ADSL1_ARATH
ID ADSL1_ARATH Reviewed; 299 AA.
AC Q9LND9; Q8LDI2;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Delta-9 desaturase-like 1 protein;
DE EC=1.14.19.-;
GN OrderedLocusNames=At1g06090; ORFNames=T21E18.14, T21E18_11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
CC -!- PATHWAY: Lipid metabolism; polyunsaturated fatty acid biosynthesis.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- DOMAIN: The histidine box domains may contain the active site and/or be
CC involved in metal ion binding. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the fatty acid desaturase type 1 family.
CC {ECO:0000305}.
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DR EMBL; AC024174; AAF80132.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE27938.1; -; Genomic_DNA.
DR EMBL; AY085993; AAM63203.1; -; mRNA.
DR PIR; B86196; B86196.
DR RefSeq; NP_172099.1; NM_100490.4.
DR AlphaFoldDB; Q9LND9; -.
DR SMR; Q9LND9; -.
DR STRING; 3702.AT1G06090.1; -.
DR PaxDb; Q9LND9; -.
DR PRIDE; Q9LND9; -.
DR ProteomicsDB; 244715; -.
DR EnsemblPlants; AT1G06090.1; AT1G06090.1; AT1G06090.
DR GeneID; 837118; -.
DR Gramene; AT1G06090.1; AT1G06090.1; AT1G06090.
DR KEGG; ath:AT1G06090; -.
DR Araport; AT1G06090; -.
DR TAIR; locus:2198801; AT1G06090.
DR eggNOG; KOG1600; Eukaryota.
DR HOGENOM; CLU_027359_1_0_1; -.
DR InParanoid; Q9LND9; -.
DR OMA; DPHSPHH; -.
DR OrthoDB; 971318at2759; -.
DR PhylomeDB; Q9LND9; -.
DR BioCyc; ARA:AT1G06090-MON; -.
DR UniPathway; UPA00658; -.
DR PRO; PR:Q9LND9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9LND9; baseline and differential.
DR Genevisible; Q9LND9; AT.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009979; F:16:0 monogalactosyldiacylglycerol desaturase activity; IBA:GO_Central.
DR GO; GO:0016717; F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water; IEA:InterPro.
DR GO; GO:0006636; P:unsaturated fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd03505; Delta9-FADS-like; 1.
DR InterPro; IPR015876; Acyl-CoA_DS.
DR InterPro; IPR005804; FA_desaturase_dom.
DR PANTHER; PTHR11351; PTHR11351; 1.
DR Pfam; PF00487; FA_desaturase; 1.
DR PRINTS; PR00075; FACDDSATRASE.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism;
KW Iron; Lipid biosynthesis; Lipid metabolism; Membrane; Oxidoreductase;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..299
FT /note="Delta-9 desaturase-like 1 protein"
FT /id="PRO_0000185427"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOTIF 77..82
FT /note="Histidine box-1"
FT MOTIF 114..118
FT /note="Histidine box-2"
FT MOTIF 246..250
FT /note="Histidine box-3"
FT CONFLICT 23
FT /note="F -> L (in Ref. 3; AAM63203)"
FT /evidence="ECO:0000305"
FT CONFLICT 33
FT /note="I -> L (in Ref. 3; AAM63203)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 299 AA; 34770 MW; 4640982A38CA9E46 CRC64;
MGDTTKDDGS SQSKAVRGEK RAFFFRKWTR IDIARASAVG AVHLLCLLAP FNYKWEALRF
GVILAIVTSL SITFSYHRNL THKSFKLPKW LEYPFAYSAL FALQGHPIDW VSTHRFHHQF
TDSDRDPHSP IEGFWFSHVF WIFDTSYIRE KCGGRDNVMD LKQQWFYRFL RNTIGLHILT
FWTLVYLWGG LPYLTCGVGV GGTIGYNGTW LINSACHIWG SRAWNTKDTS RNIWWLGPFT
MGESWHNNHH AFEASARHGL EWYQVDLTWY LICFFQALGL ATDVKLPTDA QKRKLAFAR
