ID   EDRF1_MOUSE             Reviewed;        1239 AA.
AC   Q6GQV7; Q80ZY3; Q8R3P5;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Erythroid differentiation-related factor 1;
GN   Name=Edrf1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and FVB/N; TISSUE=Fetal brain, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Kidney, Lung, Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Transcription factor involved in erythroid differentiation.
CC       Involved in transcriptional activation of the globin gene (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH24916.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAH46235.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC024916; AAH24916.1; ALT_INIT; mRNA.
DR   EMBL; BC046235; AAH46235.1; ALT_INIT; mRNA.
DR   EMBL; BC072596; AAH72596.1; -; mRNA.
DR   RefSeq; NP_835216.3; NM_178115.4.
DR   AlphaFoldDB; Q6GQV7; -.
DR   BioGRID; 229562; 2.
DR   STRING; 10090.ENSMUSP00000059166; -.
DR   iPTMnet; Q6GQV7; -.
DR   PhosphoSitePlus; Q6GQV7; -.
DR   EPD; Q6GQV7; -.
DR   MaxQB; Q6GQV7; -.
DR   PaxDb; Q6GQV7; -.
DR   PRIDE; Q6GQV7; -.
DR   ProteomicsDB; 277684; -.
DR   GeneID; 214764; -.
DR   KEGG; mmu:214764; -.
DR   CTD; 26098; -.
DR   MGI; MGI:1919831; Edrf1.
DR   eggNOG; ENOG502QTNC; Eukaryota.
DR   InParanoid; Q6GQV7; -.
DR   OMA; AFLYCNM; -.
DR   OrthoDB; 323777at2759; -.
DR   PhylomeDB; Q6GQV7; -.
DR   BioGRID-ORCS; 214764; 11 hits in 73 CRISPR screens.
DR   ChiTaRS; Edrf1; mouse.
DR   PRO; PR:Q6GQV7; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q6GQV7; protein.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI.
PE   1: Evidence at protein level;
KW   Activator; Nucleus; Reference proteome; Repeat; TPR repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1239
FT                   /note="Erythroid differentiation-related factor 1"
FT                   /id="PRO_0000244261"
FT   REPEAT          693..726
FT                   /note="TPR 1"
FT   REPEAT          914..953
FT                   /note="TPR 2"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          219..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          517..559
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          620..646
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        225..241
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        531..546
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1239 AA;  138834 MW;  53C896457CF75797 CRC64;
     MGDPKEAGAE ASPSGAAARG GLSLLSQADS EEPSAQGSAL FLGGNEVKSR AVVKYSSAPP
     RTAFARLEEK TDLKLPPANW LRESAKLGPA GTTILGNSKK SKPFSSFGMA YDFIDSVGND
     VDVVSDSENI KKLLKIPYSK SHVSMAVHRI GRTLLLDELD IQELFMRSSQ TGDWTWLKEF
     YQRLIDQKWQ RKKKSKEHWY QKAILSKFLY YSINGDGAAQ PVPSPAEQEE SSSSQQTHES
     EGAAWPAPFE MPSSVSEDPS ASSQGREPLE PSCIVGHVAS APKEQNLTTL FNDGENSQGL
     KNDFVRNILW TFEDIHMLVG SNMPIFGGGR YPAVSLRLRD NNKPINVLTG IDYWLDNLIC
     NVPELVMCFH VNGIVQKYEM IKTEEIPNLE NSNFSTKVIK DIAQNILSFL KSNCTKEGHT
     YWLFKASGSD IVKLYDLTTL CEETEDKYQN PFTMPVAILL YKVACNMMMK KNQNKKHYGT
     IRTLLLNCVK LLDKSRHPQI IASANYMLSE LFQLDEPKKE ESSDSPLNEN SDESYSEEEE
     EMADSDENGS YSTSSDPADD NKAVAIIKSV GELSVPEKYK SIHQIRPSCA FPVCHDTEER
     CRLVLSYVLE GLKSVDSSIK KESDLPAADP STPIPLKYED ESTRGGPEGL EKQMALFLDK
     MGSIQKGSCS GQSGMTPGSW QHKMKLQLIL KSSKAYYILS DAAMSLQKYG RALRYIKLAL
     QSHDTYCCLC TNMLSEVLLF LSQYLTLCGD IQLMLAQNAN NRAAHLEEFN YQTKEDQEIL
     HSLHRESSCQ GFAWATDLST DLESQLSVSC KCYEAANEIL QFSDLKSQNP EHYVQVLKRM
     GNIRNEIGVF YMNQAAALQG ERVVSKSVSA AEQQLWKKSF SCFEKGIHNF ESIDDATNAA
     LLLCNTGRLM RVCAQAHCGA EDEFKREFSP EEGLYYSKAV DYYLKALRSL GTRDMHPIVW
     DSVNWELSTT YFTMATLQQD YAPLSRKAQE QIEKEVSEAM MKSLKHCDVD SATARQPLCQ
     YRAATIHHRL ASMYHSCLRN QVGDEHLRKQ HRVLADLHYS KAAKLFQLLK DAPCELLRVQ
     LERVAFAEFQ MSSQNSNVGK LKTLSGALDI MVRTEHAFQL IRKELVEECD QPKNDEATPA
     ADSSPNLNRE EVIKLLSIFE SRLSFLLLQS IKLMSSSKRK MSSNAEEDIV LQTNKQIYSQ
     LLRATANRNS TLLERIEVVI CLLEQLASGS SRSSGSAVP