ID   EEPD1_RAT               Reviewed;         569 AA.
AC   Q5XI74;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Endonuclease/exonuclease/phosphatase family domain-containing protein 1;
GN   Name=Eepd1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney, and Thymus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21; SER-106; SER-110 AND
RP   SER-173, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
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DR   EMBL; BC083816; AAH83816.1; -; mRNA.
DR   EMBL; BC099214; AAH99214.1; -; mRNA.
DR   RefSeq; NP_001014110.1; NM_001014088.3.
DR   RefSeq; XP_006242788.1; XM_006242726.3.
DR   AlphaFoldDB; Q5XI74; -.
DR   SMR; Q5XI74; -.
DR   STRING; 10116.ENSRNOP00000009342; -.
DR   iPTMnet; Q5XI74; -.
DR   PhosphoSitePlus; Q5XI74; -.
DR   PaxDb; Q5XI74; -.
DR   PRIDE; Q5XI74; -.
DR   Ensembl; ENSRNOT00000009342; ENSRNOP00000009342; ENSRNOG00000006931.
DR   GeneID; 315500; -.
DR   KEGG; rno:315500; -.
DR   UCSC; RGD:1307401; rat.
DR   CTD; 80820; -.
DR   RGD; 1307401; Eepd1.
DR   eggNOG; KOG1857; Eukaryota.
DR   GeneTree; ENSGT00390000009677; -.
DR   HOGENOM; CLU_033721_1_0_1; -.
DR   InParanoid; Q5XI74; -.
DR   OMA; VRVATWS; -.
DR   OrthoDB; 814192at2759; -.
DR   PhylomeDB; Q5XI74; -.
DR   TreeFam; TF328735; -.
DR   PRO; PR:Q5XI74; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000006931; Expressed in skeletal muscle tissue and 18 other tissues.
DR   Genevisible; Q5XI74; RN.
DR   GO; GO:0046658; C:anchored component of plasma membrane; ISO:RGD.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0010875; P:positive regulation of cholesterol efflux; ISO:RGD.
DR   Gene3D; 3.60.10.10; -; 1.
DR   InterPro; IPR004509; Competence_ComEA_HhH.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   SMART; SM00278; HhH1; 3.
DR   SUPFAM; SSF47781; SSF47781; 2.
DR   SUPFAM; SSF56219; SSF56219; 1.
DR   TIGRFAMs; TIGR00426; TIGR00426; 1.
PE   1: Evidence at protein level;
KW   Lipoprotein; Myristate; Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q7L9B9"
FT   CHAIN           2..569
FT                   /note="Endonuclease/exonuclease/phosphatase family domain-
FT                   containing protein 1"
FT                   /id="PRO_0000317263"
FT   DOMAIN          38..67
FT                   /note="HhH"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          200..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          548..569
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         16
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7L9B9"
FT   MOD_RES         21
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         25
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7L9B9"
FT   MOD_RES         106
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         110
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         160
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7L9B9"
FT   MOD_RES         173
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         265
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3TGW2"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   569 AA;  62868 MW;  C060E968DBFA5C37 CRC64;
     MGSTLGCHRS IPRDPSDLSH SRKFSAACNF SNILVNQERL NINTATEEEL MTLPGVTRAV
     ARSIVEYREY IGGFKKVEDL ALVSGVGATK LEQVKFEICV SSKGNSAQHS PSSLRRDLLA
     EQQPHHLATT VPLTPRVNIN TATLAQLMSV RGLSEKMAVS IVDYRREHGP FRSVEDLVRM
     DGINAAFLDR IRHQVFAERS RPPSTHTNGG LTFTAKPHPS PTSLSLQSED LDLPPGGPTQ
     IISMRPSVEA FGGMRDGRPV FRLATWNLQG CSVEKANNPG VREVVCMTLL ENSIKLLAVQ
     ELLDKEALEK FCTELNQPIL PNIRKWKGPR GCWRSIVAEK PSSQLQKGPC YSGFLWDTAA
     NVELRDIPGQ ESSPSNGHAK TVGPSPFLAR FKVGSNDLTL VNLQLTALAL PGVENSSKNH
     SDGHRLLNFA LTLQETLKGE KDVVILGDFG QGPDSSDYDI LRREKFHHLI PAHTFTNIST
     RNPQGSKSVD NIWISKSLKK VFTGHWAVVR EGLTNPWIPD NWSWGGVASE HCPVLAELYM
     EKDWSKKEVP RNGNGVTLEP SEANVKHER