EDNRA_RAT
ID EDNRA_RAT Reviewed; 426 AA.
AC P26684;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 2.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Endothelin-1 receptor {ECO:0000305};
DE AltName: Full=Endothelin receptor type A {ECO:0000312|RGD:2535};
DE Short=ET-A;
DE Short=ET-AR;
DE Flags: Precursor;
GN Name=Ednra {ECO:0000312|RGD:2535};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lung;
RX PubMed=1312429; DOI=10.1210/endo.130.4.1312429;
RA Hori S., Komatsu Y., Shigemoto R., Mizuno N., Nakanishi S.;
RT "Distinct tissue distribution and cellular localization of two messenger
RT ribonucleic acids encoding different subtypes of rat endothelin
RT receptors.";
RL Endocrinology 130:1885-1895(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1849646; DOI=10.1073/pnas.88.8.3185;
RA Lin H.Y., Kaji E.H., Winkel G.K., Ives H.E., Lodish H.F.;
RT "Cloning and functional expression of a vascular smooth muscle endothelin 1
RT receptor.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:3185-3189(1991).
CC -!- FUNCTION: Receptor for endothelin-1. Mediates its action by association
CC with G proteins that activate a phosphatidylinositol-calcium second
CC messenger system. The rank order of binding affinities for ET-A is: ET1
CC > ET2 >> ET3.
CC -!- SUBUNIT: Interacts with HDAC7 and KAT5. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in vascular smooth muscle
CC cells of a variety of issues, bronchial smooth muscle cells,
CC myocardium, and the pituitary gland.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Endothelin receptor subfamily. EDNRA sub-subfamily.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; M60786; AAA41114.1; -; mRNA.
DR PIR; A40440; A40440.
DR RefSeq; NP_036682.1; NM_012550.2.
DR RefSeq; XP_008770693.1; XM_008772471.1.
DR AlphaFoldDB; P26684; -.
DR SMR; P26684; -.
DR STRING; 10116.ENSRNOP00000054967; -.
DR BindingDB; P26684; -.
DR ChEMBL; CHEMBL4566; -.
DR DrugCentral; P26684; -.
DR GuidetoPHARMACOLOGY; 219; -.
DR GlyGen; P26684; 2 sites.
DR PhosphoSitePlus; P26684; -.
DR PaxDb; P26684; -.
DR GeneID; 24326; -.
DR KEGG; rno:24326; -.
DR UCSC; RGD:2535; rat.
DR CTD; 1909; -.
DR RGD; 2535; Ednra.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; P26684; -.
DR OrthoDB; 876925at2759; -.
DR PhylomeDB; P26684; -.
DR TreeFam; TF331292; -.
DR Reactome; R-RNO-375276; Peptide ligand-binding receptors.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR PRO; PR:P26684; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0071944; C:cell periphery; ISO:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IDA:RGD.
DR GO; GO:0031965; C:nuclear membrane; IDA:RGD.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030315; C:T-tubule; IDA:RGD.
DR GO; GO:0004962; F:endothelin receptor activity; IDA:RGD.
DR GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; ISO:RGD.
DR GO; GO:0007568; P:aging; IEP:RGD.
DR GO; GO:0001525; P:angiogenesis; ISO:RGD.
DR GO; GO:0035904; P:aorta development; ISO:RGD.
DR GO; GO:0014824; P:artery smooth muscle contraction; ISO:RGD.
DR GO; GO:0003228; P:atrial cardiac muscle tissue development; ISO:RGD.
DR GO; GO:0048675; P:axon extension; ISO:RGD.
DR GO; GO:0007411; P:axon guidance; ISO:RGD.
DR GO; GO:0060385; P:axonogenesis involved in innervation; ISO:RGD.
DR GO; GO:0001974; P:blood vessel remodeling; ISO:RGD.
DR GO; GO:0001569; P:branching involved in blood vessel morphogenesis; ISO:RGD.
DR GO; GO:0070588; P:calcium ion transmembrane transport; ISO:RGD.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; ISO:RGD.
DR GO; GO:0003207; P:cardiac chamber formation; ISO:RGD.
DR GO; GO:0003253; P:cardiac neural crest cell migration involved in outflow tract morphogenesis; ISO:RGD.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; ISO:RGD.
DR GO; GO:0071372; P:cellular response to follicle-stimulating hormone stimulus; ISO:RGD.
DR GO; GO:0044751; P:cellular response to human chorionic gonadotropin stimulus; ISO:RGD.
DR GO; GO:0071373; P:cellular response to luteinizing hormone stimulus; ISO:RGD.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IMP:RGD.
DR GO; GO:0071310; P:cellular response to organic substance; ISO:RGD.
DR GO; GO:0034599; P:cellular response to oxidative stress; ISO:RGD.
DR GO; GO:1904888; P:cranial skeletal system development; ISO:RGD.
DR GO; GO:0048066; P:developmental pigmentation; IBA:GO_Central.
DR GO; GO:0035050; P:embryonic heart tube development; ISO:RGD.
DR GO; GO:0048706; P:embryonic skeletal system development; ISO:RGD.
DR GO; GO:0086100; P:endothelin receptor signaling pathway; ISO:RGD.
DR GO; GO:0086101; P:endothelin receptor signaling pathway involved in heart process; ISO:RGD.
DR GO; GO:0048484; P:enteric nervous system development; IEA:InterPro.
DR GO; GO:0061028; P:establishment of endothelial barrier; ISO:RGD.
DR GO; GO:0060324; P:face development; ISO:RGD.
DR GO; GO:0048144; P:fibroblast proliferation; IMP:RGD.
DR GO; GO:0010467; P:gene expression; ISO:RGD.
DR GO; GO:0072011; P:glomerular endothelium development; ISO:RGD.
DR GO; GO:0003094; P:glomerular filtration; IMP:RGD.
DR GO; GO:0032835; P:glomerulus development; ISO:RGD.
DR GO; GO:0060322; P:head development; ISO:RGD.
DR GO; GO:0007507; P:heart development; ISO:RGD.
DR GO; GO:0030202; P:heparin metabolic process; ISO:RGD.
DR GO; GO:0001821; P:histamine secretion; IMP:RGD.
DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; ISO:RGD.
DR GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR GO; GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; ISO:RGD.
DR GO; GO:0060137; P:maternal process involved in parturition; IEP:RGD.
DR GO; GO:1903537; P:meiotic cell cycle process involved in oocyte maturation; ISO:RGD.
DR GO; GO:0097152; P:mesenchymal cell apoptotic process; ISO:RGD.
DR GO; GO:0042474; P:middle ear morphogenesis; ISO:RGD.
DR GO; GO:0007005; P:mitochondrion organization; ISO:RGD.
DR GO; GO:0000278; P:mitotic cell cycle; ISO:RGD.
DR GO; GO:0010259; P:multicellular organism aging; ISO:RGD.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.
DR GO; GO:0014032; P:neural crest cell development; ISO:RGD.
DR GO; GO:0014033; P:neural crest cell differentiation; ISO:RGD.
DR GO; GO:0014034; P:neural crest cell fate commitment; ISO:RGD.
DR GO; GO:0050905; P:neuromuscular process; ISO:RGD.
DR GO; GO:0031175; P:neuron projection development; ISO:RGD.
DR GO; GO:0016322; P:neuron remodeling; ISO:RGD.
DR GO; GO:0003357; P:noradrenergic neuron differentiation; ISO:RGD.
DR GO; GO:0042415; P:norepinephrine metabolic process; ISO:RGD.
DR GO; GO:0043084; P:penile erection; IMP:RGD.
DR GO; GO:0061626; P:pharyngeal arch artery morphogenesis; ISO:RGD.
DR GO; GO:1903210; P:podocyte apoptotic process; ISO:RGD.
DR GO; GO:0072112; P:podocyte differentiation; ISO:RGD.
DR GO; GO:0051928; P:positive regulation of calcium ion transport; IMP:RGD.
DR GO; GO:2001259; P:positive regulation of cation channel activity; ISO:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:RGD.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:RGD.
DR GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; IMP:RGD.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:RGD.
DR GO; GO:0050729; P:positive regulation of inflammatory response; IMP:RGD.
DR GO; GO:0090184; P:positive regulation of kidney development; IMP:RGD.
DR GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IMP:RGD.
DR GO; GO:0042482; P:positive regulation of odontogenesis; IMP:RGD.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IMP:RGD.
DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IMP:RGD.
DR GO; GO:0010737; P:protein kinase A signaling; ISO:RGD.
DR GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; IMP:RGD.
DR GO; GO:0006468; P:protein phosphorylation; ISO:RGD.
DR GO; GO:0071806; P:protein transmembrane transport; ISO:RGD.
DR GO; GO:0008217; P:regulation of blood pressure; ISO:RGD.
DR GO; GO:0050678; P:regulation of epithelial cell proliferation; IMP:RGD.
DR GO; GO:0010827; P:regulation of glucose transmembrane transport; ISO:RGD.
DR GO; GO:0002027; P:regulation of heart rate; ISO:RGD.
DR GO; GO:1905871; P:regulation of protein localization to cell leading edge; ISO:RGD.
DR GO; GO:0097018; P:renal albumin absorption; ISO:RGD.
DR GO; GO:0070294; P:renal sodium ion absorption; ISO:RGD.
DR GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; ISO:RGD.
DR GO; GO:1905144; P:response to acetylcholine; ISO:RGD.
DR GO; GO:0001975; P:response to amphetamine; ISO:RGD.
DR GO; GO:0001666; P:response to hypoxia; ISO:RGD.
DR GO; GO:0032496; P:response to lipopolysaccharide; IMP:RGD.
DR GO; GO:0043278; P:response to morphine; IMP:RGD.
DR GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
DR GO; GO:0010033; P:response to organic substance; ISO:RGD.
DR GO; GO:0009611; P:response to wounding; ISO:RGD.
DR GO; GO:0007266; P:Rho protein signal transduction; IMP:RGD.
DR GO; GO:1902287; P:semaphorin-plexin signaling pathway involved in axon guidance; ISO:RGD.
DR GO; GO:0019233; P:sensory perception of pain; IMP:RGD.
DR GO; GO:0048659; P:smooth muscle cell proliferation; IMP:RGD.
DR GO; GO:0055078; P:sodium ion homeostasis; ISO:RGD.
DR GO; GO:0048485; P:sympathetic nervous system development; ISO:RGD.
DR GO; GO:0097492; P:sympathetic neuron axon guidance; ISO:RGD.
DR GO; GO:0030878; P:thyroid gland development; ISO:RGD.
DR GO; GO:0097084; P:vascular associated smooth muscle cell development; ISO:RGD.
DR GO; GO:0042310; P:vasoconstriction; IMP:RGD.
DR InterPro; IPR000499; Endthln_rcpt.
DR InterPro; IPR002175; ETA_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00570; ENDOTHELINAR.
DR PRINTS; PR00366; ENDOTHELINR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Phosphoprotein; Receptor; Reference proteome; Signal; Transducer;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..426
FT /note="Endothelin-1 receptor"
FT /id="PRO_0000012724"
FT TOPO_DOM 21..80
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..102
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..112
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..132
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 133..159
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..181
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..205
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..229
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..256
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..278
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..306
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..328
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 329..347
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..372
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 373..426
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 424
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P28088"
FT CARBOHYD 29
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 62
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 158..239
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 46
FT /note="N -> D (in Ref. 2; AAA41114)"
FT /evidence="ECO:0000305"
FT CONFLICT 53
FT /note="Q -> R (in Ref. 2; AAA41114)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 426 AA; 48245 MW; E8A24683DBB78BB8 CRC64;
MGVLCFLASF WLALVGGAIA DNAERYSANL SSHVEDFTPF PGTEFNFLGT TLQPPNLALP
SNGSMHGYCP QQTKITTAFK YINTVISCTI FIVGMVGNAT LLRIIYQNKC MRNGPNALIA
SLALGDLIYV VIDLPINVFK LLAGRWPFDH NDFGVFLCKL FPFLQKSSVG ITVLNLCALS
VDRYRAVASW SRVQGIGIPL ITAIEIVSIW ILSFILAIPE AIGFVMVPFE YKGEQHRTCM
LNATTKFMEF YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ
RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYDEMDKNR CELLSFLLLM DYIGINLATM
NSCINPIALY FVSKKFKNCF QSCLCCCCHQ SKSLMTSVPM NGTSIQWKNQ EQNHNTERSS
HKDSMN
