ID   ADRL_CAEEL              Reviewed;         434 AA.
AC   Q94177;
DT   14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 2.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Progestin and adipoQ receptor-like protein 1;
GN   Name=paqr-1; ORFNames=C43G2.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Probable receptor, which may be involved in metabolic
CC       pathways that regulate lipid metabolism such as fatty acid oxidation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
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DR   EMBL; FO080265; CCD62451.1; -; Genomic_DNA.
DR   PIR; D88710; D88710.
DR   RefSeq; NP_500998.1; NM_068597.5.
DR   AlphaFoldDB; Q94177; -.
DR   SMR; Q94177; -.
DR   BioGRID; 42537; 1.
DR   STRING; 6239.C43G2.1.1; -.
DR   iPTMnet; Q94177; -.
DR   EPD; Q94177; -.
DR   PaxDb; Q94177; -.
DR   PeptideAtlas; Q94177; -.
DR   EnsemblMetazoa; C43G2.1a.1; C43G2.1a.1; WBGene00016610.
DR   UCSC; C43G2.1.1; c. elegans.
DR   WormBase; C43G2.1a; CE27848; WBGene00016610; paqr-1.
DR   eggNOG; KOG0748; Eukaryota.
DR   InParanoid; Q94177; -.
DR   OMA; DYCGIAM; -.
DR   OrthoDB; 1524940at2759; -.
DR   PhylomeDB; Q94177; -.
DR   PRO; PR:Q94177; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00016610; Expressed in germ line (C elegans) and 4 other tissues.
DR   ExpressionAtlas; Q94177; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0033211; P:adiponectin-activated signaling pathway; IBA:GO_Central.
DR   GO; GO:0019395; P:fatty acid oxidation; ISS:UniProtKB.
DR   GO; GO:0009755; P:hormone-mediated signaling pathway; ISS:UniProtKB.
DR   GO; GO:0046321; P:positive regulation of fatty acid oxidation; IGI:WormBase.
DR   InterPro; IPR004254; AdipoR/HlyIII-related.
DR   InterPro; IPR001610; PAC.
DR   PANTHER; PTHR20855; PTHR20855; 1.
DR   Pfam; PF03006; HlyIII; 1.
DR   SMART; SM00086; PAC; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism; Lipid metabolism; Membrane; Receptor;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..434
FT                   /note="Progestin and adipoQ receptor-like protein 1"
FT                   /id="PRO_0000218831"
FT   TOPO_DOM        1..201
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        223..234
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        256..273
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..294
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        295..299
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..320
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        321..331
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        332..352
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        353..362
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        363..383
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        384..403
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        404..424
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        425..434
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          74..103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          118..137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   434 AA;  49753 MW;  BD4F2C0FC9E77AED CRC64;
     MNPDEVNRAL GHYLNDADSG ELVVEDSTTV QVKNPEARKT GDKIEVFYSR KTTVVSPTNS
     DDEDADFCSD SELLPQQEGH RSRATSFAGR IRAGSDDEAM PKHTILRYRR KKGGQWREIN
     LQGTPDKRKD DEDELEVDVK EDRSEQTGIV TKTYEARWKV LKYEHLPEWL QDNEFLRHGH
     RPPLPSFSEC FKSIWSLHTE TGNIWTHLIG CVAFFFLACW FLTRPDNHIQ FQEKVVFSFF
     FAGAVLCLGL SFAFHTLSCH SVNVVKIFCK LDYMGISLLI IGSFIPWIYY GFYCRREPKI
     TYIAMVSVLG IGAIVVSLWD KFSESRFRPI RAAVFVGMGC SGVIPTIHYI ITDGVHSLFA
     DNSFHWLLLM AFLYLLGAGL YATRTPERFF PGKCDIWFQS HQLFHTCVVI AAFVHYYGIS
     EMAFARLNEQ CPVR