ID   EDSP_CYNPY              Reviewed;         335 AA.
AC   P46058;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Epidermal differentiation-specific protein;
OS   Cynops pyrrhogaster (Japanese fire-bellied newt) (Molge pyrrhogaster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Caudata; Salamandroidea; Salamandridae; Pleurodelinae; Cynops.
OX   NCBI_TaxID=8330;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Takabatake T., Takeshima K., Takahashi T.;
RT   "Cloning of an epidermis-specific Cynops cDNA from neurula library.";
RL   Dev. Growth Differ. 34:277-283(1992).
CC   -!- TISSUE SPECIFICITY: Epidermis specific.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; D11395; BAA01991.1; -; mRNA.
DR   AlphaFoldDB; P46058; -.
DR   SMR; P46058; -.
DR   TCDB; 1.C.4.8.2; the aerolysin channel-forming toxin (aerolysin) family.
DR   InterPro; IPR004991; Aerolysin-like.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   Pfam; PF03318; ETX_MTX2; 1.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Repeat.
FT   CHAIN           1..335
FT                   /note="Epidermal differentiation-specific protein"
FT                   /id="PRO_0000057610"
FT   DOMAIN          2..42
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          43..81
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          87..126
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          127..169
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
SQ   SEQUENCE   335 AA;  37450 MW;  9F5090541A2DF7FD CRC64;
     MNTITVYEHS NFQGLHKTFT SDVPNLVNES FNDCISSVKI VGQPWILHQD INYSGQCLPL
     EEGEYSGISM NDGASSLRLI TDDLSNPQIT VYEHVNGGGK ALVLTEETNL AFGNMHDNIS
     SHRVQRGAWA LYEHINRGGR CIVARAGEYL ANYCTIGFND QVSHVYPLRA GKTSVTATIL
     WDRKKVESER NVQIDQYFYT NNTSIEQQFT ATSTKEFEKY VSHSFEFSNE TSIKVGTSFT
     LKGVVDINTE VSNTFTVKKG ETESFTTRKK AELSMPVKAP PRSKLTVNFM CKEITISVPV
     ELKIVRGSKT DIETGTYRCE SGTETYIDVQ SLPIS