ID   EED_XENTR               Reviewed;         438 AA.
AC   Q28DT7;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Polycomb protein eed;
GN   Name=eed; ORFNames=tgas047c23.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Polycomb group (PcG) protein. Component of the prc2/eed-ezh2
CC       complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading
CC       to transcriptional repression of the affected target gene (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the prc2/eed-ezh2 complex. May interact with
CC       ezh2, hdac1, taf9 and yy1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat ESC family. {ECO:0000305}.
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DR   EMBL; CR848605; CAJ83919.1; -; mRNA.
DR   RefSeq; NP_001017325.1; NM_001017325.2.
DR   AlphaFoldDB; Q28DT7; -.
DR   SMR; Q28DT7; -.
DR   STRING; 8364.ENSXETP00000022912; -.
DR   PaxDb; Q28DT7; -.
DR   Ensembl; ENSXETT00000022912; ENSXETP00000022912; ENSXETG00000010440.
DR   GeneID; 550079; -.
DR   KEGG; xtr:550079; -.
DR   CTD; 8726; -.
DR   Xenbase; XB-GENE-491480; eed.
DR   eggNOG; KOG1034; Eukaryota.
DR   HOGENOM; CLU_032683_1_0_1; -.
DR   InParanoid; Q28DT7; -.
DR   OrthoDB; 1191277at2759; -.
DR   PhylomeDB; Q28DT7; -.
DR   Reactome; R-XTR-212300; PRC2 methylates histones and DNA.
DR   Reactome; R-XTR-2559580; Oxidative Stress Induced Senescence.
DR   Reactome; R-XTR-3214841; PKMTs methylate histone lysines.
DR   Reactome; R-XTR-8943724; Regulation of PTEN gene transcription.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000010440; Expressed in 2-cell stage embryo and 12 other tissues.
DR   ExpressionAtlas; Q28DT7; differential.
DR   GO; GO:0035098; C:ESC/E(Z) complex; ISS:UniProtKB.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0016571; P:histone methylation; IEA:InterPro.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR037352; Polycomb_EED.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR10253:SF5; PTHR10253:SF5; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; WD repeat.
FT   CHAIN           1..438
FT                   /note="Polycomb protein eed"
FT                   /id="PRO_0000343731"
FT   REPEAT          88..131
FT                   /note="WD 1"
FT   REPEAT          139..182
FT                   /note="WD 2"
FT   REPEAT          185..225
FT                   /note="WD 3"
FT   REPEAT          231..270
FT                   /note="WD 4"
FT   REPEAT          301..338
FT                   /note="WD 5"
FT   REPEAT          356..396
FT                   /note="WD 6"
FT   REPEAT          405..438
FT                   /note="WD 7"
FT   REGION          1..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..54
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   438 AA;  49840 MW;  2FE245A75BFB0B36 CRC64;
     MSEASGRTAG NEMPAKKQKL SSDENSNPEL SGDENDDTVS IESGTNTERP DTPTNAANAP
     GRKGWGKGKW KSKKCKYSFK CVNSLKEDHN QPLFGVQFNW HSKEGDPLVF ATVGSNRVTL
     YECHPQGEIR LLQSYVDADA DENFYTCAWT YDSNTSHPLL AVAGSRGIIR IINPITMQCI
     KHYVGHGNAI NELKFHPRDP NLLLSVSKDH ALRLWNIQTD TLVAIFGGVE GHRDEVLSAD
     YDLLGEKIMS CGMDHSLKLW RINSLRMKTA IRESYEYNPN KTNRPFVSQK IHFPDFSTRD
     IHRNYVDCVR WLGDLILSKS CENAIVCWKP GKMEDDIDKI KASESNVTIL GRFDYSQCDI
     WYMRFSMDFW QKMLALGNQV GKLYVWDLEV EDPHKAKCTT LTYPKCASAI RQTSFSRDSS
     ILVAVCDDAT IWRWDRLR