EF103_ARATH
ID EF103_ARATH Reviewed; 282 AA.
AC Q8VZ91; O23591; O80387;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 2.
DT 25-MAY-2022, entry version 139.
DE RecName: Full=Ethylene-responsive transcription factor 6;
DE Short=AtERF6;
DE AltName: Full=Ethylene-responsive element-binding factor 6;
DE Short=EREBP-6;
GN Name=ERF6; Synonyms=ERF-6, ERF103; OrderedLocusNames=At4g17490;
GN ORFNames=dl4780c, FCAALL.120;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Usui A., Ohta M., Shinshi H., Ohme-Takagi M.;
RT "Arabidopsis ethylene responsive element binding factor (AtERFs).";
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9461215; DOI=10.1038/35140;
RA Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C.,
RA Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., Ridley P.,
RA Hudson S.-A., Patel K., Murphy G., Piffanelli P., Wedler H., Wedler E.,
RA Wambutt R., Weitzenegger T., Pohl T., Terryn N., Gielen J., Villarroel R.,
RA De Clercq R., van Montagu M., Lecharny A., Aubourg S., Gy I., Kreis M.,
RA Lao N., Kavanagh T., Hempel S., Kotter P., Entian K.-D., Rieger M.,
RA Schaefer M., Funk B., Mueller-Auer S., Silvey M., James R., Monfort A.,
RA Pons A., Puigdomenech P., Douka A., Voukelatou E., Milioni D.,
RA Hatzopoulos P., Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A.,
RA Moores T., Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S.,
RA Ansorge W., Cooke R., Berger C., Delseny M., Voet M., Volckaert G.,
RA Mewes H.-W., Klosterman S., Schueller C., Chalwatzis N.;
RT "Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis
RT thaliana.";
RL Nature 391:485-488(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [6]
RP FUNCTION.
RX PubMed=9756931; DOI=10.1074/jbc.273.41.26857;
RA Hao D., Ohme-Takagi M., Sarai A.;
RT "Unique mode of GCC box recognition by the DNA-binding domain of ethylene-
RT responsive element-binding factor (ERF domain) in plant.";
RL J. Biol. Chem. 273:26857-26861(1998).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16407444; DOI=10.1104/pp.105.073783;
RA Nakano T., Suzuki K., Fujimura T., Shinshi H.;
RT "Genome-wide analysis of the ERF gene family in Arabidopsis and rice.";
RL Plant Physiol. 140:411-432(2006).
CC -!- FUNCTION: Probably acts as a transcriptional activator. Binds to the
CC GCC-box pathogenesis-related promoter element. May be involved in the
CC regulation of gene expression by stress factors and by components of
CC stress signal transduction pathways (By similarity). {ECO:0000250,
CC ECO:0000269|PubMed:9756931}.
CC -!- INTERACTION:
CC Q8VZ91; Q0V7S5: At3g44610; NbExp=3; IntAct=EBI-15208888, EBI-25521307;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the AP2/ERF transcription factor family. ERF
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB10530.1; Type=Erroneous gene model prediction; Note=The predicted gene At4g17490 has been split into 2 genes: At4g17486 and At4g17490.; Evidence={ECO:0000305};
CC Sequence=CAB78752.1; Type=Erroneous gene model prediction; Note=The predicted gene At4g17490 has been split into 2 genes: At4g17486 and At4g17490.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB008316; BAB12039.1; -; mRNA.
DR EMBL; AB013301; BAA31525.1; -; mRNA.
DR EMBL; Z97343; CAB10530.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161546; CAB78752.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE83902.1; -; Genomic_DNA.
DR EMBL; AY065155; AAL38331.1; -; mRNA.
DR EMBL; AY114588; AAM47907.1; -; mRNA.
DR PIR; E71444; E71444.
DR PIR; T52189; T52189.
DR RefSeq; NP_567529.1; NM_117854.3.
DR AlphaFoldDB; Q8VZ91; -.
DR SMR; Q8VZ91; -.
DR BioGRID; 12756; 9.
DR IntAct; Q8VZ91; 7.
DR STRING; 3702.AT4G17490.1; -.
DR iPTMnet; Q8VZ91; -.
DR PaxDb; Q8VZ91; -.
DR PRIDE; Q8VZ91; -.
DR EnsemblPlants; AT4G17490.1; AT4G17490.1; AT4G17490.
DR GeneID; 827463; -.
DR Gramene; AT4G17490.1; AT4G17490.1; AT4G17490.
DR KEGG; ath:AT4G17490; -.
DR Araport; AT4G17490; -.
DR TAIR; locus:2129106; AT4G17490.
DR eggNOG; ENOG502RXE3; Eukaryota.
DR HOGENOM; CLU_058713_0_1_1; -.
DR InParanoid; Q8VZ91; -.
DR OMA; LPNKTEW; -.
DR OrthoDB; 1169658at2759; -.
DR PhylomeDB; Q8VZ91; -.
DR PRO; PR:Q8VZ91; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q8VZ91; baseline and differential.
DR Genevisible; Q8VZ91; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0051301; P:cell division; IEP:TAIR.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0009873; P:ethylene-activated signaling pathway; TAS:TAIR.
DR GO; GO:0010087; P:phloem or xylem histogenesis; IEP:TAIR.
DR GO; GO:0009644; P:response to high light intensity; IMP:TAIR.
DR GO; GO:0009624; P:response to nematode; IEP:TAIR.
DR GO; GO:0000302; P:response to reactive oxygen species; IEP:TAIR.
DR CDD; cd00018; AP2; 1.
DR Gene3D; 3.30.730.10; -; 1.
DR InterPro; IPR001471; AP2/ERF_dom.
DR InterPro; IPR036955; AP2/ERF_dom_sf.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR Pfam; PF00847; AP2; 1.
DR PRINTS; PR00367; ETHRSPELEMNT.
DR SMART; SM00380; AP2; 1.
DR SUPFAM; SSF54171; SSF54171; 1.
DR PROSITE; PS51032; AP2_ERF; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Ethylene signaling pathway; Nucleus; Plant defense;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..282
FT /note="Ethylene-responsive transcription factor 6"
FT /id="PRO_0000112566"
FT DNA_BIND 136..194
FT /note="AP2/ERF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00366"
FT REGION 77..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 41
FT /note="D -> H (in Ref. 1; BAB12039/BAA31525)"
FT /evidence="ECO:0000305"
FT CONFLICT 67
FT /note="F -> S (in Ref. 1; BAB12039/BAA31525)"
FT /evidence="ECO:0000305"
FT CONFLICT 70
FT /note="D -> E (in Ref. 1; BAB12039/BAA31525)"
FT /evidence="ECO:0000305"
FT CONFLICT 76..77
FT /note="PS -> SI (in Ref. 1; BAB12039/BAA31525)"
FT /evidence="ECO:0000305"
FT CONFLICT 126
FT /note="V -> E (in Ref. 1; BAB12039/BAA31525)"
FT /evidence="ECO:0000305"
FT CONFLICT 212
FT /note="Missing (in Ref. 1; BAB12039/BAA31525)"
FT /evidence="ECO:0000305"
FT CONFLICT 218
FT /note="G -> S (in Ref. 1; BAB12039/BAA31525)"
FT /evidence="ECO:0000305"
FT CONFLICT 224
FT /note="T -> K (in Ref. 1; BAB12039/BAA31525)"
FT /evidence="ECO:0000305"
FT CONFLICT 225
FT /note="V -> M (in Ref. 5; AAL38331/AAM47907)"
FT /evidence="ECO:0000305"
FT CONFLICT 227
FT /note="E -> K (in Ref. 1; BAB12039/BAA31525)"
FT /evidence="ECO:0000305"
FT CONFLICT 232
FT /note="T -> K (in Ref. 1; BAB12039/BAA31525)"
FT /evidence="ECO:0000305"
FT CONFLICT 237
FT /note="D -> A (in Ref. 1; BAB12039/BAA31525)"
FT /evidence="ECO:0000305"
FT CONFLICT 240
FT /note="G -> D (in Ref. 1; BAB12039/BAA31525)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 282 AA; 32108 MW; 6C785CFA721DC882 CRC64;
MATPNEVSAL FLIKKYLLDE LSPLPTTATT NRWMNDFTSF DQTGFEFSEF ETKPEIIDLV
TPKPEIFDFD VKSEIPSESN DSFTFQSNPP RVTVQSNRKP PLKIAPPNRT KWIQFATGNP
KPELPVPVVA AEEKRHYRGV RMRPWGKFAA EIRDPTRRGT RVWLGTFETA IEAARAYDKE
AFRLRGSKAI LNFPLEVDKW NPRAEDGRGL YNKRKRDGEE EEVTVVEKVL KTEESYDVSG
GENVESGLTA IDDWDLTEFL SMPLLSPLSP HPPFGYPQLT VV
