ID   ADRL_CAEBR              Reviewed;         423 AA.
AC   A8WZU4;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Progestin and adipoQ receptor-like protein 1;
GN   Name=paqr-1 {ECO:0000312|WormBase:CBG05420}; ORFNames=CBG05420;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1] {ECO:0000312|EMBL:CAP25904.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Probable receptor, which may be involved in metabolic
CC       pathways that regulate lipid metabolism such as fatty acid oxidation.
CC       {ECO:0000250|UniProtKB:Q94177}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000255}.
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DR   EMBL; HE601369; CAP25904.2; -; Genomic_DNA.
DR   AlphaFoldDB; A8WZU4; -.
DR   SMR; A8WZU4; -.
DR   STRING; 6238.CBG05420; -.
DR   WormBase; CBG05420; CBP01389; WBGene00027874; Cbr-paqr-1.
DR   eggNOG; KOG0748; Eukaryota.
DR   HOGENOM; CLU_023075_1_0_1; -.
DR   InParanoid; A8WZU4; -.
DR   OMA; EIMTDGK; -.
DR   OrthoDB; 1524940at2759; -.
DR   Proteomes; UP000008549; Chromosome IV.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0033211; P:adiponectin-activated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR004254; AdipoR/HlyIII-related.
DR   InterPro; IPR001610; PAC.
DR   PANTHER; PTHR20855; PTHR20855; 2.
DR   Pfam; PF03006; HlyIII; 2.
DR   SMART; SM00086; PAC; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism; Lipid metabolism; Membrane; Receptor;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..423
FT                   /note="Progestin and adipoQ receptor-like protein 1"
FT                   /id="PRO_0000398804"
FT   TOPO_DOM        1..201
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        223..234
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..252
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        253..288
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        310..320
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        321..341
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        342..351
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        352..372
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        373..392
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..413
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        414..423
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          54..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        111..140
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   423 AA;  48054 MW;  0A08E4220E3B1072 CRC64;
     MDPDEVNQAL GHYLNDSESG ELVVEDSTTV QVTNPEARKT GDKIEVYYSR KTTVVSPTNS
     DDEEGEFCSD SELLPAQGGH RSRATSFAGR VRAGSDDEMN PKHTVLRYRR KKGGQWREVN
     AQGTPDKRKD DEDELEVDVK EDRSEQTGIV TKTYEARWKV LKYEHLPEWL QDNEFLRHGH
     RPPLPSFAEC FKSIWSLHTE TGNIWTHLIG CVAFFLLACW FLTRPDNHIQ FQEKVVFSFF
     FAGAVSVSDS RSPSTPSRVI RSTSSRYSAN STIWESRCSL SARLFQPKIT YIAMVCVLGI
     GAIVVSLWDK FSESKYRPVR AAVFVGMGCS GVIPTIHYII TDGVHSLFAD NSFHWLLLMA
     FLYLLGAALY ATRTPERFFP GKCDIWFQSH QLFHTCVVIA AFVHYYGISE MAFARLNEQC
     PVR