ADRL_DROME
ID ADRL_DROME Reviewed; 444 AA.
AC Q9VCY8; Q9VCY9;
DT 14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Adiponectin receptor protein;
GN Name=AdipoR; ORFNames=CG5315;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-283 (ISOFORM 2).
RC STRAIN=Berkeley; TISSUE=Embryo, and Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=23874700; DOI=10.1371/journal.pone.0068641;
RA Kwak S.J., Hong S.H., Bajracharya R., Yang S.Y., Lee K.S., Yu K.;
RT "Drosophila adiponectin receptor in insulin producing cells regulates
RT glucose and lipid metabolism by controlling insulin secretion.";
RL PLoS ONE 8:E68641-E68641(2013).
CC -!- FUNCTION: Adiponectin receptor. In insulin-producing cells, regulates
CC insulin secretion and controls glucose and lipid metabolism.
CC {ECO:0000269|PubMed:23874700}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9VCY8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9VCY8-2; Sequence=VSP_008889, VSP_008890;
CC -!- TISSUE SPECIFICITY: In larval and adult brain, expressed in insulin-
CC producing cells and in neurons of the subesophageal region. Also
CC expressed in lateral neurons of the adult brain (at protein level). In
CC third instar larvae, expressed in central nervous system (CNS),
CC imaginal disk, salivary gland, fat body, gut and malphigian tubules.
CC {ECO:0000269|PubMed:23874700}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout development and in adult.
CC {ECO:0000269|PubMed:23874700}.
CC -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
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DR EMBL; AE014297; AAF56016.2; -; Genomic_DNA.
DR EMBL; AE014297; AAF56017.3; -; Genomic_DNA.
DR EMBL; BI585801; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BT001487; AAN71242.1; -; mRNA.
DR RefSeq; NP_001247239.1; NM_001260310.2. [Q9VCY8-1]
DR RefSeq; NP_001262844.1; NM_001275915.1. [Q9VCY8-1]
DR RefSeq; NP_651061.1; NM_142804.3. [Q9VCY8-1]
DR RefSeq; NP_732758.1; NM_170019.2. [Q9VCY8-1]
DR RefSeq; NP_732759.2; NM_170020.2. [Q9VCY8-2]
DR AlphaFoldDB; Q9VCY8; -.
DR SMR; Q9VCY8; -.
DR BioGRID; 67611; 9.
DR IntAct; Q9VCY8; 5.
DR STRING; 7227.FBpp0083675; -.
DR PaxDb; Q9VCY8; -.
DR PRIDE; Q9VCY8; -.
DR DNASU; 42656; -.
DR EnsemblMetazoa; FBtr0084282; FBpp0083675; FBgn0038984. [Q9VCY8-1]
DR EnsemblMetazoa; FBtr0084283; FBpp0083676; FBgn0038984. [Q9VCY8-1]
DR EnsemblMetazoa; FBtr0084284; FBpp0083677; FBgn0038984. [Q9VCY8-2]
DR EnsemblMetazoa; FBtr0308848; FBpp0301003; FBgn0038984. [Q9VCY8-1]
DR EnsemblMetazoa; FBtr0334561; FBpp0306628; FBgn0038984. [Q9VCY8-1]
DR GeneID; 42656; -.
DR KEGG; dme:Dmel_CG5315; -.
DR UCSC; CG5315-RA; d. melanogaster. [Q9VCY8-1]
DR CTD; 42656; -.
DR FlyBase; FBgn0038984; AdipoR.
DR VEuPathDB; VectorBase:FBgn0038984; -.
DR eggNOG; KOG0748; Eukaryota.
DR GeneTree; ENSGT00940000170813; -.
DR HOGENOM; CLU_023075_1_1_1; -.
DR InParanoid; Q9VCY8; -.
DR OMA; DYCGIAM; -.
DR PhylomeDB; Q9VCY8; -.
DR BioGRID-ORCS; 42656; 0 hits in 3 CRISPR screens.
DR ChiTaRS; AdipoR; fly.
DR GenomeRNAi; 42656; -.
DR PRO; PR:Q9VCY8; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0038984; Expressed in mouthpart and 38 other tissues.
DR ExpressionAtlas; Q9VCY8; baseline and differential.
DR Genevisible; Q9VCY8; DM.
DR GO; GO:0016021; C:integral component of membrane; ISM:FlyBase.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016500; F:protein-hormone receptor activity; ISS:FlyBase.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0033211; P:adiponectin-activated signaling pathway; IBA:GO_Central.
DR GO; GO:0019395; P:fatty acid oxidation; ISS:UniProtKB.
DR GO; GO:0036099; P:female germ-line stem cell population maintenance; IMP:FlyBase.
DR GO; GO:0042593; P:glucose homeostasis; IMP:FlyBase.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IMP:FlyBase.
DR GO; GO:0032024; P:positive regulation of insulin secretion; IMP:FlyBase.
DR GO; GO:0070328; P:triglyceride homeostasis; IMP:FlyBase.
DR InterPro; IPR004254; AdipoR/HlyIII-related.
DR PANTHER; PTHR20855; PTHR20855; 1.
DR Pfam; PF03006; HlyIII; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Fatty acid metabolism;
KW Lipid metabolism; Membrane; Metal-binding; Receptor; Reference proteome;
KW Transmembrane; Transmembrane helix; Zinc.
FT CHAIN 1..444
FT /note="Adiponectin receptor protein"
FT /id="PRO_0000218832"
FT TOPO_DOM 1..204
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..237
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..276
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..302
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 324..334
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 335..355
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 356..365
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 387..405
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 406..426
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 427..444
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 258
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q86V24"
FT BINDING 404
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q86V24"
FT BINDING 408
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q86V24"
FT VAR_SEQ 1..82
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12537569"
FT /id="VSP_008889"
FT VAR_SEQ 83..122
FT /note="DSLSPNDLDILEYDDELVEEDDAGCPLPSTPEDTQLIEAE -> MQTQPEVI
FT VRVNPDLEPDLSQETYRTQNPDTVKEQAENAV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12537569"
FT /id="VSP_008890"
SQ SEQUENCE 444 AA; 49757 MW; AAFFE1C9DA935A02 CRC64;
MDSATNLLEQ QGSAADVSGG SHPAEVEVTT QARATFGMDA EGHATGEAVT TTTATLRREG
SDEDIFEQVQ MILRKRRGWG PEDSLSPNDL DILEYDDELV EEDDAGCPLP STPEDTQLIE
AEMTEVLKAG VLSDEIDLGA LAHNAAEQAE EFVRKVWEAS WKVCHYKNLP KWLQDNDFLH
RGHRPPLPSF RACFKSIFRV HTETGNIWTH LLGCIAFIGV ALYFISRPSV EIQTQEKIVF
GAFFIGAIVC LGFSFAFHTL SCHSVEMGRL FSKLDYCGIA LLIMGSFVPW LYYGFYCHYQ
PKVIYLSVVS ILGILSIVVS LWDKFSEPAL RPLRAGVFMS FGLSGVIPAI HYSIMEGWFS
QMSRASLGWL ILMGLLYILG ALLYALRVPE RWFPGKFDIW GQSHQIFHIL VIAAAFVHYH
GISEMAMYRV MYSECTVPIE PITF
