; P:cardiac chamber formation; IMP:MGI.
DR GO; GO:0003253; P:cardiac neural crest cell migration involved in outflow tract morphogenesis; IMP:MGI.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IMP:MGI.
DR GO; GO:0071372; P:cellular response to follicle-stimulating hormone stimulus; IDA:MGI.
DR GO; GO:0044751; P:cellular response to human chorionic gonadotropin stimulus; IDA:MGI.
DR GO; GO:0070301; P:cellular response to hydrogen peroxide; ISO:MGI.
DR GO; GO:0071373; P:cellular response to luteinizing hormone stimulus; IDA:MGI.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; ISO:MGI.
DR GO; GO:0071310; P:cellular response to organic substance; IDA:MGI.
DR GO; GO:0034599; P:cellular response to oxidative stress; IMP:MGI.
DR GO; GO:1904888; P:cranial skeletal system development; IDA:MGI.
DR GO; GO:0048066; P:developmental pigmentation; IBA:GO_Central.
DR GO; GO:0035050; P:embryonic heart tube development; IMP:MGI.
DR GO; GO:0048706; P:embryonic skeletal system development; IGI:MGI.
DR GO; GO:0086100; P:endothelin receptor signaling pathway; IGI:MGI.
DR GO; GO:0086101; P:endothelin receptor signaling pathway involved in heart process; IMP:MGI.
DR GO; GO:0048484; P:enteric nervous system development; IEA:InterPro.
DR GO; GO:0061028; P:establishment of endothelial barrier; IDA:MGI.
DR GO; GO:0060324; P:face development; IDA:MGI.
DR GO; GO:0048144; P:fibroblast proliferation; ISO:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:MGI.
DR GO; GO:0010467; P:gene expression; IMP:MGI.
DR GO; GO:0072011; P:glomerular endothelium development; IDA:MGI.
DR GO; GO:0003094; P:glomerular filtration; IDA:MGI.
DR GO; GO:0032835; P:glomerulus development; IMP:MGI.
DR GO; GO:0060322; P:head development; IMP:MGI.
DR GO; GO:0007507; P:heart development; IMP:MGI.
DR GO; GO:0030202; P:heparin metabolic process; IGI:MGI.
DR GO; GO:0001821; P:histamine secretion; ISO:MGI.
DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IGI:MGI.
DR GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
DR GO; GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; IMP:MGI.
DR GO; GO:1903537; P:meiotic cell cycle process involved in oocyte maturation; IMP:MGI.
DR GO; GO:0097152; P:mesenchymal cell apoptotic process; IMP:MGI.
DR GO; GO:0042474; P:middle ear morphogenesis; IMP:MGI.
DR GO; GO:0007005; P:mitochondrion organization; IDA:MGI.
DR GO; GO:0000278; P:mitotic cell cycle; IMP:MGI.
DR GO; GO:0010259; P:multicellular organism aging; IMP:MGI.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI.
DR GO; GO:0014032; P:neural crest cell development; IMP:MGI.
DR GO; GO:0014033; P:neural crest cell differentiation; IMP:MGI.
DR GO; GO:0014034; P:neural crest cell fate commitment; IMP:MGI.
DR GO; GO:0050905; P:neuromuscular process; IMP:MGI.
DR GO; GO:0031175; P:neuron projection development; IMP:MGI.
DR GO; GO:0016322; P:neuron remodeling; IMP:MGI.
DR GO; GO:0003357; P:noradrenergic neuron differentiation; IMP:MGI.
DR GO; GO:0042415; P:norepinephrine metabolic process; IMP:MGI.
DR GO; GO:0043084; P:penile erection; ISO:MGI.
DR GO; GO:0061626; P:pharyngeal arch artery morphogenesis; IMP:MGI.
DR GO; GO:1903210; P:podocyte apoptotic process; IMP:MGI.
DR GO; GO:0072112; P:podocyte differentiation; IDA:MGI.
DR GO; GO:0051928; P:positive regulation of calcium ion transport; ISO:MGI.
DR GO; GO:2001259; P:positive regulation of cation channel activity; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI.
DR GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; ISO:MGI.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:MGI.
DR GO; GO:0050729; P:positive regulation of inflammatory response; ISO:MGI.
DR GO; GO:0090184; P:positive regulation of kidney development; ISO:MGI.
DR GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; ISO:MGI.
DR GO; GO:0042482; P:positive regulation of odontogenesis; ISO:MGI.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; ISO:MGI.
DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; ISO:MGI.
DR GO; GO:0010737; P:protein kinase A signaling; ISO:MGI.
DR GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; ISO:MGI.
DR GO; GO:0006468; P:protein phosphorylation; IMP:MGI.
DR GO; GO:0071806; P:protein transmembrane transport; IDA:MGI.
DR GO; GO:0008217; P:regulation of blood pressure; IMP:MGI.
DR GO; GO:0050678; P:regulation of epithelial cell proliferation; ISO:MGI.
DR GO; GO:0010827; P:regulation of glucose transmembrane transport; IDA:MGI.
DR GO; GO:0002027; P:regulation of heart rate; IMP:MGI.
DR GO; GO:1905871; P:regulation of protein localization to cell leading edge; IMP:MGI.
DR GO; GO:0097018; P:renal albumin absorption; IDA:MGI.
DR GO; GO:0070294; P:renal sodium ion absorption; IMP:MGI.
DR GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IMP:MGI.
DR GO; GO:1905144; P:response to acetylcholine; IMP:MGI.
DR GO; GO:0001975; P:response to amphetamine; IMP:MGI.
DR GO; GO:0001666; P:response to hypoxia; IMP:MGI.
DR GO; GO:0032496; P:response to lipopolysaccharide; ISO:MGI.
DR GO; GO:0043278; P:response to morphine; ISO:MGI.
DR GO; GO:0010033; P:response to organic substance; IGI:MGI.
DR GO; GO:0009611; P:response to wounding; IMP:MGI.
DR GO; GO:0007266; P:Rho protein signal transduction; ISO:MGI.
DR GO; GO:1902287; P:semaphorin-plexin signaling pathway involved in axon guidance; IMP:MGI.
DR GO; GO:0019233; P:sensory perception of pain; ISO:MGI.
DR GO; GO:0048659; P:smooth muscle cell proliferation; ISO:MGI.
DR GO; GO:0055078; P:sodium ion homeostasis; IGI:MGI.
DR GO; GO:0042305; P:specification of segmental identity, mandibular segment; IMP:MGI.
DR GO; GO:0007382; P:specification of segmental identity, maxillary segment; IMP:MGI.
DR GO; GO:0048485; P:sympathetic nervous system development; IMP:MGI.
DR GO; GO:0097492; P:sympathetic neuron axon guidance; IGI:MGI.
DR GO; GO:0030878; P:thyroid gland development; IMP:MGI.
DR GO; GO:0097084; P:vascular associated smooth muscle cell development; IMP:MGI.
DR GO; GO:0042310; P:vasoconstriction; IMP:MGI.
DR InterPro; IPR000499; Endthln_rcpt.
DR InterPro; IPR002175; ETA_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00570; ENDOTHELINAR.
DR PRINTS; PR00366; ENDOTHELINR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Phosphoprotein; Receptor; Reference proteome; Signal; Transducer;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..427
FT /note="Endothelin-1 receptor"
FT /id="PRO_0000012722"
FT TOPO_DOM 21..80
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..102
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..112
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..132
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 133..159
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..181
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..205
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..229
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..256
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..278
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..306
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..328
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 329..347
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..372
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 373..427
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 408..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 425
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P28088"
FT CARBOHYD 29
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 62
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 242
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 158..239
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 427 AA; 48578 MW; 10142BE73B028233 CRC64;
MSIFCLAAYF WLTMVGGVMA DNPERYSANL SSHMEDFTPF PGTEINFLGT THRPPNLALP
SNGSMHGYCP QQTKITTAFK YINTVISCTI FIVGMVGNAT LLRIIYQNKC MRNGPNALIA
SLALGDLIYV VIDLPINVFK LLAGRWPFDH NDFGVFLCKL FPFLQKSSVG ITVLNLCALS
VDRYRAVASW SRVQGIGIPL ITAIEIVSIW ILSFILAIPE AIGFVMVPFE YKGELHRTCM
LNATSKFMEF YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ
RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYDEMDKNR CELLSFLLLM DYIGINLATM
NSCINPIALY FVSKKFKNCF QSCLCCCCHQ SKSLMTSVPM NGTSIQWKNQ EQNNHNTERS
SHKDSMN
