ID   EDS1_YEAS7              Reviewed;         919 AA.
AC   A6ZKX7;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Transcriptional regulatory protein EDS1;
DE   AltName: Full=Expression dependent on SLT2 protein 1;
GN   Name=EDS1; ORFNames=SCY_0247;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- SUBUNIT: Binds DNA in a sequence-specific manner. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; AAFW02000011; EDN64646.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZKX7; -.
DR   EnsemblFungi; EDN64646; EDN64646; SCY_0247.
DR   HOGENOM; CLU_006525_0_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..919
FT                   /note="Transcriptional regulatory protein EDS1"
FT                   /id="PRO_0000408010"
FT   DNA_BIND        56..85
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          297..338
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..39
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        319..338
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   919 AA;  103375 MW;  5398365D79AAA93D CRC64;
     MSHHVPNLYG TPIRDPHERK RNSASMGEVN QSVSSRNCER GSEKGTKQRK KASRACDQCR
     RKRIKCRFDK HTGVCQGCLE VGEKCQFIRV PLKRGPAKKR ASVVSIEKFS SDNDPLQYRP
     RTHSYPMNSG NNYLPSLARN SSFPSISSLF VPSITAQSQQ FVKVPYDDIK RRSSLATLGS
     DSSISTEFGG NYRLDENLNV RQEGKDIVAK GMITPVEEMG ACSSNVRRQG SQSLPIQEQR
     ASPYINPFIS GRSRLSSLSY TSEATTSEGN TQGKNQCMLT PNSVRSIEKE RLNSLTAGCP
     NKKLGTDGRS DKWDKNSTWK PVYRSSNPSH PSTEKNVSLN QEASAKPLML GTYRQFDATS
     FYKVLGIYYN FFHINFPVIP INKSKFTDML DPEKPNVIDE IRQINNEIIQ CFKTALEVLV
     FCKIKQRRSS KSTKSWSRDS LCDFQKGLYY IQNFNKCIAD CFQSLITIKP VLKQNSSVIP
     SRIKFIYFST IIVLNFILIL AGEESSLLLG PSVGVFNEFQ AHKLFLPFEN TSPMLLLNSN
     EESGDEILDY AVLFKRLYIL LNILDTLQSF RLGQPKLINL NFGSAIETYF SDKTGHNQVV
     EKAPVALDNI LRNLKLGEFI TYFVLNRKSL QVNVPHHLLF TNQTDYGEFA VEKGEHDNIA
     GKFETLLKKK EILIRKLLNI EQKNDHILEN CCNSDAEMKN IGELVCSMIT LVSGILDSIT
     NMNAENSVDL DSKPLPNAYF AQDSEEELMS PTQSITSNLA SEENTRCTTK DLMGTVSIFM
     LPMVEECYNI ISLIGPIPTT LISLYIRNGN MAKGINDRIM TLSTALNELV QITALFNTLE
     PFRKNAHDRA KRYYVSATSS TGCYESVMKS MYSGKCAASN ASNVAPSEEE NKKILKKFAD
     IGWKLMDDSE LGCCCCFFN