ID   EDS1_YEAS8              Reviewed;         919 AA.
AC   D3UEC9;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Transcriptional regulatory protein EDS1;
DE   AltName: Full=Expression dependent on SLT2 protein 1;
GN   Name=EDS1; ORFNames=EC1118_1B15_1640g;
OS   Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) (Baker's
OS   yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=643680;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lalvin EC1118 / Prise de mousse;
RX   PubMed=19805302; DOI=10.1073/pnas.0904673106;
RA   Novo M., Bigey F., Beyne E., Galeote V., Gavory F., Mallet S., Cambon B.,
RA   Legras J.-L., Wincker P., Casaregola S., Dequin S.;
RT   "Eukaryote-to-eukaryote gene transfer events revealed by the genome
RT   sequence of the wine yeast Saccharomyces cerevisiae EC1118.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:16333-16338(2009).
CC   -!- SUBUNIT: Binds DNA in a sequence-specific manner. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; FN393060; CBK39109.1; -; Genomic_DNA.
DR   AlphaFoldDB; D3UEC9; -.
DR   EnsemblFungi; CBK39109; CBK39109; EC1118_1B15_1640g.
DR   HOGENOM; CLU_006525_0_0_1; -.
DR   Proteomes; UP000000286; Chromosome II, Scaffold EC1118_1B15.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..919
FT                   /note="Transcriptional regulatory protein EDS1"
FT                   /id="PRO_0000408011"
FT   DNA_BIND        56..85
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          297..338
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..39
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        319..338
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   919 AA;  103329 MW;  6E1E19789F7A6DE0 CRC64;
     MSHHVPNLYG TPIRDPHEHK RNSASMGEVN QSVSSRNCER GSEKGTKQRK KASRACDQCR
     RKRIKCRFDK HTGVCQGCLE VGEKCQFIRV PLKRGPAKKR ASVASNEKFS SDNDPLQYRP
     RTHSYPMNSG NNYLPSLARN SSFPSISSLF VPSITAQSQQ FVKVPYDDIK RRSSLATLGS
     DSSISTEFGG NYRLDENLNV RQEGKDIVAK GMITPVEEMG ACSSNVRRQG SQSLPIQEQR
     ASPYINPFIS GRSRLSSLSY TSEATTSEGN TQGKNQCMLT PNSVRSIEKE RLNSLTAGCP
     NKKLGTDGRS DKWDKNSTWK PVYRSSNPSH PSTEKNVSLN QEASAKPLML GTYRQFDATS
     FYKVLGIYYN FFHINFPVIP INKSKFTDML DPEKPNVIDE IRQINNEIIQ CFKTALEVLV
     FCKIKQRRSS KSTKSWSRDS LCDFQKGLYY IQNFNKCIAD CFQSLITIKP VLKQNSSVIP
     SRIKFIYFST IIVLNFILIL AGEESSLLLG PSVGVFNEFQ AHKLFLPFEN TSPMLLLNSN
     EESGDEILDY AVLFKRLYIL LNILDTLQSF RLGQPKLINL NFGSAIETYF SDKTGHNQVV
     EKAPVALDNI LRNLKLGEFI TYFVLNRKSL QVNVPHHLLF TNQTDYGEFA VEKGEHDNIA
     GKFETLLKKK EILIRKLLNI EQKNDHILEN CCNSDAEMKN IGELVCSMIT LVSGILDSIT
     NMNAENSVDL DSKPLPNAYF AQDSEEELMS PTQSITSNLA SEENTRCTTK DLMGTVSIFM
     LPMVEECYNI ISLIGPIPTT LISLYIRNGN MAKGINDRIM TLSTALNELV QITALFNTLE
     PFRKNAHDRA KRYYVSATSS TGCYESVMKS MYSGKCAASN ASNVAPSEEE NKKILKKFAD
     IGWKLMDDSE LGCCCCFFN