ID   EEDA_XENLA              Reviewed;         438 AA.
AC   Q8UUP2; Q6AZP3;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Polycomb protein eed-A;
DE            Short=Xeed-A;
GN   Name=eed-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH EZH2; HDAC1 AND TAF9, AND
RP   DEVELOPMENTAL STAGE.
RC   TISSUE=Gastrula;
RX   PubMed=12095683; DOI=10.1016/s0378-1119(02)00588-7;
RA   Showell C., Cunliffe V.T.;
RT   "Identification of putative interaction partners for the Xenopus Polycomb-
RT   group protein Xeed.";
RL   Gene 291:95-104(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg, and Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Polycomb group (PcG) protein. Component of the prc2/eed-ezh2
CC       complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading
CC       to transcriptional repression of the affected target gene (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the prc2/eed-ezh2 complex (By similarity).
CC       Interacts with yy1 (By similarity). Can interact with ezh2, hdac1 and
CC       taf9. {ECO:0000250, ECO:0000269|PubMed:12095683}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Maternally and zygotically expressed. Expression
CC       declines at the mid-blastula transition. {ECO:0000269|PubMed:12095683}.
CC   -!- SIMILARITY: Belongs to the WD repeat ESC family. {ECO:0000305}.
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DR   EMBL; AJ421945; CAD19130.1; -; mRNA.
DR   EMBL; BC077511; AAH77511.1; -; mRNA.
DR   EMBL; BC097778; AAH97778.1; -; mRNA.
DR   RefSeq; NP_001089517.1; NM_001096048.1.
DR   AlphaFoldDB; Q8UUP2; -.
DR   SMR; Q8UUP2; -.
DR   GeneID; 734571; -.
DR   KEGG; xla:734571; -.
DR   CTD; 734571; -.
DR   Xenbase; XB-GENE-6255887; eed.L.
DR   OrthoDB; 1191277at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 734571; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0035098; C:ESC/E(Z) complex; ISS:UniProtKB.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0016571; P:histone methylation; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR037352; Polycomb_EED.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR10253:SF5; PTHR10253:SF5; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; WD repeat.
FT   CHAIN           1..438
FT                   /note="Polycomb protein eed-A"
FT                   /id="PRO_0000343729"
FT   REPEAT          88..131
FT                   /note="WD 1"
FT   REPEAT          139..182
FT                   /note="WD 2"
FT   REPEAT          185..225
FT                   /note="WD 3"
FT   REPEAT          231..270
FT                   /note="WD 4"
FT   REPEAT          301..338
FT                   /note="WD 5"
FT   REPEAT          356..396
FT                   /note="WD 6"
FT   REPEAT          405..438
FT                   /note="WD 7"
FT   REGION          1..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..54
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        10..13
FT                   /note="GNEM -> DAWV (in Ref. 2; AAH77511)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   438 AA;  49725 MW;  F408BBA0E290DBC3 CRC64;
     MSEASGRAAG NEMPAKKQKL SSDENSNPEL SGDENDDSVS IESGTNTERP DTPTNAANAP
     GRKAWGKGKW KSKKCKYSFK CVNSLKEDHN QPLFGVQFNW HSKEGDPLVF ATVGSNRVTL
     YECHPQGDIR LLQSYVDADA DENFYTCAWT YDSNTSHPLL AVAGSRGIIR IINPITMQCI
     KHYVGHGNAI NELKFHPRDP NLLLSVSKDH ALRLWNIQTD TLVAIFGGVE GHRDEVLSAD
     YDLLGEKIMS CGMDHSLKLW RINSLRMKTA IKESYEYNPS KTNRPFVSQK IHFPDFSTRD
     IHRNYVDCVR WLGDLILSKS CENAIVCWKP GKMEDDIDKI KPSESNVTIL GRFDYSQCDI
     WYMRFSMDFW QKMLALGNQV GKLYVWDLEA EDPHKAKCTT LTYPKCASAV RQTSFSRDSS
     ILVAVCDDAT IWRWDRLR