EDR2L_ARATH
ID EDR2L_ARATH Reviewed; 719 AA.
AC Q8VZF6; Q9FH45;
DT 14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 124.
DE RecName: Full=Protein ENHANCED DISEASE RESISTANCE 2-like;
GN Name=EDR2L; OrderedLocusNames=At5g45560; ORFNames=MFC19.23;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10470850; DOI=10.1093/dnares/6.3.183;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Kotani H.,
RA Miyajima N., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. IX. Sequence
RT features of the regions of 1,011,550 bp covered by seventeen P1 and TAC
RT clones.";
RL DNA Res. 6:183-195(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- FUNCTION: Binds to phosphatidylinositol-4-phosphate (PtdIns(4)P). May
CC regulate the salicylic acid- (SA-) mediated resistance to pathogens (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}. Cell membrane
CC {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Endosome
CC membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
CC -!- DOMAIN: The pleckstrin homology domain (3-110) binds to
CC phosphatidylinositol-4-phosphate (PtdIns(4)P). {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB11194.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB022213; BAB11194.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB018113; BAB11194.1; JOINED; Genomic_DNA.
DR EMBL; CP002688; AED95268.1; -; Genomic_DNA.
DR EMBL; AY064989; AAL57642.1; -; mRNA.
DR RefSeq; NP_199369.2; NM_123924.3.
DR AlphaFoldDB; Q8VZF6; -.
DR SMR; Q8VZF6; -.
DR STRING; 3702.AT5G45560.1; -.
DR iPTMnet; Q8VZF6; -.
DR PaxDb; Q8VZF6; -.
DR PRIDE; Q8VZF6; -.
DR ProteomicsDB; 224739; -.
DR EnsemblPlants; AT5G45560.1; AT5G45560.1; AT5G45560.
DR GeneID; 834592; -.
DR Gramene; AT5G45560.1; AT5G45560.1; AT5G45560.
DR KEGG; ath:AT5G45560; -.
DR Araport; AT5G45560; -.
DR TAIR; locus:2163548; AT5G45560.
DR eggNOG; ENOG502QS0N; Eukaryota.
DR HOGENOM; CLU_018946_0_0_1; -.
DR InParanoid; Q8VZF6; -.
DR OMA; INICKHE; -.
DR OrthoDB; 268655at2759; -.
DR PhylomeDB; Q8VZF6; -.
DR PRO; PR:Q8VZF6; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8VZF6; baseline and differential.
DR Genevisible; Q8VZF6; AT.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR Gene3D; 2.30.29.30; -; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR045096; EDR2-like.
DR InterPro; IPR009769; EDR2_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR12136; PTHR12136; 1.
DR Pfam; PF07059; EDR2_C; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00234; START; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50848; START; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Endoplasmic reticulum; Endosome; Membrane; Plant defense;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..719
FT /note="Protein ENHANCED DISEASE RESISTANCE 2-like"
FT /id="PRO_0000428906"
FT TRANSMEM 665..685
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 3..110
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT DOMAIN 180..392
FT /note="START"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00197"
FT REGION 134..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..160
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..457
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..478
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 719 AA; 81725 MW; 240A36A041D69E34 CRC64;
MSKVVYEGWM VRYGRRKIGR SYIHMRYFVL EPRLLAYYKK KPQDNQLPIK TMVIDGNCRV
EDRGLKTHHG HMVYVLSIYN KKEKHHRITM AAFNIQEALM WKEKIECVID QHQDSLVPSG
QQYVSFEYKP GMDAGRTASS SDHESPFSAL EDENDSQRDL LRRTTIGNGP PESILDWTKE
FDAELSNQSS SNQAFSRKHW RLLQCQNGLR IFEELLEVDY LPRSCSRAMK AVGVVEATCE
EIFELVMSMD GTRYEWDCSF HNGRLVEEVD GHTAILYHRL LLDWFPMVVW PRDLCYVRYW
RRNDDGSYVV LFRSREHENC GPQPGFVRAH LESGGFNIAP LKPRNGRPRT QVQHLIQIDL
KGWGSGYLPA FQQHCLLQML NSVSGLREWF SQTDDRGQPI RIPVMVNMAS SSLALGKGGK
HHHKSSLSID QTNGASRNSV LMDEDSDDDD EFQIPDSEPE PETSKQDQET DAKKTEEPAL
NIDLSCFSGN LRHDDNENAR NCWRISDGNN FKVRGKSFCD DKRKIPAGKH LMDLVAVDWF
KDTKRMDHVV RRKGCAAQVA AEKGLFSTVV NVQVPGSTHY SMVFYFVTKE LVPGSLFQRF
VDGDDEFRNS RLKLIPLVPK GSWIVRQSVG STPCLLGKAV DCNYIRGPTY LEIDVDIGSS
TVANGVLGLV IGVITSLVVE MAFLVQANTP EELPERLIGA VRVSHVELSS AIVPNLDSD
