ID   EDRF1_PONAB             Reviewed;        1204 AA.
AC   Q5R9R1;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Erythroid differentiation-related factor 1;
GN   Name=EDRF1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor involved in erythroid differentiation.
CC       Involved in transcriptional activation of the globin gene (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; CR859321; CAH91499.1; -; mRNA.
DR   AlphaFoldDB; Q5R9R1; -.
DR   STRING; 9601.ENSPPYP00000003210; -.
DR   eggNOG; ENOG502QTNC; Eukaryota.
DR   InParanoid; Q5R9R1; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Repeat; TPR repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1204
FT                   /note="Erythroid differentiation-related factor 1"
FT                   /id="PRO_0000244262"
FT   REPEAT          693..726
FT                   /note="TPR 1"
FT   REPEAT          920..953
FT                   /note="TPR 2"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          220..264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          483..527
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          586..613
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        220..243
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        497..512
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        513..527
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1204 AA;  135038 MW;  EA51001246C0A4C6 CRC64;
     MGDAKEAGAE GPPAGAAARE GLSLLSQAES EESSAQGSAL FLGGNEVKSR AVVKYSSAPP
     RTAFARLEEK TDLKLPPANW LRESAKLGPA GTTILGNSKK SKPFSSFGMA YDFIDSVGND
     VDVVSDSENI KKLLKIPYSK SHVSMAVHRI GRTLLLDELD IQELFMRSSQ TGDWTWLKEF
     YQRLIDQKWQ RKKKSKEHWY QKAILSKFLY YSINGDGAAQ PVSSTTEQQE SSSSDQTNDS
     EGASWPAPFE MPSSVSEDPS ASSQGLKNDF VRNILWTFED IHMLVGSNMP IFGGGRYPAV
     SLRLRDNNKP INVLTGIDYW LDNLICNVPE LVMCFHVNGI VQKYEMIKTE EIPNLENSNF
     STKVIKDIAQ NILSFLKSNC TKEGHTYWLF KASGSDIVKL YDLTTLCEET EDKYQNPFTM
     PVAILLYKVA CNMMMKKNQN KKHYGTIRTL LLNCLKLLDK SRHPQIIASA NYMLSELFQL
     DEPKKEENSE SPLNENSDES YSEEEEEMPD SDENGSYSTS SDPSDDSNAV AIIKSVGELS
     VPEKYKSIHQ IRPSCAFPVC HDTEERCRLV LSYVLEGLKS VDSSIKKESD LPAADPSTPI
     PLKYEDESSR GGPEGLEKQM ALFLDKMGSL QKGNYSSQSG MIPGSWQHKM KLQLILKSSK
     AYYVLSDAAM SLQKYGRALR YIKLALQSHD TYCCLCTNML SEVLLFLSQY LTLCGDIQLM
     LAQNANNRAA HLEEFHYRTK EDQEILHSLH RESSCQGFAW ATDLSTDLES QLSVSCKCYE
     ATNEILQFSD LKSQNPEHYV QVLKRMGNIR NEIGVFYMNQ AAALQSERVV SKSVSAAEQQ
     LWKKSFSCFE KGIHNFESIE DATNAALLLC NTGRLMRICA QAHCGAGDEF KREFSPEEGL
     YYNKAIDYYL KALRSLGTRD IHPAVWDSVN WELSTTYFTM ATLQQDYAPL SRKAQEQIEK
     EVSEAMMKSL KYCDVDSVSA RQPLCQYRAA TIHHRLASMY HSCLRNQLGD EHLRKQHRVL
     ADLHYSKAAK LFQLLKDAPC ELLRVQLERV AFAEFQMTSQ NSNVGKLKTL SGALNIMVRT
     EHAFQLIQKE LIEELGQPKS GDAAVAADAS PSLNREEVMK LLSIFESRLS FLLLQSIKLL
     SSTKKKTSNN IEDDAVLKTN KHIYSQLLRA TANKTATLLE RINVIIHLLG QLAAGSAASS
     NAVQ