EEDB_XENLA
ID EEDB_XENLA Reviewed; 438 AA.
AC Q6AZS2; Q8AV63; Q8AV64; Q90YL5;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Polycomb protein eed-B;
DE Short=Xeed-B;
DE AltName: Full=psXEED;
GN Name=eed-b;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-174.
RC TISSUE=Embryo;
RG The Cancer Genome Anatomy Project (CGAP) at the National Cancer Institute;
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 3-438, PUTATIVE FUNCTION, INTERACTION WITH
RP YY1, AND DEVELOPMENTAL STAGE.
RX PubMed=11158321; DOI=10.1128/mcb.21.4.1360-1369.2001;
RA Satijn D.P.E., Hamer K.M., den Blaauwen J., Otte A.P.;
RT "The polycomb group protein EED interacts with YY1, and both proteins
RT induce neural tissue in Xenopus embryos.";
RL Mol. Cell. Biol. 21:1360-1369(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 3-438, AND DEVELOPMENTAL STAGE.
RX PubMed=12487026; DOI=10.1080/1042517021000021626;
RA Cho J.K., Chung H.M.;
RT "Characterization of Xenopus EED pseudogene, a Polycomb group gene.";
RL DNA Seq. 13:225-229(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-438.
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Polycomb group (PcG) protein. Component of the prc2/eed-ezh2
CC complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading
CC to transcriptional repression of the affected target gene (By
CC similarity). May play a role in neural induction. {ECO:0000250}.
CC -!- SUBUNIT: Component of the prc2/eed-ezh2 complex (By similarity). Can
CC interact with ezh2, hdac1 and taf9 (By similarity). Interacts with yy1.
CC {ECO:0000250, ECO:0000269|PubMed:11158321}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Maternally and zygotically expressed. Expression
CC decreases between late blastula and early gastrula.
CC {ECO:0000269|PubMed:11158321, ECO:0000269|PubMed:12487026}.
CC -!- SIMILARITY: Belongs to the WD repeat ESC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH77425.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAK59991.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAN64881.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BM179864; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AY034136; AAK59991.1; ALT_INIT; mRNA.
DR EMBL; AF460180; AAN64881.1; ALT_INIT; mRNA.
DR EMBL; AF375048; AAN75584.1; -; mRNA.
DR EMBL; BC077425; AAH77425.1; ALT_INIT; mRNA.
DR RefSeq; NP_001082354.1; NM_001088885.1.
DR AlphaFoldDB; Q6AZS2; -.
DR SMR; Q6AZS2; -.
DR DNASU; 398420; -.
DR GeneID; 398420; -.
DR KEGG; xla:398420; -.
DR CTD; 398420; -.
DR Xenbase; XB-GENE-491484; eed.S.
DR OrthoDB; 1191277at2759; -.
DR Proteomes; UP000186698; Chromosome 2S.
DR Bgee; 398420; Expressed in egg cell and 19 other tissues.
DR GO; GO:0035098; C:ESC/E(Z) complex; ISS:UniProtKB.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0016571; P:histone methylation; IEA:InterPro.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR037352; Polycomb_EED.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR10253:SF5; PTHR10253:SF5; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; WD repeat.
FT CHAIN 1..438
FT /note="Polycomb protein eed-B"
FT /id="PRO_0000343730"
FT REPEAT 88..131
FT /note="WD 1"
FT REPEAT 139..182
FT /note="WD 2"
FT REPEAT 185..225
FT /note="WD 3"
FT REPEAT 231..270
FT /note="WD 4"
FT REPEAT 301..338
FT /note="WD 5"
FT REPEAT 356..396
FT /note="WD 6"
FT REPEAT 405..438
FT /note="WD 7"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 308
FT /note="C -> G (in Ref. 3; AAN64881)"
FT /evidence="ECO:0000305"
FT CONFLICT 391
FT /note="E -> K (in Ref. 2; AAK59991)"
FT /evidence="ECO:0000305"
FT CONFLICT 398
FT /note="C -> R (in Ref. 3; AAN75584)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 438 AA; 49756 MW; CBB8FBDBCD97F0C3 CRC64;
MSEASGRAAG NEMPAKKQKL SSDENSNPEL SGDENDDSVS IESGTNTERP DTPTNAANAP
GRKGWGKGKW KSKKCKYSFK CVNSLKEDHN QPLFGVQFNW HSKEGDPLVF ATVGSNRVTL
YECHPQGDIR LLQSYVDADA DENFYTCAWT YDSNTSHPLL AVAGSRGIIR IINPITMQCI
KHYVGHGNAI NELKFHPRDP NLLLSVSKDH ALRLWNIQTD TLVAIFGGVE GHRDEVLSAD
YDLLGEKIMS CGMDHSLKLW RINSLRMKTA IKESYDYNPN KTNRPFVSQK VHFPDFSTRD
IHRNYVDCVR WLGDLILSKS CENAIVCWKP GKMEDDIEKI KASESNVTIL GRFDYSQCDI
WYMRFSMDFW QKMLALGNQV GKLYVWDLEV EDPHKAKCTT LTYPKCASAI RQTSFSRDSS
VLIAVCDDST IWRWDRLR
