ADRM1_CAEEL
ID ADRM1_CAEEL Reviewed; 374 AA.
AC Q09289;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 20-JUN-2002, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Proteasomal ubiquitin receptor ADRM1 homolog {ECO:0000305};
DE AltName: Full=Proteasome non-ATPase regulatory particle-like protein 13 {ECO:0000312|WormBase:C56G2.7a};
GN Name=rpn-13 {ECO:0000312|WormBase:C56G2.7a};
GN ORFNames=C56G2.7 {ECO:0000312|WormBase:C56G2.7a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP INTERACTION WITH UBH-4.
RX PubMed=23770237; DOI=10.1016/j.celrep.2013.05.012;
RA Matilainen O., Arpalahti L., Rantanen V., Hautaniemi S., Holmberg C.I.;
RT "Insulin/IGF-1 signaling regulates proteasome activity through the
RT deubiquitinating enzyme UBH-4.";
RL Cell Rep. 3:1980-1995(2013).
CC -!- FUNCTION: May function as a proteasomal ubiquitin receptor. May promote
CC the deubiquitinating activity associated with the 26S proteasome.
CC {ECO:0000250|UniProtKB:Q16186}.
CC -!- SUBUNIT: Component of the 19S proteasome regulatory particle complex
CC (By similarity). The 26S proteasome consists of a 20S core particle
CC (CP) and two 19S regulatory subunits (RP) (By similarity). Interacts
CC with deubiquitinase ubh-4 (PubMed:23770237).
CC {ECO:0000250|UniProtKB:Q16186, ECO:0000269|PubMed:23770237}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q16186}. Nucleus
CC {ECO:0000250|UniProtKB:Q16186}.
CC -!- DOMAIN: The Pru (pleckstrin-like receptor for ubiquitin) domain
CC mediates interactions with rpn-2 and ubiquitin. Preferential binding to
CC the proximal subunit of K48-linked diubiquitin allows ubh-4 access to
CC the distal subunit. {ECO:0000250|UniProtKB:Q16186}.
CC -!- SIMILARITY: Belongs to the ADRM1 family. {ECO:0000305}.
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DR EMBL; BX284603; CCD66338.1; -; Genomic_DNA.
DR RefSeq; NP_498387.2; NM_065986.6.
DR AlphaFoldDB; Q09289; -.
DR SMR; Q09289; -.
DR BioGRID; 533206; 41.
DR IntAct; Q09289; 5.
DR STRING; 6239.C56G2.7; -.
DR iPTMnet; Q09289; -.
DR EPD; Q09289; -.
DR PaxDb; Q09289; -.
DR PeptideAtlas; Q09289; -.
DR EnsemblMetazoa; C56G2.7a.1; C56G2.7a.1; WBGene00016981.
DR GeneID; 3565888; -.
DR KEGG; cel:CELE_C56G2.7; -.
DR UCSC; C56G2.7; c. elegans.
DR CTD; 3565888; -.
DR WormBase; C56G2.7a; CE30640; WBGene00016981; rpn-13.
DR eggNOG; KOG3037; Eukaryota.
DR GeneTree; ENSGT00390000013839; -.
DR HOGENOM; CLU_041798_0_0_1; -.
DR InParanoid; Q09289; -.
DR OMA; SNQRHFF; -.
DR PhylomeDB; Q09289; -.
DR Reactome; R-CEL-5689603; UCH proteinases.
DR Reactome; R-CEL-5689880; Ub-specific processing proteases.
DR PRO; PR:Q09289; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00016981; Expressed in adult organism and 4 other tissues.
DR ExpressionAtlas; Q09289; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000502; C:proteasome complex; ISS:UniProtKB.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IBA:GO_Central.
DR GO; GO:0061133; F:endopeptidase activator activity; ISS:UniProtKB.
DR GO; GO:0070628; F:proteasome binding; IBA:GO_Central.
DR GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR GO; GO:1990381; F:ubiquitin-specific protease binding; IPI:UniProtKB.
DR GO; GO:0043248; P:proteasome assembly; ISS:UniProtKB.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 1.10.2020.20; -; 1.
DR Gene3D; 2.30.29.70; -; 1.
DR InterPro; IPR044867; DEUBAD_dom.
DR InterPro; IPR006773; Rpn13/ADRM1.
DR InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR InterPro; IPR032368; RPN13_DEUBAD.
DR InterPro; IPR038108; RPN13_DEUBAD_sf.
DR PANTHER; PTHR12225; PTHR12225; 1.
DR Pfam; PF04683; Proteasom_Rpn13; 1.
DR Pfam; PF16550; RPN13_C; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS51917; PRU; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Proteasome; Reference proteome.
FT CHAIN 1..374
FT /note="Proteasomal ubiquitin receptor ADRM1 homolog"
FT /id="PRO_0000065257"
FT DOMAIN 13..131
FT /note="Pru"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01265"
FT DOMAIN 239..346
FT /note="DEUBAD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01264"
FT REGION 126..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..374
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 374 AA; 39773 MW; FD37CFC6EB991044 CRC64;
MAAMFSNTRS VASSSGHIVE FKAGRSRLEA GSGDTMRKVV AEPKKGLVFI KQSNDMLIHF
CWKDRETGAV VDDLIIFPDD AEFKAVPGCP DGKVYMLKFK SGDMKLFWIQ DSTPDVDKDL
VKKVTDALNK PPTSRPAASR SAGSNANTDR QSAGGSLISS SDMNAPLGGI DQGQLMSLIQ
SLQGGNSDTL PISSVPRGED ASSEADCEPS TNAAEEGSSN PLSLNNPAIQ QIFNNLGRSQ
KKEVAVSLAT ALSNETVAEV ARNHAEELAP HLPTSDDPAR ELSETVRTPQ FRQAADTLGH
ALQTGQLGPV VAQFGMDEAT VGSANQGDIR GFAANLTKAE GGEDAAKTQN SDDDATREPE
PKRNRPDNED MDVD
