ADRM1_DICDI
ID ADRM1_DICDI Reviewed; 287 AA.
AC Q556N5; Q8MYI8;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Proteasomal ubiquitin receptor ADRM1 homolog;
GN Name=adrm1-1; ORFNames=DDB_G0272624;
GN and
GN Name=adrm1-2; ORFNames=DDB_G0274093;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP INTERACTION WITH PHG2, AND FUNCTION.
RX PubMed=16987957; DOI=10.1091/mbc.e06-07-0619;
RA Cherix N., Froquet R., Charette S.J., Blanc C., Letourneur F., Cosson P.;
RT "A Phg2-Adrm1 pathway participates in the nutrient-controlled developmental
RT response in Dictyostelium.";
RL Mol. Biol. Cell 17:4982-4987(2006).
CC -!- FUNCTION: Functions as a proteasomal ubiquitin receptor. Recruits the
CC deubiquitinating enzyme uchl5 at the 26S proteasome and promotes its
CC activity (By similarity). Plays a role in the transition from growth to
CC differentiation (PubMed:16987957). {ECO:0000250|UniProtKB:Q16186,
CC ECO:0000269|PubMed:16987957}.
CC -!- SUBUNIT: Interacts with the 26S proteasome (By similarity). Interacts
CC with phg2 (PubMed:16987957). {ECO:0000250|UniProtKB:Q16186,
CC ECO:0000269|PubMed:16987957}.
CC -!- INTERACTION:
CC Q556N5; Q54QQ1: phg2; NbExp=3; IntAct=EBI-1807967, EBI-1807983;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q16186}. Nucleus
CC {ECO:0000250|UniProtKB:Q16186}.
CC -!- SIMILARITY: Belongs to the ADRM1 family. {ECO:0000305}.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000011; EAL70480.1; -; Genomic_DNA.
DR EMBL; AAFI02000009; EAL70949.1; -; Genomic_DNA.
DR RefSeq; XP_644405.1; XM_639313.1.
DR RefSeq; XP_645008.1; XM_639916.1.
DR AlphaFoldDB; Q556N5; -.
DR SMR; Q556N5; -.
DR IntAct; Q556N5; 1.
DR STRING; 44689.DDB0233908; -.
DR PaxDb; Q556N5; -.
DR EnsemblProtists; EAL70480; EAL70480; DDB_G0274093.
DR EnsemblProtists; EAL70949; EAL70949; DDB_G0272624.
DR GeneID; 8618685; -.
DR GeneID; 8619291; -.
DR KEGG; ddi:DDB_G0272624; -.
DR KEGG; ddi:DDB_G0274093; -.
DR dictyBase; DDB_G0272624; adrm1-1.
DR dictyBase; DDB_G0274093; adrm1-2.
DR eggNOG; KOG3037; Eukaryota.
DR HOGENOM; CLU_041798_0_0_1; -.
DR InParanoid; Q556N5; -.
DR OMA; SNQRHFF; -.
DR PhylomeDB; Q556N5; -.
DR Reactome; R-DDI-5689603; UCH proteinases.
DR Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR PRO; PR:Q556N5; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000502; C:proteasome complex; ISS:UniProtKB.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IBA:GO_Central.
DR GO; GO:0061133; F:endopeptidase activator activity; ISS:UniProtKB.
DR GO; GO:0070628; F:proteasome binding; IBA:GO_Central.
DR GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR GO; GO:0019954; P:asexual reproduction; IMP:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IMP:UniProtKB.
DR GO; GO:0031670; P:cellular response to nutrient; IMP:dictyBase.
DR GO; GO:0043248; P:proteasome assembly; ISS:UniProtKB.
DR GO; GO:0031156; P:regulation of sorocarp development; IMP:dictyBase.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; ISS:UniProtKB.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 1.10.2020.20; -; 1.
DR Gene3D; 2.30.29.70; -; 1.
DR InterPro; IPR044867; DEUBAD_dom.
DR InterPro; IPR006773; Rpn13/ADRM1.
DR InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR InterPro; IPR032368; RPN13_DEUBAD.
DR InterPro; IPR038108; RPN13_DEUBAD_sf.
DR PANTHER; PTHR12225; PTHR12225; 1.
DR Pfam; PF04683; Proteasom_Rpn13; 1.
DR Pfam; PF16550; RPN13_C; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS51917; PRU; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Phosphoprotein; Proteasome; Reference proteome.
FT CHAIN 1..287
FT /note="Proteasomal ubiquitin receptor ADRM1 homolog"
FT /id="PRO_0000327704"
FT DOMAIN 2..118
FT /note="Pru"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01265"
FT DOMAIN 177..286
FT /note="DEUBAD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01264"
FT REGION 130..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 287 AA; 32349 MW; 0EA944D0229C63EE CRC64;
MNRPPQDVEF KAGKAKLTGT TVTSDSRKGY LKFGVTPEGL TCVQWRPRDS SAYEDEFYFA
PGESKFIKVP ACKTGRMYYL NFSGSDQKEF YWLQEANVEG DAKIEKALKV IESYIPDDDD
DEEMVVDTPP PTTTIKQEPP KNPTINEVSL SQPKPTTTPP PSATNLDFIK DLFSNLPTQP
KQPQITLGKI LTAENLIPFL RENPEIKKDL IQYLPEEYQK DENMINEVLH SAQFLQSIET
LDYAIHEGHG PEIVSLLGYE PSIASQRGVE GFLTNIQEGT NKKKNNK
