ID   EED_DANRE               Reviewed;         443 AA.
AC   Q566T0; A8E5D5;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Polycomb protein eed;
GN   Name=eed; ORFNames=zgc:112509;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Polycomb group (PcG) protein. Component of the prc2/eed-ezh2
CC       complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading
CC       to transcriptional repression of the affected target gene (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the prc2/eed-ezh2 complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat ESC family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH93351.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC093351; AAH93351.1; ALT_INIT; mRNA.
DR   EMBL; BC153556; AAI53557.1; -; mRNA.
DR   AlphaFoldDB; Q566T0; -.
DR   SMR; Q566T0; -.
DR   STRING; 7955.ENSDARP00000059344; -.
DR   PaxDb; Q566T0; -.
DR   Ensembl; ENSDART00000162928; ENSDARP00000131820; ENSDARG00000099640.
DR   ZFIN; ZDB-GENE-050417-287; eed.
DR   eggNOG; KOG1034; Eukaryota.
DR   GeneTree; ENSGT00510000047334; -.
DR   HOGENOM; CLU_032683_1_0_1; -.
DR   InParanoid; Q566T0; -.
DR   OMA; WSYDSVT; -.
DR   PhylomeDB; Q566T0; -.
DR   TreeFam; TF314451; -.
DR   Reactome; R-DRE-212300; PRC2 methylates histones and DNA.
DR   Reactome; R-DRE-2559580; Oxidative Stress Induced Senescence.
DR   Reactome; R-DRE-3214841; PKMTs methylate histone lysines.
DR   Reactome; R-DRE-8943724; Regulation of PTEN gene transcription.
DR   Reactome; R-DRE-8953750; Transcriptional Regulation by E2F6.
DR   PRO; PR:Q566T0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 1.
DR   Bgee; ENSDARG00000099640; Expressed in mature ovarian follicle and 38 other tissues.
DR   GO; GO:0035098; C:ESC/E(Z) complex; ISS:UniProtKB.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0016571; P:histone methylation; IEA:InterPro.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR037352; Polycomb_EED.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR10253:SF5; PTHR10253:SF5; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; WD repeat.
FT   CHAIN           1..443
FT                   /note="Polycomb protein eed"
FT                   /id="PRO_0000343728"
FT   REPEAT          93..136
FT                   /note="WD 1"
FT   REPEAT          148..187
FT                   /note="WD 2"
FT   REPEAT          190..230
FT                   /note="WD 3"
FT   REPEAT          236..277
FT                   /note="WD 4"
FT   REPEAT          306..343
FT                   /note="WD 5"
FT   REPEAT          361..401
FT                   /note="WD 6"
FT   REPEAT          410..443
FT                   /note="WD 7"
FT   REGION          1..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..28
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..66
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   443 AA;  50616 MW;  21FD713263264665 CRC64;
     MKMRRKMSEP HGEAGNEMPN KKQKLSSDEN SNPDLSGDDN DDAVSVESGT HPERPDTPTN
     TASAPGRKSW GKGKWKSKKC KYSFKCVNSL KEDHGQPLFG VQFNWHSKEG DPLVFATVGS
     NRVTLYECHS QGEIRLLQSY VDADADENFY TCAWTFDCSS SHPLLAVAGS RGIIRIINHI
     TMQCVKHYVG HGNAINELKF HPRDPNLLLS VSKDHALRLW NIQTDTLVAI FGGVEGHRDE
     VLSADFDLLG EKIMSCGMDH SLKLWRLDSE RLQRAIRGSY EYNPSKTNRP FVSQKIHFPD
     FSTRDIHRNY VDCVRWLGDL ILSKSCENAI VCWKPGRMED DIDRIKPNES NVTILGRFDY
     SQCDIWYMRF SMDFWQKMLA LGNQVGKLYV WDLEVEDPHK AKCTTLTLPR CTSAIRQTSF
     SRDSSILIAV CDDASIWRWD RLR